Microbiology and Immunology Training for HIV and HIV-Related Research in Uganda (MITHU)

摘要（450字; 29行） 这种竞争性的更新是建立在前4年“微生物学和免疫学培训”的成功基础上的 乌干达艾滋病毒和艾滋病毒相关研究”（MITHU）培训计划。MITHU解决能力建设问题 在乌干达开展关于艾滋病毒和艾滋病毒相关并发症的基础/转化生物医学研究。持续存在 艾滋病毒流行，加上不断演变的SARS-CoV-2（COVID-19）大流行和其他新出现的 感染，强调了免疫学和分子生物学实验室研究能力的重要性， 微生物学用于跟踪、预防、诊断和治疗。这种能力需要生物医学教师在 Makerere大学（MU）和乌干达的其他机构，以培训下一代生物医学 技术人员、研究人员和教员。对于这种竞争性的更新，MITHU提出了5个新目标。目标1.到 继续MITHU在支持MU生物医学硕士培训方面的成功。我们建议继续MSc培训 作为下一个融资周期的主要目标。最好的理学硕士学生将继续进行生物医学博士培训。目的 2.通过启动生物医学科学的三明治博士课程来扩大MU的生物医学博士培训， CWRU。我们提出了三明治博士学位，优秀的硕士学生将由MU的教师共同指导 和CWRU，花他们的第一年在CWRU在免疫学或分子微生物学选定的课程工作， 做实验室轮换，并选择CWRU和MU导师为他们的论文项目。论文研究将开始在 CWRU将在MU完成。这个三明治博士课程是可能的，因为现在有9 MU生物医学科学学院的生物医学研究系。9人中有6人在CWRU接受了培训，2人接受了培训。 在MU由乌干达CWRU研究合作和1在华盛顿大学。目标3.继续指导 初级生物医学科学教师，并为返回的博士生提供再就业支持，因为他们建立 他们是乌干达的生物医学教师和研究人员。MITHU将继续协调指导 该计划为初级和高级研究科学家与健康科学学院的教学计划。 MITHU还将继续为返回乌干达的博士生提供再就业支持。改进的互联网 上网极大地改善了远程学习和洲际互动，允许远程指导， 实验室会议和期刊俱乐部目标4。继续赞助每年举办的短期强化课程“东道主- HIV、TB及其并发症中的病原体相互作用。这个受欢迎的课程是由MU生物医学参加 硕士、硕士和博士生。本课程是讲座，期刊俱乐部和研讨会的混合体，其中MU- 和CWRU赞助的科学家提出了最新的生物医学成果和方法有关的艾滋病毒及其 并发症目标5。为了继续为MITHU利用乌干达-CWRU研究合作的 艾滋病毒和结核病研究的专门知识和基础设施，用于艾滋病毒及其 并发症

Abstract (450 words; 29 lines) This competing renewal builds on the success of the first 4 yrs. of the "Microbiology and Immunology Training for HIV and HIV-Related Research in Uganda” (MITHU) training program. MITHU addresses capacity building in basic/translational biomedical research on HIV and HIV-related complications in Uganda. Persistence of the HIV epidemic, compounded by the evolving SARS-CoV-2 (COVID-19) pandemic and other emerging infections, emphasizes the importance of lab-based research capacity in immunology and molecular microbiology for tracking, prevention, diagnosis and treatment. This capacity requires biomedical faculty at Makerere University (MU) and other institutions in Uganda to train the next generation of biomedical technicians, researchers and faculty. For this competing renewal, MITHU proposes the 5 New Aims. Aim 1. To continue MITHU's success in supporting biomedical MSc training at MU. We propose to continue MSc training as a primary Aim for this next funding cycle. The best MSc students will go on to biomedical PhD training. Aim 2. To expand Biomedical PhD Training at MU by starting a Sandwich PhD program in biomedical sciences with CWRU. We propose a Sandwich PhD where outstanding MSc students will be co-mentored by faculty from MU and CWRU, spend their first yr at CWRU for selected course work in immunology or molecular microbiology, to do lab rotations, and to select CWRU and MU mentors for their thesis project. Thesis research will begin at CWRU and will be completed at MU. This Sandwich PhD program is possible because there are now 9 biomedical research faculty in MU's School of Biomedical Sciences. Six of 9 were trained at CWRU, 2 trained at MU by the Uganda-CWRU Research Collaboration and 1 at Univ. of Wash. Aim 3. To continue mentoring of junior biomedical science faculty and providing re-entry support for returning PhD trainees as they establish themselves as biomedical faculty and researchers in Uganda. MITHU will continue to coordinate a mentoring program for junior and senior research scientists with the College of Health Sciences' NURTURE program. MITHU will also continue to provide re-entry support for PhD trainees returning to Uganda. Improved internet access has greatly improved distance-learning and intercontinental interactions, allowing for remote mentoring, lab meetings and journal clubs. Aim 4. To continue to sponsor the yearly short intensive course “Host- Pathogen interactions in HIV, TB and their complications. This popular course is attended by MU biomedical MSc, MMed and PhD students. This course is a mixture of lectures, journal clubs and workshops in which MU- and CWRU-sponsored scientists present the latest biomedical results and methods related to HIV and its complications. Aim 5. To continue to leverage for MITHU the Uganda-CWRU Research Collaboration's expertise and infrastructure for HIV and TB research for training in the biomedical sciences of HIV and its complications.