A Mulit-Centered Prospective Study of Quality of Life in Adult Scoliosis

成人脊柱侧凸生活质量的多中心前瞻性研究

• 批准号: 8727256
• 负责人: Keith Happ Bridwell
• 金额: $ 44.3万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2017-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8727256
• 关键词: Adult; Adverse event; Affect; Aftercare; Age; Age Factors; American; Analgesics; Appearance; Back Pain; Body mass index; Bone Density; Caring; Clinical; Cohort Studies; Comorbidity; Complex; Data; Decision Making; Deformity; Development; Disease; Education; Effectiveness; Elderly; Evidence based treatment; Gender; Goals; Guidelines; Health Care Costs; Healthcare; Hospital Costs; Hospitalization; Inferior; Injection of therapeutic agent; Institution; Intervention; Light; Literature; Lumbar Curve; Measurement; Measures; Mental Health; Methods; Modeling; North America; Older Population; Operative Surgical Procedures; Orthopedic Surgery procedures; Orthopedics; Outcome; Outcome Study; Outcomes Research; Pain; Pain in lower limb; Pathology; Patient Care; Patient Outcomes Assessments; Patients; Peer Review; Physical therapy; Population; Population Study; Practice Management; Prevalence; Prospective Studies; Quality of life; Randomized; Randomized Controlled Trials; Research; Research Infrastructure; Research Personnel; Research Support; Resources; Review Literature; Risk; SF-12; Severities; Societies; Socioeconomic Status; Speed; Spinal; Spinal Curvatures; Target Populations; Time; Treadmill Tests; Treatment outcome; Validity of Results; Vertebral column; Walking; aged; aging population; arm; arthropathies; burden of illness; clinical practice; cohort; comparative treatment; cost; disability; evidence base; experience; follow-up; health related quality of life; improved; indexing; innovation; instrument; member; patient oriented research; post intervention; predictive modeling; preference; prospective; randomized trial; scoliosis; tool

ABSTRACT The goal of this patient-oriented study is to obtain health-related quality of life (HRQOL) outcomes data on patients who present with adult symptomatic lumbar scoliosis (ASLS) pre- and post-treatment in order to facilitate the development of evidence-based treatment guidelines, improve patient care and optimize healthcare resource utilization. We are defining ASLS as Oswestry Disability Index (ODI) e20, Scoliosis Research Society (SRS) domain scores d4.0 and a Cobb measurement of e30¿ at baseline. This study will help us determine how much the current treatment, either nonoperative or operative, improves the lives of people with this pathology. Significance: The impetus for this critical effort is the significant burden of disease posed by adult scoliosis, which affects 2.5-4% of the North American population. The most symptomatic group of primary presentation ASLS patients are those between the ages of 40 and 80 with lumbar deformities - our target population for this study. This disease constitutes a significant problem in light of our aging population and the high cost of surgical treatment (at least $80,000 in hospital costs alone). Studies to date, however, have typically been limited, small, single institution and retrospective. The extent to which treatment benefits patients with ASLS is not well established. Preliminary data: The Spinal Deformity Study Group/Adult Deformity Outcomes section (SDSG/ADO), which was formed 7 years ago, has developed a multi-center effort specifically to study adult scoliosis and has established an infrastructure for collecting consistent multicenter data. The SDSG has 1) validated a disease-specific outcomes tool (the SRS patient-reported outcomes instrument) for adult spinal deformity; 2) developed and validated disease-specific radiographic tools; 3) analyzed outcomes for certain interventions for comparison of treatments; and 4) collected preliminary data regarding the impact of treatments on patient outcomes. Methods: The study will comprise a multicenter, prospective, randomized controlled trial (RCT) (30%) and consecutive cohort study (70%) of patients receiving current standard-of-care treatments and will use uniform clinical and radiographic assessments that have been validated by our group for assessment of these patients. Both nonoperative and operative care will be stan- dardized within the 5 centers. Quality of life will be assessed by SRS-QOL, ODI, SF-12, numerical rating scale (NRS) back pain and leg pain scores. Functional measures will include a walking treadmill test to assess speed and endurance in patients at baseline and 2 years post-treatment. Primary Aims: Measure the impacts and compare the outcomes of nonoperative and operative treatments in ASLS patients. Innovation: No outcomes study exists in any current peer-reviewed literature to document the effect of both nonoperative and operative treatment on any aspect of primary presentation adult spinal deformity.

摘要

项目成果

Proximal junctional failure in primary thoracolumbar fusion/fixation to the sacrum/pelvis for adult symptomatic lumbar scoliosis: long-term follow-up of a prospective multicenter cohort of 160 patients.

成人症状性腰椎侧凸的原发性胸腰椎融合/骶骨/骨盆固定的近端连接失败：对 160 名患者的前瞻性多中心队列的长期随访。

• DOI: 10.3171/2022.9.spine22549
• 发表时间: 2023
• 期刊: Journal of neurosurgery. Spine
• 作者: Lazaro,Bruno;Sardi,JuanPablo;Smith,JustinS;Kelly,MichaelP;Yanik,ElizabethL;Dial,Brian;Hills,Jeffrey;Gupta,MunishC;Baldus,ChristineR;Yen,ChunPo;Lafage,Virginie;Ames,ChristopherP;Bess,Shay;Schwab,Frank;Shaffrey,Christoph
• 通讯作者: Shaffrey,Christoph

Cost-effectiveness of adult lumbar scoliosis surgery: an as-treated analysis from the adult symptomatic scoliosis surgery trial with 5-year follow-up.

• DOI: 10.1007/s43390-020-00154-w
• 发表时间: 2020-12
• 期刊: Spine deformity
• 影响因子: 1.6
• 作者: Glassman SD;Carreon LY;Shaffrey CI;Kelly MP;Crawford CH 3rd;Yanik EL;Lurie JD;Bess RS;Baldus CR;Bridwell KH
• 通讯作者: Bridwell KH

Baseline Patient-Reported Outcomes Correlate Weakly With Radiographic Parameters: A Multicenter, Prospective NIH Adult Symptomatic Lumbar Scoliosis Study of 286 Patients.

• DOI: 10.1097/brs.0000000000001613
• 发表时间: 2016-11-15
• 期刊: Spine
• 影响因子: 3
• 作者: Chapman TM Jr;Baldus CR;Lurie JD;Glassman SD;Schwab FJ;Shaffrey CI;Lafage V;Boachie-Adjei O;Kim HJ;Smith JS;Crawford CH 3rd;Lenke LG;Buchowski JM;Edwards C 2nd;Koski T;Parent S;Lewis S;Kang DG;McClendon J Jr;Metz L;Zebala LP;Kelly MP;Spratt KF;Bridwell KH
• 通讯作者: Bridwell KH

Health-Related Quality of Life Scores Underestimate the Impact of Major Complications in Lumbar Degenerative Scoliosis Surgery.

• DOI: 10.1016/j.jspd.2017.05.003
• 发表时间: 2018-01
• 期刊: Spine deformity
• 影响因子: 1.6
• 作者: Glassman SD;Bridwell KH;Shaffrey CI;Edwards CC 2nd;Lurie JD;Baldus CR;Carreon LY
• 通讯作者: Carreon LY

Neurologic Deficits Have a Negative Impact on Patient-Related Outcomes in Primary Presentation Adult Symptomatic Lumbar Scoliosis Surgical Treatment at One-Year Follow-up.

神经系统缺陷对成人症状性腰椎侧凸手术治疗一年随访中的患者相关结果有负面影响。

• DOI: 10.1097/brs.0000000000001800
• 发表时间: 2017
• 期刊: Spine
• 影响因子: 3
• 作者: Kang,DanielG;Baldus,Christine;Glassman,StevenD;Shaffrey,ChristopherI;Lurie,JonD;Bridwell,KeithH
• 通讯作者: Bridwell,KeithH