The UAB Sexually Transmitted Infections Cooperative Research Centers (STI CRC)

UAB 性传播感染合作研究中心 (STI CRC)

• 批准号: 8769786
• 负责人: EDWARD W HOOK
• 金额: $ 181.5万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-15 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8769786
• 关键词: Address; Affect; African American; Aftercare; Alabama; Bacteria; Bacterial Vaginosis; Bioinformatics; Biometry; Characteristics; Chlamydia trachomatis; Classification; Clinical; Clinical Management; Data; Development; Diagnosis; Diagnostic; Epithelial Cells; Evaluation; Female; Foundations; Future; Gardnerella vaginalis; Generations; Genetic; Genital system; Goals; Grouping; Health; Housing; Immune response; Infection; Infection Control; Infection prevention; Inflammation; Informatics; Investigation; Knowledge; Laboratories; Lead; Microbe; Molecular; Mucous Membrane; Names; Nonspecific urethritis; Organism; Outcome; Pathogenesis; Patients; Prevention strategy; Recurrence; Research; Research Personnel; Research Project Grants; Resources; Risk; Science; Services; Sexual Partners; Sexually Transmitted Diseases; Signs and Symptoms; Specimen; Subgroup; Symptoms; Syndrome; Testing; Translating; Translational Research; Trichomonas vaginalis; United States; Universities; Ureaplasma urealyticum biovar 1; Vagina; Virulence Factors; Virulent; Woman; Work; assay development; cohort; improved; innovation; men; microbial; microbial community; microbiome; multidisciplinary; novel; pathogen; repository; tool; treatment effect

DESCRIPTION (provided by applicant): This Sexually Transmitted Infections (STI) Cooperative Research Center application from the University of Alabama at Birmingham is comprised of three innovative, multidisciplinary translational research projects addressing the microbial origins and pathogenesis of the most prevalent genital discharge syndromes in men (non-gonococcal urethritis [NGU]) and women (bacterial vaginosis [BV]), as well as interactions of these syndromes with the most prevalent curable bacterial STI, Chlamydia trachomatis (CT). Thus, we named the proposal the "Discharge Syndrome Concordance and Interactions Study" (DiSCIS). Our group of highly productive, established investigators will work together to conduct 3 projects to evaluate patients from a unique cohort of sexual partners: men with (cases) or without (controls) symptomatic NGU and their female partners. We will use cutting edge microbiological and molecular science tools, and rely on integrated clinical, laboratory, and biostatistics/bioinformatics core services. The goal of Project 1 is to advance understanding of the concordance of known STI pathogens and genital microbiome composition within sexual partnerships ("dyads") and the effect of treatment on the microbiome and signs and symptoms of infection. Project 1 hypotheses are: 1) concordance among known STIs is associated with inflammation (NGU), 2) there will be more concordance in microbial community composition within partnerships among those without NGU and following treatment among those with NGU and 3) that certain organisms (Ureaplasma parvum) or microbiome characteristics may help protect from mucosal infection/inflammation. The goal of Project 2 is to advance knowledge of BV pathogenesis through comprehensive evaluation of Gardnerella vaginalis (GV) virulence factors that contribute to infection of vaginal epithelial cells and progression to BV and also to determine classification schema for grouping virulent and avirulent GV strains into distinct clades. The main Project 2 hypothesis is that specific GV virulence factors are associated with BV development. The goal of Project 3 is to advance understanding of the influence of Trichomonas vaginalis (TV) infection and/or BV on CT infection concordance within sexual dyads and the effect of these concomitant infections on CT clearance after treatment and risk for CT infection persistence and/or recurrence. The main Project 3 hypothesis is that CT concordance rates are higher and CT clearance duration longer after therapy in the presence of these concomitant infections. As described in detail in the DiSCIS Overview, the projects are highly complementary and provide substantial value added when performed from the same cohort. Further, a data and specimen repository will be created from these projects that will serve as a powerful resource for future STI studies. DiSCIS findings will provide new knowledge on the pathogenesis of microbes contributing to NGU and BV, and the influence of TV infection and/or BV on CT concordance and outcomes. The long-term goal of the research is to translate findings into improved or new strategies for STI prevention, diagnosis, and/or management.

描述（申请人提供）：这项来自伯明翰亚拉巴马大学的性传播感染（STI）合作研究中心申请由三个创新的多学科转化研究项目组成，旨在解决男性最普遍的生殖器分泌物综合征的微生物起源和发病机制（非淋菌性尿道炎[NGU]）和妇女（细菌性阴道病[BV]）的综合征，以及这些综合征与最流行的可治愈细菌性STI，沙眼衣原体（CT）的相互作用。因此，我们将该提案命名为“出院综合征一致性和相互作用研究”（DisSCIS）。我们的高生产力，建立研究小组将共同开展3个项目，以评估来自一个独特的性伴侣队列的患者：有（病例）或无（对照）症状性NGU的男性及其女性伴侣。我们将使用尖端的微生物学和分子科学工具，并依靠综合临床，实验室和生物统计学/生物信息学核心服务。项目1的目标是促进了解性伴侣关系（“二对”）中已知性传播感染病原体和生殖器微生物组组成的一致性，以及治疗对微生物组和感染体征和症状的影响。项目1的假设是：1）已知STI之间的一致性与炎症（NGU）相关，2）在没有NGU的人中，以及在NGU患者中治疗后，微生物群落组成将更加一致，3）某些生物体（微小脲原体）或微生物组特征可能有助于防止粘膜感染/炎症。项目2的目标是通过综合评价阴道加德纳菌（GV）毒力因子（其有助于感染阴道上皮细胞并进展为BV）来提高对BV发病机制的认识，并确定将强毒和无毒GV菌株分组为不同进化枝的分类方案。项目2的主要假设是特异性GV毒力因子与BV发展相关。项目3的目的是进一步了解阴道毛滴虫（TV）感染和/或BV对性伴侣内CT感染一致性的影响，以及这些合并感染对治疗后CT清除率的影响和CT感染持续和/或复发的风险。项目3的主要假设是，在存在这些合并感染的情况下，治疗后CT一致率更高，CT清除持续时间更长。正如DiSCIS概述中详细描述的那样，这些项目具有高度互补性，并且在同一组群中执行时提供了大量附加值。此外，将利用这些项目建立一个数据和样本库，作为今后科学、技术和创新研究的有力资源。DiSCIS的发现将提供有关导致NGU和BV的微生物发病机制的新知识，以及TV感染和/或BV对CT一致性和结局的影响。研究的长期目标是将研究结果转化为改进的或新的性传播感染预防、诊断和/或管理战略。