Administrative Core

行政核心

• 批准号: 9795000
• 负责人: Rima F Kaddurah-Daouk
• 金额: $ 186.56万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-15 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9795000
• 关键词: Adopted; Advisory Committees; Alzheimer disease detection; Alzheimer' s Disease; Alzheimer' s disease related dementia; American; Biological Markers; Brain; Budgets; Chemicals; Clinical; Clinical Trials; Collection; Communication; Communities; Data; Data Analyses; Data Sources; Databases; Dementia; Doctor of Philosophy; Ensure; Funding; Genetic; Goals; Home environment; Informatics; Infrastructure; Internet; Lead; Leadership; Machine Learning; Medicine; Metadata; Metagenomics; Modeling; Neurologist; Occupational activity of managing finances; Pathogenesis; Patient Care; Phenotype; Planet Earth; Protocols documentation; Research; Research Personnel; Resource Allocation; Resources; Role; Running; Sampling; Schedule; Scientist; Site; Specimen; Structure; Technology; Teleconferences; Time; United States National Institutes of Health; Work; biochemical model; clinical research site; data integration; data management; data sharing; deep learning; digital object identifier; experience; gut microbiome; meetings; metabolomics; microbiome; microbiome analysis; multimodality; neuroimaging; neuropsychiatric disorder; operation; programs; relational database; repository; sample collection; success; tool

ABSTRACT – Administrative Core The Admin Core will provide structure and oversight to enable the Alzheimer’s Gut Microbiome Project to achieve its goal to define the gut-brain-chemical axis of communication and the role for the gut microbiome in Alzheimer’s Disease (AD) pathogenesis. This Core is co-led by Duke’s Rima Kaddurah-Daouk, PhD, UCSD’s Robert Knight, PhD, and UCLA’s Sarkis Mazmanian, PhD, who bring considerable leadership experience and complementary scientific expertise to the U19. Dr. Kaddurah-Daouk will serve as contact PI, and brings experience having successfully led four large NIH-funded consortia and is a pioneer in the application of metabolomics in neuropsychiatric diseases, including defining a role for the gut microbiome in AD. Dr. Knight runs the Earth Microbiome Project and American Gut Project and developed microbiome technologies widely used in the field. Dr. Mazmanian discovered a role for the gut microbiome in the pathogenesis of neuropsychiatric diseases. This team is uniquely qualified to lead and coordinate this large program. Three clinical AD experts (Drs. James Brewer, Andrew Saykin, and Murali Doraiswamy) will provide oversight for all clinical activities including samples collection for national AD research centers and flow of samples through the National Centralized Repository for AD and Related Dementias (NCRAD) center. Through its three Aims, the Admin Core will ensure all Projects and Cores function as an efficient, effective, and integrated whole that all components of the U19 have access to the tools and resources necessary to do the proposed work, and that scientific progress is rapid, rigorous, and efficient. This Core will interact with all U19 Projects and Cores through oversight, governance, and management. Main objectives of the Admin core are the integration of data developed by collaborators through the creation of a relational database to manage all data-related activities as well as the creation of a repository of uniformly collected biospecimens at the NCRAD which will be made available to collaborators as well as the greater research community. Through our discussions, this Core will facilitate rigorous oversight of research and data interpretation. Thus this Core’s activities are critical to our collective success.

摘要-行政核心 管理核心将提供结构和监督，使阿尔茨海默氏症肠道微生物组项目， 实现其目标，以确定肠道-大脑-化学交流轴和肠道微生物组在 阿尔茨海默病（AD）发病机制。该核心由杜克大学的Rima Kaddurah-Daouk博士共同领导， 罗伯特·奈特博士和加州大学洛杉矶分校的萨基斯·马兹马尼安博士，他们带来了丰富的领导经验， 为U19提供科学知识。Kaddurah-Daouk博士将担任联系PI， 成功领导四个大型NIH资助财团的经验，是应用 代谢组学在神经精神疾病中的作用，包括确定肠道微生物组在AD中的作用。奈特医生 运行地球微生物组计划和美国肠道计划，并广泛开发微生物组技术 在现场使用。Mazmanian博士发现了肠道微生物组在胃肠道疾病发病机制中的作用。 神经精神疾病这个团队是唯一有资格领导和协调这个大型项目。三 临床AD专家（James Brewer博士、Andrew Saykin博士和Murali Doraiswamy博士）将为所有人提供监督。 临床活动，包括为国家AD研究中心收集样本，以及通过 国家AD和相关痴呆症集中储存库（NCRAD）中心。通过其三个目标， 管理核心将确保所有项目和核心作为一个高效，有效和综合的整体运作， U19的组成部分可以访问完成拟议工作所需的工具和资源，并且 科学进步迅速，严谨，高效。此核心将与所有U19项目和核心进行交互 通过监督、治理和管理。Admin核心的主要目标是数据集成 由合作者通过建立关系数据库来管理所有与数据有关的活动 以及在NCRAD建立一个统一收集生物标本的储存库， 提供给合作者以及更大的研究社区。通过我们的讨论，这一核心将 促进对研究和数据解释的严格监督。因此，这一核心的活动对我们的 集体的成功。