Administrative Core
行政核心
基本信息
- 批准号:9795000
- 负责人:
- 金额:$ 186.56万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-15 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:AdoptedAdvisory CommitteesAlzheimer disease detectionAlzheimer&aposs DiseaseAlzheimer&aposs disease related dementiaAmericanBiological MarkersBrainBudgetsChemicalsClinicalClinical TrialsCollectionCommunicationCommunitiesDataData AnalysesData SourcesDatabasesDementiaDoctor of PhilosophyEnsureFundingGeneticGoalsHome environmentInformaticsInfrastructureInternetLeadLeadershipMachine LearningMedicineMetadataMetagenomicsModelingNeurologistOccupational activity of managing financesPathogenesisPatient CarePhenotypePlanet EarthProtocols documentationResearchResearch PersonnelResource AllocationResourcesRoleRunningSamplingScheduleScientistSiteSpecimenStructureTechnologyTeleconferencesTimeUnited States National Institutes of HealthWorkbiochemical modelclinical research sitedata integrationdata managementdata sharingdeep learningdigital object identifierexperiencegut microbiomemeetingsmetabolomicsmicrobiomemicrobiome analysismultimodalityneuroimagingneuropsychiatric disorderoperationprogramsrelational databaserepositorysample collectionsuccesstool
项目摘要
ABSTRACT – Administrative Core
The Admin Core will provide structure and oversight to enable the Alzheimer’s Gut Microbiome Project to
achieve its goal to define the gut-brain-chemical axis of communication and the role for the gut microbiome in
Alzheimer’s Disease (AD) pathogenesis. This Core is co-led by Duke’s Rima Kaddurah-Daouk, PhD, UCSD’s
Robert Knight, PhD, and UCLA’s Sarkis Mazmanian, PhD, who bring considerable leadership experience and
complementary scientific expertise to the U19. Dr. Kaddurah-Daouk will serve as contact PI, and brings
experience having successfully led four large NIH-funded consortia and is a pioneer in the application of
metabolomics in neuropsychiatric diseases, including defining a role for the gut microbiome in AD. Dr. Knight
runs the Earth Microbiome Project and American Gut Project and developed microbiome technologies widely
used in the field. Dr. Mazmanian discovered a role for the gut microbiome in the pathogenesis of
neuropsychiatric diseases. This team is uniquely qualified to lead and coordinate this large program. Three
clinical AD experts (Drs. James Brewer, Andrew Saykin, and Murali Doraiswamy) will provide oversight for all
clinical activities including samples collection for national AD research centers and flow of samples through the
National Centralized Repository for AD and Related Dementias (NCRAD) center. Through its three Aims, the
Admin Core will ensure all Projects and Cores function as an efficient, effective, and integrated whole that all
components of the U19 have access to the tools and resources necessary to do the proposed work, and that
scientific progress is rapid, rigorous, and efficient. This Core will interact with all U19 Projects and Cores
through oversight, governance, and management. Main objectives of the Admin core are the integration of data
developed by collaborators through the creation of a relational database to manage all data-related activities
as well as the creation of a repository of uniformly collected biospecimens at the NCRAD which will be made
available to collaborators as well as the greater research community. Through our discussions, this Core will
facilitate rigorous oversight of research and data interpretation. Thus this Core’s activities are critical to our
collective success.
摘要-行政核心
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Rima F Kaddurah-Daouk其他文献
Rima F Kaddurah-Daouk的其他文献
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{{ truncateString('Rima F Kaddurah-Daouk', 18)}}的其他基金
Metabolomic Signatures for Disease Sub-classification and Target Prioritization in AMP-AD
AMP-AD 中疾病亚分类和目标优先级的代谢组学特征
- 批准号:
10084547 - 财政年份:2020
- 资助金额:
$ 186.56万 - 项目类别:
Project 3 - Mechanistic studies on role of gut microbiome in models for Alzheimer's disease
项目 3 - 肠道微生物组在阿尔茨海默病模型中作用的机制研究
- 批准号:
9795005 - 财政年份:2019
- 资助金额:
$ 186.56万 - 项目类别:
Project 3 - Mechanistic studies on role of gut microbiome in models for Alzheimer's disease
项目 3 - 肠道微生物组在阿尔茨海默病模型中作用的机制研究
- 批准号:
10017880 - 财政年份:2019
- 资助金额:
$ 186.56万 - 项目类别:
Project 2 - Influence of controlled diets on gut microbiome, metabolome and cognitive function
项目 2 - 控制饮食对肠道微生物组、代谢组和认知功能的影响
- 批准号:
9795004 - 财政年份:2019
- 资助金额:
$ 186.56万 - 项目类别:
Project 2 - Influence of controlled diets on gut microbiome, metabolome and cognitive function
项目 2 - 控制饮食对肠道微生物组、代谢组和认知功能的影响
- 批准号:
10017878 - 财政年份:2019
- 资助金额:
$ 186.56万 - 项目类别:
Project 1 - Changes in Gut Microbiome and related Metabolome Across Trajectory of Alzheimer's Disease
项目 1 - 阿尔茨海默氏病轨迹中肠道微生物组和相关代谢组的变化
- 批准号:
10017875 - 财政年份:2019
- 资助金额:
$ 186.56万 - 项目类别:
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Standard Grant














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