Administrative Core

行政核心

• 批准号: 9795000
• 负责人: Rima F Kaddurah-Daouk
• 金额: $ 186.56万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-15 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9795000
• 关键词: Adopted; Advisory Committees; Alzheimer disease detection; Alzheimer' s Disease; Alzheimer' s disease related dementia; American; Biological Markers; Brain; Budgets; Chemicals; Clinical; Clinical Trials; Collection; Communication; Communities; Data; Data Analyses; Data Sources; Databases; Dementia; Doctor of Philosophy; Ensure; Funding; Genetic; Goals; Home environment; Informatics; Infrastructure; Internet; Lead; Leadership; Machine Learning; Medicine; Metadata; Metagenomics; Modeling; Neurologist; Occupational activity of managing finances; Pathogenesis; Patient Care; Phenotype; Planet Earth; Protocols documentation; Research; Research Personnel; Resource Allocation; Resources; Role; Running; Sampling; Schedule; Scientist; Site; Specimen; Structure; Technology; Teleconferences; Time; United States National Institutes of Health; Work; biochemical model; clinical research site; data integration; data management; data sharing; deep learning; digital object identifier; experience; gut microbiome; meetings; metabolomics; microbiome; microbiome analysis; multimodality; neuroimaging; neuropsychiatric disorder; operation; programs; relational database; repository; sample collection; success; tool

ABSTRACT – Administrative Core The Admin Core will provide structure and oversight to enable the Alzheimer’s Gut Microbiome Project to achieve its goal to define the gut-brain-chemical axis of communication and the role for the gut microbiome in Alzheimer’s Disease (AD) pathogenesis. This Core is co-led by Duke’s Rima Kaddurah-Daouk, PhD, UCSD’s Robert Knight, PhD, and UCLA’s Sarkis Mazmanian, PhD, who bring considerable leadership experience and complementary scientific expertise to the U19. Dr. Kaddurah-Daouk will serve as contact PI, and brings experience having successfully led four large NIH-funded consortia and is a pioneer in the application of metabolomics in neuropsychiatric diseases, including defining a role for the gut microbiome in AD. Dr. Knight runs the Earth Microbiome Project and American Gut Project and developed microbiome technologies widely used in the field. Dr. Mazmanian discovered a role for the gut microbiome in the pathogenesis of neuropsychiatric diseases. This team is uniquely qualified to lead and coordinate this large program. Three clinical AD experts (Drs. James Brewer, Andrew Saykin, and Murali Doraiswamy) will provide oversight for all clinical activities including samples collection for national AD research centers and flow of samples through the National Centralized Repository for AD and Related Dementias (NCRAD) center. Through its three Aims, the Admin Core will ensure all Projects and Cores function as an efficient, effective, and integrated whole that all components of the U19 have access to the tools and resources necessary to do the proposed work, and that scientific progress is rapid, rigorous, and efficient. This Core will interact with all U19 Projects and Cores through oversight, governance, and management. Main objectives of the Admin core are the integration of data developed by collaborators through the creation of a relational database to manage all data-related activities as well as the creation of a repository of uniformly collected biospecimens at the NCRAD which will be made available to collaborators as well as the greater research community. Through our discussions, this Core will facilitate rigorous oversight of research and data interpretation. Thus this Core’s activities are critical to our collective success.

抽象--管理核心 管理核心将提供结构和监督，使阿尔茨海默氏症肠道微生物组项目能够 实现定义肠道-脑-化学轴的目标以及肠道微生物群在 阿尔茨海默病(AD)的发病机制。这个核心是由杜克大学的Rima Kaddurah-Daouk，博士，UCSD的共同领导的 罗伯特·奈特博士和加州大学洛杉矶分校的Sarkis Mazmanian博士，他们带来了丰富的领导经验和 与U19相辅相成的科学专长。Kaddurah-Daouk博士将担任联系人Pi，并带来 成功领导了四个由美国国立卫生研究院资助的大型财团，是应用 神经精神疾病的代谢组学，包括确定肠道微生物组在AD中的作用。奈特博士 主持地球微生物组计划和美国肠道计划，广泛开发微生物组技术 在野外使用。马兹马尼亚博士发现肠道微生物群在霍乱的发病机制中发挥了作用。 神经精神疾病。这个团队是唯一有资格领导和协调这一大型项目的团队。三 临床AD专家(詹姆斯·布鲁尔、安德鲁·塞金和穆拉利·多莱斯瓦米博士)将为所有 临床活动包括为国家AD研究中心收集样本和通过 国家AD及相关痴呆症中央资料库(NCRAD)中心。通过它的三个目标， 管理核心将确保所有项目和核心作为一个高效、有效和集成的整体运行 U19的部件可以获得完成拟议工作所需的工具和资源，并且 科学进步是快速、严谨、高效的。该核心将与所有U19项目和核心互动 通过监督、治理和管理。管理核心的主要目标是整合数据 由协作者通过创建关系数据库来开发，以管理所有与数据相关的活动 以及在NCRAD创建一个统一收集的生物标本储存库，这将使 可供合作者以及更大的研究社区使用。通过我们的讨论，这个核心将 促进对研究和数据解释的严格监督。因此，这个核心的活动对我们的 集体成功。