Measuring and Mapping Intravoxel Incoherent Motion (IVIM) via MRI from a Porous Media NMR Perspective

从多孔介质 NMR 角度通过 MRI 测量和绘制体素内不相干运动 (IVIM)

• 批准号: 9796390
• 负责人: Nathan Williamson
• 金额: --
• 依托单位: U.S. NATIONAL INST/CHILD HLTH/HUMAN DEV
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9796390
• 关键词: Address; Blood; Blood Circulation; Blood Volume; Blood capillaries; Blood flow; Cells; Characteristics; Clinic; Clinical; Clinical Protocols; Data; Detection; Diagnosis; Diagnostic; Diagnostic Procedure; Diffuse; Diffusion; Diffusion Magnetic Resonance Imaging; Discipline of obstetrics; Disease; Doppler velocimetry; Excision; Galanin; Goals; Histologic; Image; Length; Lesion; Liquid substance; Magnetic Resonance Imaging; Malignant Neoplasms; Maps; Measurement; Measures; Methods; Modeling; Molecular; Morphologic artifacts; Motion; Nuclear Magnetic Resonance; Nutrient; Oxygen; Pathology; Patients; Perfusion; Placenta; Plant Roots; Play; Pre-Eclampsia; Pregnancy Complications; Pregnant Women; Prostate; Prostatic Neoplasms; Protocols documentation; Reproducibility; Research; Research Proposals; Role; Sensitivity and Specificity; Signal Transduction; Sum; Testing; Tissue imaging; Tissues; Waste Products; Water; base; blood perfusion; capillary bed; clinical application; clinical translation; clinically relevant; design; expectation; fetal blood; fluid flow; imaging modality; indexing; noninvasive diagnosis; oncology; perfusion imaging; radiologist; theories; tool; vascular bed

Blood perfusion through the capillary bed is the final transport step before nutrients and oxygen diffuse to cells, and the first step for removal of waste products diffusing away from cells. The ability to non-invasively measure perfusion characteristics such as blood volume and velocity is important clinically since perfusion plays a role in many pathologies. Perfusion imaging by intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) was proposed over thirty years ago, however, acceptance of IVIM MRI has lagged due to poor reproducibility of IVIM perfusion metrics. The objective of this project is to approach the problem of poor reproducibility by using porous media nuclear magnetic resonance (NMR) theory to develop IVIM MRI methods that correctly model the types of fluid motions that occur during perfusion. The methods will be optimized on well-defined phantoms to evaluate the ability to measure perfusion characteristics. Then the perfusion imaging methods will be applied to prostate tumors and placentas complicated by preeclampsia. The project is anticipated to have a significant positive impact on the clinical capability and utility of IVIM MRI.

通过毛细血管床的血液灌注是营养和氧气之前的最后运输步骤

项目成果

Limits to flow detection in phase contrast MRI.

相衬 MRI 中血流检测的限制。

• DOI: 10.1016/j.jmro.2020.100004
• 发表时间: 2020
• 期刊: Journal of magnetic resonance open
• 作者: Williamson,NathanH;Komlosh,MichalE;Benjamini,Dan;Basser,PeterJ
• 通讯作者: Basser,PeterJ

Interrogating the relationship between the microstructure of amphiphilic poly(ethylene glycol-b-caprolactone) copolymers and their colloidal assemblies using non-interfering techniques.

• DOI: 10.1016/j.jcis.2021.08.084
• 发表时间: 2022-01-15
• 期刊: Journal of colloid and interface science
• 影响因子: 9.9
• 作者: Faisal KS;Clulow AJ;Krasowska M;Gillam T;Miklavcic SJ;Williamson NH;Blencowe A
• 通讯作者: Blencowe A