Measuring and Mapping Intravoxel Incoherent Motion (IVIM) via MRI from a Porous Media NMR Perspective

通过毛细血管床的血液灌注是营养物质和氧气之前的最后运输步骤 扩散到细胞，第一步是去除扩散离开细胞的废物。的 非侵入性地测量诸如血容量和速度的灌注特性的能力 因为灌注在许多病理学中起作用，所以在临床上是重要的。灌注成像， 体素内非相干运动（IVIM）磁共振成像（MRI）被提出， 然而，30年前，IVIM MRI的接受已经滞后，因为其再现性差， IVIM灌注指标。该项目的目标是解决贫困问题， 利用多孔介质核磁共振（NMR）理论， IVIM MRI方法可正确模拟灌注期间发生的流体运动类型。 这些方法将在定义明确的体模上进行优化，以评价测量能力 灌注特性然后将灌注成像方法应用于前列腺 肿瘤和胎盘并发先兆子痫。该项目预计将有一个 对IVIM MRI的临床能力和实用性产生了显著的积极影响。

Blood perfusion through the capillary bed is the final transport step before nutrients and oxygen diffuse to cells, and the first step for removal of waste products diffusing away from cells. The ability to non-invasively measure perfusion characteristics such as blood volume and velocity is important clinically since perfusion plays a role in many pathologies. Perfusion imaging by intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) was proposed over thirty years ago, however, acceptance of IVIM MRI has lagged due to poor reproducibility of IVIM perfusion metrics. The objective of this project is to approach the problem of poor reproducibility by using porous media nuclear magnetic resonance (NMR) theory to develop IVIM MRI methods that correctly model the types of fluid motions that occur during perfusion. The methods will be optimized on well-defined phantoms to evaluate the ability to measure perfusion characteristics. Then the perfusion imaging methods will be applied to prostate tumors and placentas complicated by preeclampsia. The project is anticipated to have a significant positive impact on the clinical capability and utility of IVIM MRI.