Measuring and Mapping Intravoxel Incoherent Motion (IVIM) via MRI from a Porous Media NMR Perspective

通过毛细血管床的血液灌流是营养物质和氧气之前的最后运输步骤。 扩散到细胞，以及清除从细胞扩散出去的废物的第一步。这个 非侵入性测量血流容量和血流速度等血流特征的能力 由于血流灌注在许多病理中起作用，因此在临床上很重要。灌注成像方法： 体素内非相干运动(IVIM)磁共振成像(MRI)是在 然而，30年前，由于IVIM MRI的重复性差，人们对IVIM MRI的接受程度一直滞后 IVIM血流灌注指标。这个项目的目标是解决贫困人口的问题 利用多孔介质核磁共振理论发展重复性 IVIM MRI方法可以正确模拟在灌流过程中发生的液体运动的类型。 这些方法将在定义良好的模体上进行优化，以评估测量能力 血流灌注特性。然后将灌注成像方法应用于前列腺 肿瘤和胎盘合并先兆子痫。该项目预计将有一个 对IVIM MRI的临床能力和实用性产生了显著的积极影响。

Blood perfusion through the capillary bed is the final transport step before nutrients and oxygen diffuse to cells, and the first step for removal of waste products diffusing away from cells. The ability to non-invasively measure perfusion characteristics such as blood volume and velocity is important clinically since perfusion plays a role in many pathologies. Perfusion imaging by intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) was proposed over thirty years ago, however, acceptance of IVIM MRI has lagged due to poor reproducibility of IVIM perfusion metrics. The objective of this project is to approach the problem of poor reproducibility by using porous media nuclear magnetic resonance (NMR) theory to develop IVIM MRI methods that correctly model the types of fluid motions that occur during perfusion. The methods will be optimized on well-defined phantoms to evaluate the ability to measure perfusion characteristics. Then the perfusion imaging methods will be applied to prostate tumors and placentas complicated by preeclampsia. The project is anticipated to have a significant positive impact on the clinical capability and utility of IVIM MRI.