Human Heredity and Health in Africa Consortium Biorepository

项目摘要 非洲人类遗传与健康(H3Africa)是由两个国家资助成立的 卫生研究所共同基金和惠康信托基金，目的是扩大基因组 非洲大陆的研究和研究能力。受资助项目的一个重要组成部分 在H3非洲是数据和生物群落共享，并确保收集生物群落和 为进一步的研究储存起来，建立了生物信息库。H3非洲生物库，位于 临床实验室服务(CLS)是第一个扩大规模以满足H3非洲需求的设施 项目。它利用了现有的生物存储库基础架构，该基础架构在CLS由 符合GCLP标准的临床病理服务和临床试验部门。CLS是 威特沃特斯兰德大学的研究部，威茨健康联盟(WHC)，它提供 为CLS的所有项目提供行政和法律援助。2014年起的资助期内- 2019年，CLS生物库的基础设施得到了相当大的扩展，技术专长 是发展起来的。第一阶段所有来自NIH资助项目的样本都被收集、运输 并按照最佳做法以及道德、法律和社会考虑进行储存 在非洲的仓库。 CLS的H3非洲生物储存库第二阶段供资的目标是继续 为来自H3非洲的基因组DNA和其他类型的样本提供高质量的存储设施 项目，同时继续为临床试验、制药行业和其他研究储备 与其业务模式和具有竞争力的按服务收费定价结构保持一致。这个 生物信息库扩大了其增值样本处理设施，包括Next- 世代测序能力、自动核酸提取和稀有细胞群分类 旨在为研究人员提供这些服务，同时建设能力和技术能力。 它还在开发针对非洲的生物信息库科学培训材料。CLS生物资源库 正在积极与各机构(包括威特沃特斯兰德大学和比勒陀利亚大学)合作， 国家政府(包括卫生部和科技部)和 包括非洲联盟在内的区域结构，以确保生物库基础设施 维持作为区域资源，并将继续倡导在#年建立非洲生物库 国际和地区论坛，包括国际生物和自然资源学会 环境资源库。

Project Summary Human Heredity and Health in Africa (H3Africa) was established with funding from both the National Institutes of Health Common Fund and the Wellcome Trust with the aim of expanding genomic research and research capacity on the Africa continent. A key component of the projects funded under H3Africa is data and biospecimen sharing and to ensure that biospecimens were collected and stored for additional research, biorepositories were established. The H3Africa Biorepository at Clinical Laboratory Services (CLS) was the first facility to be scaled-up to meet the needs of H3Africa projects. It leveraged on an existing biorepository infrastructure which was supported at CLS by a GCLP-compliant clinical pathology service and clinical trials division. CLS is a division of the University of Witwatersrand’s research division, the Wits Health Consortium (WHC) which provides administrative and legal assistance to all of CLS’s projects. During the funding period from 2014- 2019, the infrastructure at the CLS biorepository was expanded considerably and technical expertise was developed. All samples from NIH-funded projects in the first phase were collected, transported and stored in alignment with best practice and with the ethical, legal and societal considerations of storage in Africa. The goal of the H3Africa biorepository at CLS for the second phase of funding is to continue to provide a high-quality storage facility for genomic DNA and other sample types from the H3Africa projects while continuing to store for clinical trials, pharmaceutical industry and other research partners in alignment with its business model and competitive fee-for-service pricing structure. The biorepository has expanded its value-added sample processing facilities by including Next- Generation Sequencing capacity, automated nucleic acid extraction and rare cell population sorting and aims to provide these services to researchers while building capacity and technical competence. It is also developing Africa-specific training material for biorepository science. The CLS biorepository is actively partnering with institutions (including the Universities of Witwatersrand and Pretoria), national government (including the Departments of Health and Science and Technology) and regional structures including the African Union to ensure that the biorepository infrastructure is maintained as a regional resource and will continue to advocate for African biorepositories in international and regional forums including the International Society of Biological and Environmental Repositories.