Clinical trial of a disinfectant intervention in therapy dogs to combat hospital-associated pathogens and promote sustainability of Animal-Assisted visitation programs

对治疗犬进行消毒干预的临床试验，以对抗医院相关病原体并促进动物辅助探视计划的可持续性

• 批准号: 9794756
• 负责人: Meghan F. Davis
• 金额: $ 60.33万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-28 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9794756
• 关键词: Animal Welfare; Animals; Anxiety; Back; Bacteria; Bathing; Blood Pressure; Canis familiaris; Child; Chlorhexidine; Clinical Trials; Clostridium difficile; Colony-forming units; Communities; Complementary therapies; Control Groups; Data; Development; Disease; Disinfectants; Dorsal; Effectiveness; Emotional; Enrollment; Fostering; Genus staphylococcus; Goals; Group Therapy; Guidelines; Heart Rate; Hospital Nursing; Hospitals; Human; Human Pathology; Infection Control; Infectious Agent; Intervention; Malignant Neoplasms; Mental disorders; Nose; Nursing Homes; Nursing Schools; Outpatients; Pain; Participant; Patient Care; Patient Self-Report; Patients; Pediatric Oncology; Persons; Phase; Pilot Projects; Pseudomonas aeruginosa; Randomized; Randomized Controlled Trials; Recommendation; Reporting; Risk; Risk Factors; Running; Stress; Testing; Visit; Work; arm; base; blood pressure reduction; combat; cost; health care settings; immune function; improved outcome; intervention program; methicillin resistant Staphylococcus aureus; microbial community; microbiota; pathogen; pediatric patients; pet animal; programs; transmission process; uptake; welfare

PROJECT SUMMARY Hospital-based Animal-Assisted visitation programs provide an important complementary treatment in holistic patient care and reduce reduce patient stress, pain and anxiety. However, the risk of transmission of pathogens, such as methicillin-resistant Staphylococcus aureus, is a challenge to the sustainability of hospital- based Animal-Assisted visitation programs. Our pilot data suggest that a low-cost chlorhexidine-based intervention targeted to the dogs involved in the visitation programs holds high potential to reduce pathogen transmission during sessions. Therefore, we will enroll child participants who interact with 50 dogs over twelve sessions (six observational, six where the dog is randomized to intervention or control) at two enrollment centers. We will test the following aims: 1) To identify program-related risk factors for acquisition of hospital- associated pathogens by pediatric patients during AAI sessions during an initial run-in phase of no intervention; 2) To determine the effect of a chlorhexidine (CHX)-based intervention on acquisition of hospital-associated pathogens and microbial communities by patients during AAI sessions via a multicenter randomized controlled trial; and 3) To determine whether the specific benefits achieved by the visitation program, i.e. reduction in blood pressure, heart rate and self-reported pain and anxiety, are impacted by the intervention. If findings support the hypothesis that this intervention is effective to reduce pathogen transmission through a multicenter, parallel-arm randomized controlled trial and does not reduce Animal-Assisted visitation program benefits to the children or impact the welfare of the therapy dogs, then we will have strong evidence on which to base recommendations for infection control guidelines for programs nationally.!

项目总结