The ShEEP request for Waters Xevo TQ-XS Liquid Chromatography Mass Spectrometer System

该ShEEP申请要求资金购买Acquity UPLC Xevo TQ-XS LCMS Mass 光谱仪，将用于支持退伍军人事务部的研究在亨特霍姆斯麦奎尔医疗中心。 包括周博士、潘达克博士、赫勒蒙博士、巴贾杰博士和任博士在内的五位VA资助的主要研究人员要求这样做 测量胆汁酸，氧化固醇和脂质的设备，用于他们资助的VA优异奖和NIH 赠款。目前，没有LC/MC可在麦奎尔VA医疗中心。Xevo® TQ-XS是一款 先进的台式串联四极杆质谱仪，扩大了最终的范围 在生物医学研究项目中遇到的复杂矩阵的灵敏度分析。这 设备支持生物医学研究，需要深入了解关键的生物化学品相关 疾病的传播途径。这项研究的一个主要方面涉及准确的，可重复的测量， 这些生化物质在生物样品中的含量很低。Acquity UPLC Xevo TQ-XS LCMS质量 光谱仪专门设计用于提供这些类型的质量测量，以支持 这样的研究。Acquity UPLC Xevo TQ-XS LCMS质谱仪采用StepWave XS™ 离子转移光学器件，提供增强的灵敏度、鲁棒性和可靠性;被动去除气体 负载和不需要的中性污染物，同时主动地将离子转移到质量分析器中。 由于Xevo TQ-XS还采用免工具探头设计，因此更容易获得灵敏度优势 这使得用户更容易维护，优化和提高再现性之间 运营商扩展动态范围使方法转移到Xevo TQ-XS上变得简单 (XDR™）检测器，其允许六阶线性动态范围。当这些进步结合在一起 允许在最低浓度下对分析物进行新水平的可重现和准确定量。的 2D技术功能，用于捕获、心脏切割、平行柱再生、柱处 稀释、时间去偶联色谱和2D综合色谱， 增强iClass UPLC LC系统Xevo TQ XS系统的分析分离能力 提供解决生物样品LCMSMS分析中的复杂性所需的多功能性。 结合这两种生物分析适当的技术提供了仪器的能力 成功完成这些与代谢性肝病相关的资助研究所需的 退伍军人事务部研究使命的目标区域。

This ShEEP application requested fund to purchase a Acquity UPLC Xevo TQ-XS LCMS Mass Spectrometer that will be used to support VA research at the Hunter Holmes McGuire Medical Center. Five major VA-funded investigators including Drs. Zhou, Pandak, Hylemon, Bajaj and Ren require this equipment to measure bile acids, oxysterols and lipids for their funded VA Merit Awards and NIH grants. Currently, no LC/MC is available at McGuire VA Medical Center. The Xevo® TQ-XS is an advanced benchtop tandem quadrupole mass spectrometer which expands the scope of ultimate sensitivity analysis in the complex matricies encountered in biomedical research programs . This equipment supports biomedical research that requires intimate knowledge of key biochemicals related to disease pathways. A major aspect of this research involves accurate, reproducible measurements of such biochemicals at low levels in biological samples. The Acquity UPLC Xevo TQ-XS LCMS Mass Spectrometer was specifically designed to provide these types of quality measurements in support of such research. The Acquity UPLC Xevo TQ-XS LCMS Mass Spectrometer features StepWave XS™ ion transfer optics delivering enhanced sensitivity, robustness, and reliability; passively removing gas load and undesirable neutral contaminants while actively transferring ions into the mass analyzer. Sensitivity benefits are more accessible as the Xevo TQ-XS also features a tool-free probe design which allows users much easier maintenance, optimization and improved reproducibility between operators. Method transfer onto the Xevo TQ-XS is made simple by the Xtended Dynamic Range (XDR™) detector which allows six orders of linear dynamic range. When combined these advances allow new levels of reproducible and accurate quantitation of analytes at the lowest concentrations. The 2D Technology functions for Trapping, Heart Cutting, Parallel Column Regeneration, At-Column Dilution, Time de-coupled chromatography and 2D Comprehensive chromatography which further enhance the analytical separation capability of the iClass UPLC LC system Xevo TQ XS system providing the versatility needed to address the complexity in biological sample LCMSMS analysis. Combining these two bioanalytically appropriate technologies provides the instrumental capabilities required for successful completion of these funded studies related to metabolic liver diseases that are target areas of the VA research mission.