Indiana University Melvin and Bren Simon Cancer Center Support Grant

摘要、概述和基本特征 IU西蒙癌症中心是一个NCI指定的癌症中心，致力于癌症研究， 教育和病人护理的公民印第安纳州和超越。自我们上次审查以来，IUSCC已 大大增加了我们的科学和癌症相关研究的深度和广度， NCI资金（直接成本）增加38%，我们的多PI赠款增加176%，同时吸引了30多个 癌症研究的新研究员我们是国内第一个 关注儿科肿瘤的SPORE是三个活跃的癌症联盟的发源地，其中一个 连接来自北美和撒哈拉以南非洲的研究人员。IUSCC由两个基本程序组成， 造血和血液肿瘤（HHM）和肿瘤微环境和转移（TMM），以及 两个翻译计划，实验和发展治疗（EDT）和癌症预防， 对照（CPC）。我们将我们的集水区定义为整个印第安纳州，因为患者来自 92个县和89%的县至少有一名患者进入临床试验。 我们的社区外展和参与活动的重点是印第安纳州的城市和农村人口 与该州死亡率最高的疾病（即肺癌、乳腺癌和胃肠道癌）有关， 作为行为风险因素，对筛查和预防产生不利影响（例如烟草和HPV 疫苗）。我们专注于开发新的方法，用于筛查，治疗和症状科学， “精确医学”和扩大生物信息学和医学信息学的工作，以解决日益增加的 理解基因组和临床数据的复杂性。我们的愿景是， 印第安纳州和全球的劳动力，通过教育，从“青少年到终身教职”和整合的临床和 在我们的战略计划中进行转化研究。这项战略计划以教育为基础， 对我们的集水区的影响，由四个支柱组成，这是IUSCC的基础。这些支柱 包括：1）生物学到床边研究; 2）;精准医学; 3）预防，早期发现和人口 健康：地方-全球方法;和4）卫生保健差异，生存和症状科学。

ABSTRACT, Overview and Essential Characteristics The IU Simon Cancer Center is an NCI-designated Cancer Center that is dedicated to cancer research, education, and patient care for the citizens of Indiana and beyond. Since our last review, the IUSCC has substantially increased the depth and breadth of our science and cancer relevant research as evidenced by over a 38% increase in NCI funding (Direct Costs), a 176% increase in our multi-PI grants while attracting over 30 new investigators in cancer research to our institution. We are the home to the country's first pathway-driven SPORE that focuses on pediatric tumors and the birthplace to three active cancer consortia, including one that links researchers from North America and sub-Saharan Africa. The IUSCC is composed of two basic programs, Hematopoiesis and Hematologic Malignancies (HHM) and Tumor Microenvironment and Metastasis (TMM), and two translational programs, Experimental and Developmental Therapeutics (EDT) and Cancer Prevention and Control (CPC). We define our catchment area as the entire state of Indiana as patients come from each of the 92 counties and 89% of the counties have at least one patient entered on clinical trials. Our community outreach and engagement activities have focused on the urban and rural populations of Indiana with the diseases with the highest mortality in the state, (i.e. lung, breast and gastrointestinal cancers) as well as behavioral risk factors, which adversely impact screening and prevention (e.g. tobacco and HPV vaccinations). We focus on developing novel approaches for screening, treatment and symptom science using "precision medicine" and expanding work in bioinformatics and medical informatics to address the increasing complexity of understanding the genomic and clinical data. We embrace the vision of increasing the research workforce in Indiana and globally through education from "Teens-to-Tenure" and the integration of clinical and translational research in our strategic plan. This strategic plan, which has its underpinnings with education and impact to our catchment area, is composed of four pillars that are foundational to the IUSCC. These pillars include: 1) Biology to Bedside Research; 2); Precision Medicine; 3) Prevention, Early Detection and Population Health: Local-Global Approaches; and 4) Health Care Disparities, Survivorship, and Symptom Science.