Indiana University Melvin and Bren Simon Cancer Center Support Grant

印第安纳大学梅尔文和布伦西蒙癌症中心支持补助金

• 批准号: 9793151
• 负责人: PATRICK J. LOEHRER
• 金额: $ 275.97万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-22 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9793151
• 关键词: Address; Affect; Africa South of the Sahara; African American; American Cancer Society; Area; Asians; Automobile Driving; Basic Science; Behavioral; Bioinformatics; Biological; Biology; Breast; Cancer Burden; Cancer Center; Cancer Center Support Grant; Cancer Control; Cancer Control Research; Cancer Etiology; Carcinogenesis Mechanism; Catchment Area; Censuses; Cessation of life; Characteristics; Clinical Data; Clinical Research; Clinical Trials; Colorectal; Communities; Community Outreach; Country; County; Developmental Therapeutics Program; Direct Costs; Disease; Drug resistance; Early Diagnosis; Education; Educational Activities; Environment; Foundations; Funding; Geography; Goals; Grant; Health Policy; Health Professional; Hematologic Neoplasms; Hematopoiesis; Hispanics; Home environment; Human Papillomavirus; Incidence; Indiana; Institution; Interdisciplinary Study; Investigational Therapies; Latino; Lead; Link; Lung; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Malignant neoplasm of gastrointestinal tract; Malignant neoplasm of lung; Malignant neoplasm of pancreas; Medical Informatics; Mission; Modeling; Morbidity - disease rate; NCI-Designated Cancer Center; Neoplasm Metastasis; North America; Pancreas; Pathway interactions; Patient Care; Patient-Centered Care; Patients; Pediatric Neoplasm; Population; Prevention; Research; Research Personnel; Research Training; Resource Sharing; Risk Behaviors; Risk Factors; Rural Population; Science; Smoking; Strategic Planning; Teenagers; Therapeutic; Tobacco; Translational Research; Underrepresented Minority; Underserved Population; Universities; Urban Population; Vaccination; Vision; Work; anticancer research; cancer health disparity; cancer prevention; clinical care; clinical development; fundamental research; gastrointestinal; genomic data; health care disparity; innovation; malignant breast neoplasm; mortality; mortality disparity; novel; novel strategies; oncology; outreach; population health; precision medicine; programs; screening; socioeconomics; survivorship; symptom science; training opportunity; translational research program; tumor microenvironment; working group

ABSTRACT, Overview and Essential Characteristics The IU Simon Cancer Center is an NCI-designated Cancer Center that is dedicated to cancer research, education, and patient care for the citizens of Indiana and beyond. Since our last review, the IUSCC has substantially increased the depth and breadth of our science and cancer relevant research as evidenced by over a 38% increase in NCI funding (Direct Costs), a 176% increase in our multi-PI grants while attracting over 30 new investigators in cancer research to our institution. We are the home to the country's first pathway-driven SPORE that focuses on pediatric tumors and the birthplace to three active cancer consortia, including one that links researchers from North America and sub-Saharan Africa. The IUSCC is composed of two basic programs, Hematopoiesis and Hematologic Malignancies (HHM) and Tumor Microenvironment and Metastasis (TMM), and two translational programs, Experimental and Developmental Therapeutics (EDT) and Cancer Prevention and Control (CPC). We define our catchment area as the entire state of Indiana as patients come from each of the 92 counties and 89% of the counties have at least one patient entered on clinical trials. Our community outreach and engagement activities have focused on the urban and rural populations of Indiana with the diseases with the highest mortality in the state, (i.e. lung, breast and gastrointestinal cancers) as well as behavioral risk factors, which adversely impact screening and prevention (e.g. tobacco and HPV vaccinations). We focus on developing novel approaches for screening, treatment and symptom science using "precision medicine" and expanding work in bioinformatics and medical informatics to address the increasing complexity of understanding the genomic and clinical data. We embrace the vision of increasing the research workforce in Indiana and globally through education from "Teens-to-Tenure" and the integration of clinical and translational research in our strategic plan. This strategic plan, which has its underpinnings with education and impact to our catchment area, is composed of four pillars that are foundational to the IUSCC. These pillars include: 1) Biology to Bedside Research; 2); Precision Medicine; 3) Prevention, Early Detection and Population Health: Local-Global Approaches; and 4) Health Care Disparities, Survivorship, and Symptom Science.

摘要、概述和基本特征 印第安纳大学西蒙癌症中心是 NCI 指定的癌症中心，致力于癌症研究， 为印第安纳州及其他地区的公民提供教育和患者护理。自上次审查以来，IUSCC 已 大大增加了我们的科学和癌症相关研究的深度和广度，以上证据表明 NCI 资金（直接成本）增加 38%，我们的多 PI 赠款增加 176%，同时吸引了 30 多个 我们机构的癌症研究新研究者。我们是全国第一个路径驱动的发源地 SPORE 专注于儿童肿瘤，也是三个活跃癌症联盟的诞生地，其中一个 将来自北美和撒哈拉以南非洲的研究人员联系起来。 IUSCC 由两个基本项目组成， 造血和血液恶性肿瘤 (HHM) 以及肿瘤微环境和转移 (TMM)，以及 两个转化项目，实验和发育治疗（EDT）和癌症预防和 控制（每次点击费用）。我们将我们的服务区域定义为整个印第安纳州，因为患者来自各个州 92个县和89%的县至少有一名患者参加临床试验。 我们的社区外展和参与活动主要针对印第安纳州的城市和农村人口 以及该州死亡率最高的疾病（即肺癌、乳腺癌和胃肠道癌症） 作为行为风险因素，对筛查和预防产生不利影响（例如烟草和 HPV） 疫苗接种）。我们专注于开发用于筛查、治疗和症状科学的新方法 “精准医疗”并扩大生物信息学和医学信息学工作，以解决日益增长的问题 理解基因组和临床数据的复杂性。我们拥抱增加研究的愿景 通过“青少年到终身教职”的教育以及临床和临床实践的整合，在印第安纳州和全球范围内培养劳动力 我们战略计划中的转化研究。这一战略计划以教育和 对我们流域的影响，由 IUSCC 的四大支柱组成。这些支柱 包括：1）生物学到临床研究； 2）；精准医学； 3) 预防、早期发现和人口 健康：地方-全球方法； 4) 医疗保健差异、生存率和症状科学。