Core 1: Diagnostic Immunopathology and Imaging Core

核心 1：诊断免疫病理学和成像核心

• 批准号: 9793477
• 负责人: Peter M Sadow
• 金额: $ 17.01万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9793477
• 关键词: Address; Aerodigestive Tract; Biological; Blood; Cells; Combination immunotherapy; Communities; Diagnostic; Ear; Ensure; Eye; General Hospitals; Goals; Guidelines; Head and Neck Cancer; Head and Neck Squamous Cell Carcinoma; Head and neck structure; Histologic; Human; Image; Inflammatory; Larynx; Liquid substance; Massachusetts; Methodology; Neoplasms; Oral cavity; Oropharyngeal; Pathology; Patient Care; Patients; Peer Review; Process; Publications; Reaction; Research; Research Personnel; Resources; Site; Specimen; Time; Tissues; Translational Research; Tumor-Infiltrating Lymphocytes; Work; World Health Organization; clinical care; clinically relevant; design; human tissue; immune resistance; immunopathology; innovation; neoplastic; novel; programs; sample collection; success; translational impact; tumor

ABSTRACT - DIAGNOSTIC IMMUNOPATHOLOGY AND IMAGING CORE A concerted effort to collect and bank well-characterized high-quality human tissues from the upper aerodigestive tract, including oral cavity, larynx, and oropharynx, has been an ongoing goal by Pathology at the MGH and MEE since 1990. Over time, specimen collection has evolved to more specific targeting of tissues and biologic fluids. Furthermore, the focus is shifting to the stromal component and especially the host inflammatory reaction including tumor infiltrating lymphocytes. The overall availability of these human tissues and cells has contributed to the work of many of the investigators participating in head and neck research efforts and resulting over the years in significant discoveries with high translational impact and numerous peer- reviewed publications. The Diagnostic Immunopathology and Imaging (DIIC) Core will continue to: 1) collect, store, process and distribute tissues and biologic fluids for translational research without compromise of patient care; 2) provide well-characterized tumors with respect to site of origin and World Health Organization histologic subtype and differentiation; 3) provide normal control tissue in addition to neoplasms; 4) process and store tissues to address the requirements of all investigators; 5) collect matched blood from pertinent patients for core projects; 6) provide the specimens in a timely fashion; and 7) provide well-defined mechanisms for prioritization of the distribution of requested resources to the Program Project investigators.

摘要-诊断免疫病理学和成像核心 共同努力收集和储存来自上层的特征良好的高质量人体组织， 呼吸消化道，包括口腔、喉和口咽，一直是病理学的目标。 1990年以来的MGH和ESTA。随着时间的推移，标本采集已经发展到更具体的组织靶向 和生物液体。此外，焦点正在转移到基质成分，特别是宿主 炎症反应，包括肿瘤浸润淋巴细胞。这些人体组织的总体可用性 和细胞为许多参与头颈部研究的研究人员的工作做出了贡献 多年来的努力和成果，在重大发现具有很高的翻译影响力和众多的同行， 审查出版物。诊断免疫病理学和成像（DIIC）核心将继续：1）收集， 储存、处理和分发用于转化研究组织和生物流体，而不损害患者 护理; 2）提供关于起源部位和世界卫生组织的良好特征的肿瘤 组织学亚型和分化; 3）提供除肿瘤外正常对照组织; 4）处理和 储存组织以满足所有研究者的要求; 5）从相关患者中采集匹配的血液 6）及时提供样本; 7）提供明确的机制， 优先向计划项目调查人员分配所需资源。