Core 1: Diagnostic Immunopathology and Imaging Core

核心 1：诊断免疫病理学和成像核心

• 批准号: 10251174
• 负责人: Peter M Sadow
• 金额: $ 16.65万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-19 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10251174
• 关键词: Address; Aerodigestive Tract; Biological; Blood; Cells; Combination immunotherapy; Communities; Diagnostic; Ear; Ensure; Eye; General Hospitals; Goals; Guidelines; Head and Neck Cancer; Head and Neck Squamous Cell Carcinoma; Head and neck structure; Histologic; Human; Image; Inflammatory; Larynx; Liquid substance; Massachusetts; Methodology; Neoplasms; Oral cavity; Oropharyngeal; Pathology; Patient Care; Patients; Peer Review; Process; Publications; Reaction; Research; Research Personnel; Resources; Site; Specimen; Time; Tissues; Translational Research; Tumor-Infiltrating Lymphocytes; Work; World Health Organization; clinical care; clinically relevant; design; human tissue; immune resistance; immunopathology; innovation; neoplastic; novel; programs; sample collection; success; translational impact; tumor

ABSTRACT - DIAGNOSTIC IMMUNOPATHOLOGY AND IMAGING CORE A concerted effort to collect and bank well-characterized high-quality human tissues from the upper aerodigestive tract, including oral cavity, larynx, and oropharynx, has been an ongoing goal by Pathology at the MGH and MEE since 1990. Over time, specimen collection has evolved to more specific targeting of tissues and biologic fluids. Furthermore, the focus is shifting to the stromal component and especially the host inflammatory reaction including tumor infiltrating lymphocytes. The overall availability of these human tissues and cells has contributed to the work of many of the investigators participating in head and neck research efforts and resulting over the years in significant discoveries with high translational impact and numerous peer- reviewed publications. The Diagnostic Immunopathology and Imaging (DIIC) Core will continue to: 1) collect, store, process and distribute tissues and biologic fluids for translational research without compromise of patient care; 2) provide well-characterized tumors with respect to site of origin and World Health Organization histologic subtype and differentiation; 3) provide normal control tissue in addition to neoplasms; 4) process and store tissues to address the requirements of all investigators; 5) collect matched blood from pertinent patients for core projects; 6) provide the specimens in a timely fashion; and 7) provide well-defined mechanisms for prioritization of the distribution of requested resources to the Program Project investigators.

诊断性免疫病理与影像学核心