RTI CHEAR Exposure Assessment Hub

RTI CEAR 暴露评估中心

• 批准号: 9351595
• 负责人: TIMOTHY RAYMOND FENNELL
• 金额: $ 59.99万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9351595
• 关键词: Biochemical; Biological; Biological Markers; Budgets; CCL17 gene; California; Child; Child health care; Client; Clinical Investigator; Clinical Research; Cohort Studies; Collaborations; Comet Assay; Complex; Contracts; DNA Methylation; DNA Repair; Data Analyses; Databases; Deposition; Development; Disease; Ensure; Environment; Environmental Exposure; Epidemiologic Studies; Epidemiology; Epigenetic Process; Evaluation; Feasibility Studies; Funding; Gene Expression; Goals; Health; International; Label; Laboratories; Link; Mass Spectrum Analysis; Measurement; Messenger RNA; Methods; MicroRNAs; Molecular Analysis; Molecular Profiling; Nuclear Magnetic Resonance; Pilot Projects; Recording of previous events; Research; Research Design; Research Infrastructure; Research Training; Resources; Science; Services; System; Technology; TimeLine; Training and Education; United States National Institutes of Health; Universities; Work; clinical investigation; data sharing; design; exosome; experience; innovation; meetings; metabolomics; metabolomics resource; method development; outreach; programs; response; sample collection; web site; working group

 DESCRIPTION (provided by applicant): This application is prepared in response to RFA-ES-15-009: Children's Health Exposure Analysis Resource (CHEAR): National Exposure Assessment Laboratory Network (U2C), and, if funded, will be one of several CHEAR Hubs designed to provide exposure assessment marker measurements and biological response indicator measurements to epidemiological and clinical investigators. The ultimate goal of the RTI International CHEAR Hub is to develop a self-sustaining Hub that will maintain and develop state-of-the- art standardized methods and promote research, training, and education in assessment of exposure and response. The RTI CHEAR Hub will work within the CHEAR Network and with other CHEAR Hubs, the CHEAR Data Repository and Analysis Science Center (DRASC), and the CHEAR Coordinating Center (CC) to develop new methods; to refine existing methods to lower concentrations and new matrices; to provide guidance on study design, sample collection, and storage; and to provide services for targeted, untargeted, and biological response measurements. This proposal provides a description of the capabilities, experiences, and approaches that will be used in the Targeted Analysis Resource Core (TARC, Leader Keith Levine), the Untargeted Analysis Resource Core (UARC, Leader Susan Sumner), and the Biological Response Indicator Core (BRIC, Co-Leaders Robert Clark and Leslie Recio). Refinement of existing methods and the development of new analytical and biological approaches to assess the impact of environmental exposure will be conducted by the Development Core (DC, Leader Timothy Fennell). The Administrative Core will provide oversight for interactions with the CHEAR Program and will ensure that timelines, budgets, and staffing are appropriate for the studies to be performed. RTI has decades of experience in exposure assessment and has a history of conducting research in children's health. The RTI CHEAR Hub, directed by Dr. Timothy Fennell, is strengthened by the untargeted analysis capabilities of the NIH Eastern Regional Comprehensive Metabolomics Resource Core (RTI RCMRC, directed by Dr. Susan Sumner) and our partnership with Dr. Oliver Fiehn who directs the West Coast RCMRC at University of California at Davis and is experienced in conducting metabolomics for large cohort studies. Our partners at Integrated Laboratory Systems (Directed by Dr. Leslie Recio) bring additional in-depth strengths for the measurement of biological response indicators. The overall goal of the CHEAR Program will be to provide resources and services for use in epidemiological and clinical investigations to enable analysis of a wide range of biospecimens using state-of-the-art technologies to understand the influence of the environment on disease.

 说明（由申请人提供）：本申请是根据 RFA-ES-15-009 准备的：儿童健康暴露分析资源 (CHEAR)：国家暴露评估实验室网络 (U2C)，如果获得资助，将成为旨在向流行病学和临床研究人员提供暴露评估标记测量和生物反应指标测量的多个 CEAR 中心之一。 RTI 国际 CEAR 中心的最终目标是开发一个自我维持的中心，该中心将维护和开发最先进的标准化方法，并促进暴露和反应评估方面的研究、培训和教育。 RTI CEAR 中心将在 CEAR 网络内并与其他 CEAR 中心、CEAR 数据存储库和分析科学中心 (DRASC) 以及 CEAR 协调中心 (CC) 合作，开发新方法；改进现有方法以降低浓度和新基质；提供研究设计、样本收集和储存方面的指导；并为有针对性、无针对性和生物反应测量提供服务。该提案描述了将在目标分析资源核心（TARC，领导者 Keith Levine）、非目标分析资源核心（UARC，领导者 Susan Sumner）和生物反应指标核心（BRIC，共同领导者 Robert Clark 和 Leslie Recio）中使用的能力、经验和方法。发展核心（DC，领导人 Timothy Fennell）将改进现有方法并开发新的分析和生物方法来评估环境暴露的影响。行政核心将为与 CEAR 计划的互动提供监督，并确保时间表、预算和人员配备适合要进行的研究。 RTI 在暴露评估方面拥有数十年的经验，并且拥有开展儿童健康研究的历史。 RTI CHEAR 中心由 Timothy Fennell 博士领导，通过 NIH 东区综合代谢组学资源核心（RTI RCMRC，由 Susan Sumner 博士领导）的非针对性分析能力以及我们与加州大学戴维斯分校西海岸 RCMRC 领导者 Oliver Fiehn 博士的合作关系得到加强，Oliver Fiehn 博士在开展大型队列代谢组学方面拥有丰富的经验 研究。我们在集成实验室系统（由 Leslie Recio 博士领导）的合作伙伴为生物反应指标的测量带来了额外的深入优势。 CEAR 计划的总体目标是提供用于流行病学和临床调查的资源和服务，以便利用最先进的技术分析各种生物样本，以了解环境对疾病的影响。