RTI CHEAR Exposure Assessment Hub

RTI CEAR 暴露评估中心

• 批准号: 9351595
• 负责人: TIMOTHY RAYMOND FENNELL
• 金额: $ 59.99万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9351595
• 关键词: Biochemical; Biological; Biological Markers; Budgets; CCL17 gene; California; Child; Child health care; Client; Clinical Investigator; Clinical Research; Cohort Studies; Collaborations; Comet Assay; Complex; Contracts; DNA Methylation; DNA Repair; Data Analyses; Databases; Deposition; Development; Disease; Ensure; Environment; Environmental Exposure; Epidemiologic Studies; Epidemiology; Epigenetic Process; Evaluation; Feasibility Studies; Funding; Gene Expression; Goals; Health; International; Label; Laboratories; Link; Mass Spectrum Analysis; Measurement; Messenger RNA; Methods; MicroRNAs; Molecular Analysis; Molecular Profiling; Nuclear Magnetic Resonance; Pilot Projects; Recording of previous events; Research; Research Design; Research Infrastructure; Research Training; Resources; Science; Services; System; Technology; TimeLine; Training and Education; United States National Institutes of Health; Universities; Work; clinical investigation; data sharing; design; exosome; experience; innovation; meetings; metabolomics; metabolomics resource; method development; outreach; programs; response; sample collection; web site; working group

 DESCRIPTION (provided by applicant): This application is prepared in response to RFA-ES-15-009: Children's Health Exposure Analysis Resource (CHEAR): National Exposure Assessment Laboratory Network (U2C), and, if funded, will be one of several CHEAR Hubs designed to provide exposure assessment marker measurements and biological response indicator measurements to epidemiological and clinical investigators. The ultimate goal of the RTI International CHEAR Hub is to develop a self-sustaining Hub that will maintain and develop state-of-the- art standardized methods and promote research, training, and education in assessment of exposure and response. The RTI CHEAR Hub will work within the CHEAR Network and with other CHEAR Hubs, the CHEAR Data Repository and Analysis Science Center (DRASC), and the CHEAR Coordinating Center (CC) to develop new methods; to refine existing methods to lower concentrations and new matrices; to provide guidance on study design, sample collection, and storage; and to provide services for targeted, untargeted, and biological response measurements. This proposal provides a description of the capabilities, experiences, and approaches that will be used in the Targeted Analysis Resource Core (TARC, Leader Keith Levine), the Untargeted Analysis Resource Core (UARC, Leader Susan Sumner), and the Biological Response Indicator Core (BRIC, Co-Leaders Robert Clark and Leslie Recio). Refinement of existing methods and the development of new analytical and biological approaches to assess the impact of environmental exposure will be conducted by the Development Core (DC, Leader Timothy Fennell). The Administrative Core will provide oversight for interactions with the CHEAR Program and will ensure that timelines, budgets, and staffing are appropriate for the studies to be performed. RTI has decades of experience in exposure assessment and has a history of conducting research in children's health. The RTI CHEAR Hub, directed by Dr. Timothy Fennell, is strengthened by the untargeted analysis capabilities of the NIH Eastern Regional Comprehensive Metabolomics Resource Core (RTI RCMRC, directed by Dr. Susan Sumner) and our partnership with Dr. Oliver Fiehn who directs the West Coast RCMRC at University of California at Davis and is experienced in conducting metabolomics for large cohort studies. Our partners at Integrated Laboratory Systems (Directed by Dr. Leslie Recio) bring additional in-depth strengths for the measurement of biological response indicators. The overall goal of the CHEAR Program will be to provide resources and services for use in epidemiological and clinical investigations to enable analysis of a wide range of biospecimens using state-of-the-art technologies to understand the influence of the environment on disease.

 描述（由应用程序提供）：根据RFA-ES-15-009：儿童健康暴露分析资源（CHEAR）准备此应用程序：国家暴露评估实验室网络（U2C），如果资助，将是旨在提供旨在提供暴露枢纽的几个Chear Hub，旨在提供暴露评估评估标记测量值测量和生物学响应测量指标，以测量和生物学测量指标对流行病学研究员和诊所研究员。 RTI国际Chear枢纽的最终目标是开发一个自我维持的枢纽，该枢纽将维护和开发最先进的标准化方法，并促进研究，培训和教育，以评估暴露和反应。 RTI Chear Hub将在Chear网络和其他Chear枢纽，Chear数据存储库和分析科学中心（DRASC）以及Chear协调中心（CC）中使用，以开发新方法；将现有方法完善降低浓度和新物质的方法；提供有关研究设计，样本收集和存储的指导；并为有针对性，不靶向和生物学反应测量的服务提供服务。该提案提供了针对性分析资源核心（TARC，领导者基思·莱文），未靶向的分析资源核心（UARC，领导者Susan Sumner）和生物学响应指标（Bric，Co-Leaders，Co-Leaders Robert Clark和Leslie Recio）的能力，经验和方法的描述。对现有方法的完善以及开发新的分析和生物学方法来评估环境暴露的影响，将由开发核心（DC，领导者蒂莫西·芬内尔（Timothy Fennell））进行。行政核心将为与Chear计划的互动提供监督，并确保时间表，预算和人员配备适合进行研究。 RTI在接触评估方面拥有数十年的经验，并具有在儿童健康方面进行研究的历史。由蒂莫西·芬内尔（Timothy Fennell）博士执导的RTI Chear Hub通过NIH东部地区全面的全面代谢组合资源核心（RTI RCMRC）的不可限制的分析能力（由Susan Sumner博士执导）以及我们与我们与Oliver Fiehn博士的合作伙伴关系，并指导西海岸RCMRC和IS CORMORS的合作伙伴关系，从而加强了RTI Chear Hub。研究。我们在综合实验室系统（由Leslie Recio指导）的合作伙伴为测量生物响应指标带来了更多的深入优势。 Chear计划的总体目标是提供用于流行病学和临床研究的资源和服务，以使用最先进的技术来分析广泛的生物测量，以了解环境对疾病的影响。