RTI CHEAR Exposure Assessment Hub

RTI CEAR 暴露评估中心

• 批准号: 9776750
• 负责人: TIMOTHY RAYMOND FENNELL
• 金额: $ 99.61万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-30 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9776750
• 关键词: Biochemical; Biological; Biological Markers; Budgets; CCL17 gene; California; Child; Child Health; Client; Clinical Investigator; Clinical Research; Cohort Studies; Collaborations; Comet Assay; Complex; Contracts; DNA Methylation; DNA Repair; DNA analysis; Data Analyses; Deposition; Development; Disease; Ensure; Environment; Environmental Exposure; Environmental Impact; Epidemiology; Epigenetic Process; Evaluation; Expression Profiling; Feasibility Studies; Funding; Gene Expression; Goals; Health; International; Isotope Labeling; Laboratories; Link; Mass Spectrum Analysis; Measurement; Messenger RNA; Methods; MicroRNAs; Molecular Analysis; Nuclear Magnetic Resonance; Pilot Projects; Recording of previous events; Research; Research Design; Research Infrastructure; Research Training; Resources; Science; Services; Standardization; System; Technology; Time; TimeLine; Training and Education; United States National Institutes of Health; Universities; Work; clinical investigation; data resource; data sharing; data warehouse; design; epidemiology study; exosome; experience; innovation; metabolomics; metabolomics resource; method development; outreach; programs; public health relevance; response; sample collection; web site; working group

 DESCRIPTION (provided by applicant): This application is prepared in response to RFA-ES-15-009: Children's Health Exposure Analysis Resource (CHEAR): National Exposure Assessment Laboratory Network (U2C), and, if funded, will be one of several CHEAR Hubs designed to provide exposure assessment marker measurements and biological response indicator measurements to epidemiological and clinical investigators. The ultimate goal of the RTI International CHEAR Hub is to develop a self-sustaining Hub that will maintain and develop state-of-the- art standardized methods and promote research, training, and education in assessment of exposure and response. The RTI CHEAR Hub will work within the CHEAR Network and with other CHEAR Hubs, the CHEAR Data Repository and Analysis Science Center (DRASC), and the CHEAR Coordinating Center (CC) to develop new methods; to refine existing methods to lower concentrations and new matrices; to provide guidance on study design, sample collection, and storage; and to provide services for targeted, untargeted, and biological response measurements. This proposal provides a description of the capabilities, experiences, and approaches that will be used in the Targeted Analysis Resource Core (TARC, Leader Keith Levine), the Untargeted Analysis Resource Core (UARC, Leader Susan Sumner), and the Biological Response Indicator Core (BRIC, Co-Leaders Robert Clark and Leslie Recio). Refinement of existing methods and the development of new analytical and biological approaches to assess the impact of environmental exposure will be conducted by the Development Core (DC, Leader Timothy Fennell). The Administrative Core will provide oversight for interactions with the CHEAR Program and will ensure that timelines, budgets, and staffing are appropriate for the studies to be performed. RTI has decades of experience in exposure assessment and has a history of conducting research in children's health. The RTI CHEAR Hub, directed by Dr. Timothy Fennell, is strengthened by the untargeted analysis capabilities of the NIH Eastern Regional Comprehensive Metabolomics Resource Core (RTI RCMRC, directed by Dr. Susan Sumner) and our partnership with Dr. Oliver Fiehn who directs the West Coast RCMRC at University of California at Davis and is experienced in conducting metabolomics for large cohort studies. Our partners at Integrated Laboratory Systems (Directed by Dr. Leslie Recio) bring additional in-depth strengths for the measurement of biological response indicators. The overall goal of the CHEAR Program will be to provide resources and services for use in epidemiological and clinical investigations to enable analysis of a wide range of biospecimens using state-of-the-art technologies to understand the influence of the environment on disease.

 描述（由申请人提供）：本申请是根据RFA-ES-15-009：儿童健康暴露分析资源（CHEARS）：国家暴露评估实验室网络（U2 C）编写的，如果获得资助，将成为几个CHEARS中心之一，旨在为流行病学和临床研究人员提供暴露评估标志物测量和生物反应指标测量。RTI International CHEMICAL Hub的最终目标是发展一个自我维持的中心，该中心将维护和开发最先进的标准化方法，并促进暴露和反应评估方面的研究，培训和教育。RTI CHEMICAL Hub将在CHEMICAL Network内与其他CHEMICAL Hub、CHEMICAL Data Repository and Analysis Science Center（DRASC）和CHEMICAL Coordinating Center（CC）合作，开发新方法;改进现有方法以降低浓度和新基质;为研究设计、样本收集和储存提供指导;并为靶向、非靶向和生物反应测量提供服务。本提案描述了将用于靶向分析资源核心（TARC，领导人基思莱文）、非靶向分析资源核心（UARC，领导人苏珊萨姆纳）和生物反应指标核心（金砖四国，共同领导人罗伯特克拉克和莱斯利Recio）的能力、经验和方法。现有方法的完善和新的分析和生物方法的开发，以评估环境暴露的影响将由开发核心（DC，负责人蒂莫西芬内尔）进行。管理核心将监督与CHEMICAL项目的互动，并确保时间表、预算和人员配备适合于待开展的研究。RTI在暴露评估方面有数十年的经验，并有进行儿童健康研究的历史。由Timothy Fennell博士指导的RTI CHEMICAL Hub得到了NIH东部区域综合代谢组学资源核心（RTI RCMRC，由Susan Sumner博士指导）的非靶向分析能力以及我们与奥利弗·菲恩博士的合作关系的加强，他在加州大学戴维斯分校指导西海岸RCMRC，并在进行大型队列研究的代谢组学方面经验丰富。我们在综合实验室系统（由Leslie Recio博士指导）的合作伙伴为生物反应指标的测量带来了额外的深度优势。CHEMICAL计划的总体目标是提供用于流行病学和临床调查的资源和服务，以便使用最先进的技术分析各种生物标本，了解环境对疾病的影响。