Development of a Web-Based Group Intervention to Support Ovarian Cancer Survivors

 描述(申请人提供)：卵巢癌是第二常见的妇科癌症；然而，每年死于卵巢癌的妇女比死于所有其他妇科肿瘤的总和还要多。卵巢癌幸存者通常会经历高度的痛苦、睡眠障碍、疲劳、神经病变、多种症状和副作用，以及对生存的担忧，以及普遍较差的预后。此外，我们还记录了与卵巢癌疾病进展相关的心理社会因素和生理途径之间的密切联系。由于这些患者的生活质量(QOL)的许多方面都有妥协，加上大多数患者的存活率较低，因此开发提高QOL的创新方法至关重要，但考察心理社会干预对卵巢癌幸存者的潜在疗效的研究一直非常有限。面对面干预发展的障碍包括卵巢癌幸存者在任何一个地点的人口较少，以及患者的虚弱。根据来自卵巢癌幸存者的焦点访谈反馈，我们一直在开发针对卵巢癌幸存者的干预措施，借鉴了认知行为压力管理(CBSM)和基于正念的压力减轻(MBSR)的关键元素，以及接受和承诺治疗(ACT)的一些基于价值的内容。在过去的一年里，我们开发了一个移动响应网络平台，以提供基于网络的实时会议心理社会干预，卵巢癌患者可以在家里访问。该应用程序的主要目标是进一步开发、Web部署、现场可用性和现场 在卵巢癌幸存者中测试这种干预措施。这项研究计划的最终目标将是利用网络进行一项更大规模的随机临床试验。 分娩，检查情绪、症状和生活质量，以及临床相关的终点和生物标志物。应用程序的意义在于，这种干预具有潜在的 改善卵巢癌幸存者的生活质量，并可能有能力延长无复发生存期。

 DESCRIPTION (provided by applicant): Ovarian cancer is the second most common gynecologic cancer; however, more women die annually from ovarian cancer than from cancers of all other gynecologic sites combined. Ovarian cancer survivors often experience high levels of distress, sleep disturbances, fatigue, neuropathies, multiple symptoms and side effects, and existential concerns, along with a generally poor prognosis. Additionally, we have documented strong links between psychosocial factors and physiological pathways related to disease progression in ovarian cancer. Because of compromises to many aspects of quality of life (QOL) combined with low rates of survival for the majority of these patients, development of innovative approaches for improving QOL is of paramount importance, but research examining the potential efficacy of psychosocial interventions in ovarian cancer survivors has been extremely limited. Barriers to development of an in-person intervention have included low populations of ovarian cancer survivors at any one site and debility of patients. Based on focus interview feedback from ovarian cancer survivors, we have been developing an intervention targeted to ovarian cancer survivors, drawing from key elements of Cognitive Behavioral Stress Management (CBSM) and Mindfulness-Based Stress Reduction (MBSR) along with some of the value-based content of Acceptance and Commitment Therapy (ACT). Over the last year we have developed a mobile responsive web platform to deliver a live web-based conferencing psychosocial intervention that ovarian cancer patients can access from their homes. The primary goal of this application is further development, web deployment, field usability, and field testing of this intervention among ovarian cancer survivors. The ultimate goal of this program of research will be to conduct a larger scale randomized clinical trial of this intervention using web delivery, with examination of mood, symptoms, and QOL along with clinically relevant endpoints and biomarkers. The significance of the application is that this intervention has the potential to improve quality of life of ovarian cancer survivors and may have the ability to lengthen the period of recurrence free survival.