Evaluating the Head's Response to Impulsive Forces in Young Athletes

评估年轻运动员头部对冲动力的反应

• 批准号: 9094275
• 负责人: James Travis Eckner
• 金额: $ 13.21万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-15 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9094275
• 关键词: Acceleration; Address; Age; Anatomy; Area; Award; Biomechanics; Brain; Brain Concussion; Cervical; Characteristics; Child; Clinical; Clinical Oncology Supplement (K12); Clinical Research; Complex; Computer Simulation; Development Plans; Devices; Educational Status; Event; Female; Flexor; Funding; Future; Gender; Goals; Head; Head Movements; Head and neck structure; Health; Human; Individual; Inferior; Injury; Investigation; K-Series Research Career Programs; Laboratories; Lateral; Location; Measurable; Measurement; Measures; Mechanics; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Motion; Muscle; Musculoskeletal; Neck; Neurons; Outcome; Pattern; Physiatrist; Physical Medicine; Physical Rehabilitation; Positioning Attribute; Preventive; Protocols documentation; Research; Research Design; Research Support; Risk; Risk Factors; Role; Rotation; Skeletal muscle structure of neck; Speed; Sports; Statistical Data Interpretation; System; Techniques; Testing; Training; Ultrasonography; United States National Institutes of Health; Violence; Whiplash Injuries; Work; base; biomechanical engineering; biomechanical model; brain tissue; career; career development; clinically significant; design; disability; elastography; experience; head impact; high risk; human subject; improved; in vivo; kinematics; male; mild traumatic brain injury; muscle strength; novel; prediction algorithm; programs; response; skills; vector

DESCRIPTION (provided by applicant): Sport-related concussion occurs when linear and angular head motion caused by external physical forces disrupts an athlete's brain function at the neuronal level. Athletes with smaller, weaker necks, including child and female athletes, are thought to be at increased risk of concussion because their necks are less able to counter these externally acting forces resulting in more violent head movement patterns. The bi-directional whiplash motion that occurs when an athlete's head rapidly changes its direction of rotation may also increase the risk of concussion associated with an individual impact, as compared to a uni-directional rotation pattern of similar magnitude. The proposed biomechanical investigation will pursue the following specific aims: AIM 1) to determine the relationship between sonographic measures of cervical muscle size and stiffness and the head's kinematic response under a standardized impulsive force in each anatomical plane across the spectra of age and gender; AIM 2) to determine whether in vivo commercial impact sensing systems can predict bi-directional versus uni-directional rotation patterns, as determined by a high speed kinematic motion capture system, during a sport-simulated bracing task. The working hypotheses associated with these aims are: H1) the magnitudes of the head's linear and angular velocity changes will be negatively associated with cervical muscle size and stiffness and will be more strongly correlated with these sonographic measures than concurrently measured neck strength in each plane (AIM 1); H2) resultant impact vectors generated by commercial impact sensing systems that are located inferior of the head's center of mass will be associated with bi-directional head rotation patterns, while impact vector locations superior to the head's center of mass will be associated with uni-directional rotation (AIM 2). The Candidate has a clinical background in Physical Medicine and Rehabilitation with expertise in mild traumatic brain injury, specifically sport-related concussion. He has master's level training in clinical research design and statistical analysis as well as additional basic training and experience in biomechanical engineering principles and laboratory techniques. He is committed to a career in sport concussion research focusing on injury biomechanics and he plans to use the additional training he receives through this NIH Career Development Award to support his future work in this field. The Candidate and his mentoring team have designed a career development plan to accomplish three training goals: 1) become proficient in biomechanical modeling techniques to permit effective use and interpretation of basic biomechanical models of the human head and neck, 2) obtain expertise in musculoskeletal ultrasonography, allowing for proficient measurement of cervical muscle size (cross sectional area) and stiffness (elastography), 3) improve grantsmanship skills to facilitate ongoing research support.

描述（由申请人提供）：当外部物理力引起的线性和角度头部运动在神经元水平上破坏运动员的大脑功能时，发生运动相关脑震荡。颈部较小、较弱的运动员，包括儿童和女性运动员，被认为患脑震荡的风险更高，因为他们的颈部不太能够对抗这些外部作用力，导致头部运动模式更暴力。与类似大小的单向旋转模式相比，当运动员的头部快速改变其旋转方向时发生的双向挥鞭式运动也可能增加与个体撞击相关联的脑震荡的风险。提出的生物力学研究将追求以下具体目标：目的1）确定超声测量的颈部肌肉大小和刚度与头部在每个解剖平面的标准化冲击力下的运动学响应之间的关系，跨越年龄和性别谱;目的2）确定体内商业撞击感测系统是否可以预测双向与单向旋转模式，如在运动模拟支撑任务期间由高速运动学运动捕捉系统确定的。与这些目标相关的工作假设是：H1）头部的线速度和角速度变化的幅度将与颈部肌肉的大小和刚度负相关，并且与这些超声测量值的相关性将比在每个平面上同时测量的颈部强度更强（AIM 1）; H2）由位于头部质心下方的商用撞击感测系统生成的合成撞击矢量将与双向头部旋转模式相关联，而高于头部质心的撞击矢量位置上级将与单向旋转（AIM 2）相关联。候选人具有物理医学和康复方面的临床背景，擅长轻度创伤性脑损伤，特别是运动相关脑震荡。他拥有临床研究设计和统计分析方面的硕士水平培训，以及生物力学工程原理和实验室技术方面的额外基础培训和经验。他致力于运动脑震荡研究的职业生涯，重点是损伤生物力学，他计划使用他通过这个NIH职业发展奖获得的额外培训来支持他未来在这一领域的工作。候选人及其指导团队设计了职业发展计划，以实现三个培训目标：1）精通生物力学建模技术，以有效使用和解释人体头颈部的基本生物力学模型，2）获得肌肉骨骼超声检查的专业知识，以熟练测量颈部肌肉的大小（横截面积）和刚度（弹性成像），3）提高花岗岩技能，以促进正在进行的研究支持。

项目成果

A Clinical Approach to the Diagnosis of Traumatic Encephalopathy Syndrome: A Review.

诊断创伤性脑病综合征的临床方法：评论。

• DOI: 10.1001/jamaneurol.2015.5015
• 发表时间: 2016-06-01
• 期刊: JAMA neurology
• 影响因子: 29
• 作者: Reams N;Eckner JT;Almeida AA;Aagesen AL;Giordani B;Paulson H;Lorincz MT;Kutcher JS
• 通讯作者: Kutcher JS

Is Migraine Headache Associated With Concussion in Athletes? A Case-Control Study.

• DOI: 10.1097/jsm.0000000000000346
• 发表时间: 2017-05
• 期刊: Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine
• 作者: Eckner JT;Seifert T;Pescovitz A;Zeiger M;Kutcher JS
• 通讯作者: Kutcher JS