6th ASM Conference on Cell-Cell Communication in Bacteria

项目总结 细菌的定义是单细胞有机体，但它们像其他形式的生命一样，已经进化 令人惊讶的协调行为的复杂方法。过去25年的研究表明 揭示了广泛的细菌可以通过不同的机制进行交流。在大多数情况下 这些微生物对话是通过可扩散信号的交换进行的，尽管有 也是依靠接触进行沟通的明显例子。许多微生物利用这些 监测和响应人口密度的信号机制，这是一个经常描述的过程 作为法定人数感应。这项研究的大部分都集中在单一物种的交流上，但 日益增长的研究领域是多个物种之间更复杂的交流行为 指细菌或细菌和其他真核生物。细菌间的交流不是 然而，仅限于法定人数感应机制，并且有越来越多的证据表明 信令可以在一系列不同的容量下运行。这一沟通具有深远的意义 对我们理解病原体和共生菌如何调节关键因素的影响 用于彼此之间和它们的东道主之间的互动。此应用程序请求为 第六届美国微生物学会主办的细胞-细胞会议 细菌交流，将于2017年10月16日至19日在佐治亚州雅典举行。确实有 CCCB会议的两个主要目标。第一个是让会议成为一个平台， 促进和吸引参与细菌研究的年轻和种族多元化的研究人员 传播研究。年轻和多样化的研究人员将被选为这次会议的演讲者 会议和辅导午餐将为学生提供探索 细菌传播领域职业选择的多样性。这方面的第二个目标 会议的目的是促进具有不同专业知识的研究人员之间的互动。因此，很小 将创建研究人员小组，在午餐时间坐在一起，每个成员 来自一个不同的研究领域：结构生物学，计算 生物学、合成生物学、化学、细菌分子遗传学、微生物生态学和 微生物致病机制。在这些小组中，科学家们将讨论他们最紧迫的问题 细菌通信的研究挑战，目标是创造新的解决方案， 研究想法，甚至未来的合作。

PROJECT SUMARY Bacteria by definition are single-celled organisms, but they, like other forms of life, have evolved surprising complex methods to coordinated behaviors. Research over the past 25 years has revealed that a wide range of bacteria can communicate by diverse mechanisms. In most cases these microbial conversations occur through the exchange of diffusible signals, although there are also clear examples of contact-dependent communication. Many microbes use these signaling mechanisms to monitor and respond to population density, a process often described as quorum sensing. Much of this research has focused on single species communication, but a growing reseach area is the more complex behavior of communication between multiple species of bacteria or bacteria and other eukaryotic organisms. Interbacterial communication is not however restricted to quorum sensing mechanisms and there is mounting evidence that signaling can function in a range of different capacities. This communication has profound impacts on our understanding of how pathogens and commensals often regulate factors critical for interaction with each other and their hosts. This application requests financial support for the sixth American Society for Microbiology-sponsored conference on Cell-cell Communication in Bacteria, to be held from October 16 – 19, 2017, in Athens, GA. There are two main goals of the CCCB conference. The first is to have the meeting serve as a platform to promote and attract young and ethnically diverse investigators involved in bacterial communication research. Young and diverse researchers will be chosen to be speakers at this conference, and a mentoring lunch will provide students with the opportunity to explore the diversity of career options in the bacterial communication field. The second goal of this conference is to foster interactions between reseachers with diverse expertise. Thus, small groups of researchers will be created that are seated together during lunch, with each member of the group coming from from a different research area: structural biology, computational biology, synthetic biology, chemistry, bacterial molecular genetics, microbial ecology, and microbial pathogenesis. In these small groups scientists will discuss their most pressing research challenges in bacterial communication with the goal of creating new solutions, research ideas, and even future collaborations.