Mobile Phone-Based Alcohol Response Assessment in Young Adult Heavy Drinkers - Resubmission 01

项目总结摘要 实验室酒精挑战，研究人员评估参与者对注射酒精的反应 一种受控的环境，为酒精研究界提供了关于 个体对酒精的反应与饮酒相关问题的风险之间的联系。在最近的研究中 在年轻的成年酗酒者中，我们的研究小组表明，他们对酒精的刺激性和奖励性更敏感 对酒精使用障碍(AUD)症状未来发展的预测作用比更低 对镇静或醉人效果的反应。尽管实验室衍生酒精的挑战仍然是“黄金” 作为测量酒精反应的标准，这种方法的时间和资源密集型性质 阻碍了将酒精挑战研究结果扩展到干预和流行病学研究的努力。 这个问题的一个潜在解决方案是开发和验证一种可访问且用户友好的方法来 使用生态瞬时评估(EMA)在实验室外测量酒精反应。EMA 方法实时评估个体在自然环境中的行为和经历。快速 移动智能手机技术的进步和这些设备的高采用率(86%的年轻人 拥有一部智能手机)建议EMA酒精反应数据可以通过这种便携式和用户收集- 友好的方法，例如，通过短信和移动网络从自己的智能手机提供数据。我们的前- 试点工作表明，使用智能手机测量体内的酒精反应是可靠、安全和良好的- 年轻的成年酗酒者所接受的。这项提案的目标是在此基础上进一步建立 基于智能手机的EMA技术测量酒精反应的可靠性、有效性和安全性 饮酒者的自然环境，并检查与通过实验室获得的相同测量结果的相关性 酒精挑战。我们计划收集至少两次真实饮酒过程中的酒精反应数据 对21-29岁的青少年酗酒者的调查，并将这些反应与 实验室酒精挑战赛。智能手机程序的安全性将在第二天和两周内进行评估 对酒精使用和后果的后续评估，并将这些结果与以下样本进行比较 N=20名酗酒者，他们也将完成这些措施，但不会完成智能手机/实验室评估。 估计呼气酒精含量(EBrAC)将在基于智能手机的评估和 实际的BRAC将在实验室挑战期间进行测量。基于实验室和智能手机的 评估将使用Brief评估主观酒精刺激、镇静和奖励(喜欢和想要) (~1分钟)，心理测量学良好的测量。这一结果将有助于了解个体差异。 在自然环境中的酒精反应中。如果被证明是可靠、有效和安全的，这款新智能手机- 基于EMA的技术也可用于AUD风险评估和治疗的未来研究 作为以人口为基础的工作，以检查饮酒行为和反应的变化模式。

PROJECT SUMMARY ABSTRACT Laboratory alcohol challenges, in which researchers assess participants’ responses to alcohol administered in a controlled setting, have provided the alcohol research community with important knowledge about the associations between individual responses to alcohol and risk for drinking-related problems. In recent studies in young adult heavy drinkers, our group showed that greater sensitivity to alcohol’s stimulant and rewarding effects was more predictive of future development of alcohol use disorder (AUD) symptoms than were lower responses to sedative or intoxicating effects. While laboratory-derived alcohol challenges remain the “gold standard” for measuring alcohol responses, the time- and resource-intensive nature of this approach has hampered efforts to extend findings of alcohol challenge studies to intervention and epidemiological research. One potential solution to this problem is to develop and validate an accessible and user-friendly method to measure alcohol responses outside of the laboratory using ecological momentary assessment (EMA). EMA methods assess individuals’ behaviors and experiences in real-time and in their natural environment. Rapid advances in mobile smartphone technology and high adoption rates of these devices (86% of young adults own a smartphone) suggest that EMA alcohol response data may be collected via this portable and user- friendly method, e.g., providing data via text messaging and mobile web from one’s own smartphone. Our pre- pilot work suggests that using smartphones to measure alcohol responses in vivo is reliable, safe, and well- received by young adult heavy drinkers. The goal of this proposal is to build on this to further establish the reliability, validity, and safety of a smartphone-based EMA technique for measuring alcohol responses in drinkers’ natural environments, and to examine associations with identical measures obtained via laboratory alcohol challenge. We plan to collect alcohol response data during at least 2 real-world drinking episodes from 64 young adult heavy drinkers (ages 21-29), and compare these responses with those obtained during a laboratory alcohol challenge. Safety of the smartphone procedure will be assessed by next-day and 2-week follow-up assessments of alcohol use and consequences, and by comparing those outcomes to a sample of n=20 heavy drinkers who will also complete these measures but not the smartphone/laboratory assessments. Estimated breath alcohol content (eBrAC) will be calculated during the smartphone-based assessments and actual BrAC will be measured during the laboratory challenge. Both the laboratory- and smartphone-based assessments will assess subjective alcohol stimulation, sedation, and reward (liking and wanting) using brief (~1 min), psychometrically sound measures. The results will contribute to knowledge on individual differences in alcohol responses in the natural environment. If shown to be reliable, valid, and safe, this new smartphone- based EMA technique could be used to inform future research on AUD risk assessment and treatment, as well as population-based work to examine changing patterns of drinking behavior and responses.