Natural environment assessment of alcohol responses in risky drinkers

危险饮酒者酒精反应的自然环境评估

• 批准号: 10611483
• 负责人: DANIEL J FRIDBERG
• 金额: $ 19.75万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-20 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10611483
• 关键词: Abstinence; Acute; Address; Adherence; Adult; Age; Alcohol abuse; Alcohol consumption; Alcohols; Anxiety; Beverages; Biosensor; Cellular Phone; Consumption; Data; Development; Dropout; Ecological momentary assessment; Enrollment; Environment; Event; Exclusion; Exhibits; Future; Generations; Goals; Heavy Drinking; Hour; Individual; Individual Differences; Knowledge; Laboratories; Light; Measures; Methodology; Methods; Modality; Modeling; Moods; National Institute on Alcohol Abuse and Alcoholism; Negative Reinforcements; Outcome; Participant; Patient Self-Report; Pattern; Persons; Phenotype; Placebo Control; Positive Reinforcements; Reaction Time; Reporting; Research; Research Personnel; Resolution; Resources; Rewards; Risk; Risk Factors; Role; Sedation procedure; Sensitivity and Specificity; Stress; Subgroup; Surveys; Technology; Testing; Time; Training; Work; Wrist; addiction; alcohol effect; alcohol reinforcement; alcohol related consequences; alcohol research; alcohol response; alcohol use disorder; allostasis; binge drinking; clinically relevant; cost; drinking; drinking behavior; experience; improved; individual response; predictive modeling; response; sedative; self reported behavior; sensor; social; theories; user-friendly; wearable sensor technology

PROJECT SUMMARY ABSTRACT Laboratory alcohol challenges have provided important knowledge about individual responses to alcohol and risk for drinking-related problems. However, this approach is time- and resource-intensive and cannot fully capture real-world alcohol responses. Therefore, the MPI propose developmental work on a method for assessing ambulatory alcohol responses that combines smartphone-based high-resolution ecological momentary assessment (HR-EMA) with new-generation, wrist-worn alcohol biosensors (BACTrack Skyn™) to provide objective verification of alcohol use. The over-arching goal of this developmental R21 proposal is to compare HR-EMA-derived real-time responses during typical heavy drinking episodes in the natural environment in individuals across the alcohol use continuum, including alcohol use disorder (AUD) drinkers, who have largely been excluded from such research, as well as heavy social drinkers (HD) and light drinker controls (LD). The proposed research will include smartphone assessments throughout a typical drinking episode in participants’ natural environment as well during a comparison non-alcohol drinking beverage consumption episode assessed at approximately the same time but on a different day. Participants will complete brief 1-minute smartphone-based surveys at multiple time points during their drinking episodes to assess their quantity consumed, subjective responses, and contextual events. They will also complete brief daily mood surveys and next-day surveys after the drinking episodes to assess carry-over effects and consequences. The noninvasive wrist-worn sensor will be used during, and for 12 hours after, each drinking episode as objective verification of self-report behavior. The study will enroll 105 participants (35/per subgroup) between ages 21-55 for participation over an approximate one-week interval. We conservatively anticipate up to a 15% drop-out rate in order to have a final N=90 participants. Our first aim is to compare acute subjective responses during alcohol drinking episodes in the natural environment across drinker subgroups. We predict that alcohol will produce higher stimulation, liking, and wanting in AUD and HD than in LD, particularly early in the drinking episode (i.e., first hour) and greater reduction in anxiety and stress in AUD versus HD and LD, after controlling for amount consumed and non-alcohol drinking episode responses. We also predict that wearable biosensors will be acceptable (≥85% use, few losses or damage) and show good sensitivity and specificity detect alcohol use vs. non-use in >90% of episodes. Our second aim is to examine individual differences in acute alcohol responses as a function of drinking pace. We predict that faster-paced alcohol consumption will be positively associated with stimulation and wanting and inversely associated with sedation, and these effects will be most pronounced in AUD vs LD, with HD intermediate. In sum, the proposed research will advance the alcohol research field by expanding HR-EMA methodologies to assess natural environment acute drinking behavior, subjective response, and drinking-related outcomes in diverse, clinically-relevant drinker subgroups.

项目总结摘要 实验室酒精挑战提供了关于个体对酒精的反应的重要知识 与饮酒有关的问题的风险。然而，这种方法是时间和资源密集型的，不能完全 捕捉真实世界中的酒精反应。因此，MPI建议开发一种方法，以 结合基于智能手机的高分辨率生态技术评估动态酒精反应 使用新一代腕式酒精生物传感器(BACTrack Skyn™)进行瞬时评估 提供酒精使用情况的客观核实。此开发R21提案的总体目标是 比较自然人群中典型重度饮酒期间HR-EMA得出的实时反应 整个酒精使用过程中的个人环境，包括酒精使用障碍(AUD)饮酒者， 在很大程度上被排除在这类研究之外的人，以及大量社交饮酒者(HD)和少量饮酒者 控制(LD)。这项拟议的研究将包括对典型饮酒过程中的智能手机进行评估 受试者自然环境中的插曲以及在对比非酒精饮料期间的情况 在大致相同的时间评估消费事件，但在不同的日期。参与者将 在饮酒期间的多个时间点完成基于智能手机的简短1分钟调查，以 评估他们的消耗量、主观反应和背景事件。他们还将完成简短的 每日情绪调查和饮酒后第二天的调查，以评估遗留影响和 后果。这种戴在手腕上的非侵入性传感器将在每次饮酒期间和之后12小时内使用 事件作为自我报告行为的客观验证。这项研究将招募105名参与者(35人/每个小组) 年龄在21岁至55岁之间，参加时间间隔约为一周。我们保守地期待着 将辍学率提高到15%，以便最终有N=90名参与者。我们的第一个目标是比较尖锐的主观 不同饮酒者亚群在自然环境中饮酒期间的反应。我们预测 酒精会在AUD和HD中产生比LD更高的刺激性、喜好和渴望，特别是在早期 与HD和LD相比，AUD组的饮酒插曲(即第一个小时)以及焦虑和压力的更大程度减轻， 在控制了饮酒量和非饮酒量后，事件反应。我们还预测， 可穿戴生物传感器将是可接受的(≥85%的使用率，损失或损坏很少)，并显示出良好的灵敏度和 在90%的发作中，特异性检测酒精使用和不使用的情况。我们的第二个目标是检查个人 急性酒精反应的差异作为饮酒速度的函数。我们预测节奏较快的酒精 消费将与刺激和渴求正相关，与镇静负相关， 而这些影响在AUD和LD中最为明显，而HD居中。总而言之，拟议的研究 将通过扩展HR-EMA方法来评估自然环境来推进酒精研究领域 临床相关的各种急性饮酒行为、主观反应和与饮酒相关的结局 饮酒者亚群。