Cognitive Control in Anxiety: The Role of Ovarian Hormones

焦虑中的认知控制：卵巢激素的作用

• 批准号: 9249682
• 负责人: Jason Scot Moser
• 金额: $ 54.48万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-03-25 至 2021-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9249682
• 关键词: Address; Affect; Age; Animals; Anxiety; Anxiety Disorders; Behavior Control; Brain; Clinical Psychology; Collection; Communities; Comorbidity; Computers; Data; Diagnostic; Disease; Engineering; Estradiol; Female; Frequencies; Functional disorder; Glare; Goals; Healthcare; Hormones; Human; Impaired cognition; Impairment; Laboratories; Light; Longevity; Maintenance; Measurement; Measures; Menstrual cycle; Mental Health; Methods; Modeling; Monitor; Nature; Neurobiology; Neuroendocrinology; Ovarian hormone; Ovulation; Performance; Phase; Play; Progesterone; Protocols documentation; Puberty; Reporting; Research; Resources; Risk; Role; Sampling; Scientist; Sex Characteristics; Short-Term Memory; Source; Specific qualifier value; Structure; Symptoms; Techniques; Testing; Time; Translations; Woman; Women' s Health; Work; anxiety symptoms; anxious; clinical development; cognitive control; cognitive neuroscience; design; disability; health care service utilization; indexing; innovation; longitudinal design; men; neurobehavioral; neurobiological mechanism; neurophysiology; novel; pre-clinical; public health priorities; public health relevance; sex; skills; theories; tool; tool development; young adult

 DESCRIPTION (provided by applicant): The proposed project will address the nature and impact of anxiety in women by examining the interplay of anxiety, cognitive control dysfunction, and ovarian hormones (i.e., estradiol and progesterone). Despite sex differences in brain structure and function critical to cognitive control, limited works has been dedicated to directly examining how such differences might play a role in how anxiety manifests in and affects women. We will address this glaring gap in our understanding of anxiety in women by testing the novel hypothesis that estradiol "amplifies" the association between anxiety - verbal worry, in particular - and cognitive control dysfunction. The design of the study uses a community sample of young adult females assessed intensively across the menstrual cycle to directly examine the contributions of ovarian hormones to the association between worry and cognitive control dysfunction. It will leverage the power of an interdisciplinary collaborative team consisting of experts in cognitive neuroscience, neuroendocrinology, women's health, clinical psychology, and computer engineering. The proposed project will involve collecting daily measures of anxiety-related symptoms and ovarian hormones as well as neurobehavioral indices of cognitive control at four separate occasions during the menstrual cycle. The specific aims of the study are to: 1) establish the role of estradiol in the association between worry and impaired working memory, 2) confirm the role of estradiol in the association between worry and maladaptive cognitive control-related performance monitoring, and 3) delineate the role of estradiol in the interactive effect of worry and working memory on maladaptive cognitive control-related performance monitoring. The long-term promise of this research is that it will elucidate a neuroendocrinological mechanism involved in the unique nature and impact of anxiety in women. Our multi- method, mechanistic approach has the potential to pinpoint particular periods of elevated risk for anxiety- related cognitive dysfunction during the menstrual cycle and across the lifespan (e.g., puberty), as well as identify novel neurobiological treatment targets for anxiey disorders in women.

 描述（由申请人提供）：拟议项目将通过检查焦虑、认知控制功能障碍和卵巢激素（即雌二醇和黄体酮）之间的相互作用来解决女性焦虑的性质和影响。尽管大脑结构和功能上的性别差异对认知控制至关重要，但致力于直接研究这些差异如何在女性焦虑表现和影响中发挥作用的工作还很有限。我们将通过测试雌二醇“放大”焦虑（尤其是言语担忧）与认知控制功能障碍之间的关联这一新假设来解决我们对女性焦虑理解中的明显差距。该研究的设计使用了年轻成年女性的社区样本，在整个月经周期中进行了深入评估，以直接检查卵巢激素对忧虑与认知控制功能障碍之间关系的影响。它将利用由认知神经科学、神经内分泌学、女性健康、临床心理学和计算机工程专家组成的跨学科协作团队的力量。拟议的项目将涉及在月经周期的四个不同时刻收集焦虑相关症状和卵巢激素的日常测量值以及认知控制的神经行为指数。该研究的具体目的是：1）确定雌二醇在忧虑与工作记忆受损之间的关联中的作用，2）确认雌二醇在忧虑与适应不良的认知控制相关的表现监测之间的关联中的作用，以及3）描绘雌二醇在忧虑和工作记忆对适应不良的认知控制相关的表现监测的交互作用中的作用。这项研究的长期前景是，它将阐明与女性焦虑的独特性质和影响有关的神经内分泌机制。我们的多方法、机制方法有可能查明月经周期和整个生命周期（例如青春期）焦虑相关认知功能障碍风险升高的特定时期，并确定女性焦虑症的新神经生物学治疗目标。