Nano Characterization and Nano Fabrication Core

纳米表征和纳米制造核心

• 批准号: 9324948
• 负责人: Robert Sinclair
• 金额: $ 24.63万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9324948
• 关键词: Biocompatible Materials; Biological; CCNE1 gene; Cancer Center; Cells; Contrast Media; Electron Microscope; Electron energy loss spectroscopy; Equipment; Goals; Heating; In Situ; Ions; Laboratories; Liquid substance; Magnetic nanoparticles; Nanostructures; Nanotechnology; Preparation; Research; Research Personnel; Research Support; Resolution; Resources; Sampling; Scanning; Structure; System; Techniques; Titan; Training; Training Support; Transmission Electron Microscopy; Ultrasonography; cancer diagnosis; cryogenics; electron beam lithography; extracellular vesicles; nano; nanofabrication; nanomaterials; nanoparticle; operation; success; tool; translational diagnostics; transmission process

Core 1 Summary/Abstract The Nano Characterization and Nano Fabrication research core will provided advanced characterization and synthesis support for the projects within the CCNE-TD. The core consists of the Stanford Nano Shared Facilities (SNSF) which is comprised of the Stanford Nanocharacterization Laboratory (SNL) and the Stanford Nano Center (SNC) offering resources for the analysis and fabrication of nanostructures and their interactions with biological materials. The SNL and SNC host advanced characterization and fabrication equipment as well as a sophisticated staff of experts able to train and support users in the operation of this equipment. These facilities include a FEI Titan 300-80kV environmental transmission electron microscope (TEM), a high resolution FEI Magellan scanning electron microscope (SEM), a FEI Helios dual beam focused ion beam/scanning electron microscope with cryogenic capabilities (FIB/SEM) and a JEOL JBX-6300 electron beam lithography system (E- Beam) among many others. The Nano Characterization and Nano Fabrication core will utilize these facilities and their expertise in the characterization of nanostructures and their interactions with biological materials to support the research goals of all the projects associated with the CCNE-TD. This support will include the use of a liquid cell TEM sample holder to characterize the nanobubbles being generated as ultrasound and photoacoustic contrast agents in project 4. We will also be using the advanced cryo capabilities of the Helios dual beam to prepare biological TEM samples of the highest quality to locate the self-assembling nanoparticles being developed in project 1 inside of cells. The Nano Characterization and Nano Fabrication core will provide expert support to all of the projects in the CCNE-TD as well as the other CCNEs that may need advanced characterization or fabrication support.

核心1摘要/摘要 纳米表征和纳米制造研究核心将提供先进的表征和 为CCNE-TD内的项目提供综合支持。核心部分由斯坦福大学纳米共享设施组成 （SNSF），由斯坦福大学纳米表征实验室（SNL）和斯坦福大学纳米 中心（SNC）提供资源的分析和制造的纳米结构及其相互作用， 生物材料。SNL和SNC拥有先进的表征和制造设备， 能够培训和支持用户操作该设备的资深专家工作人员。这些设施 包括FEI Titan 300- 80 kV环境透射电子显微镜（TEM）、高分辨率FEI 麦哲伦扫描电子显微镜（SEM），FEI Helios双束聚焦离子束/扫描电子显微镜 具有低温能力的显微镜（FIB/SEM）和JEOL JBX-6300电子束光刻系统（E- 梁）在许多其他。纳米表征和纳米制造核心将利用这些设施 以及他们在纳米结构表征及其与生物材料相互作用方面的专业知识， 支持与CCNE-TD相关的所有项目的研究目标。这种支持将包括使用 液体池TEM样品保持器，用于表征超声产生的纳米气泡，以及 光声造影剂在项目4中。我们还将使用太阳神号先进的低温能力 双光束制备最高质量的生物TEM样品，以定位自组装纳米颗粒 在项目1的细胞内进行开发。纳米表征和纳米制造核心将提供 为CCNE-TD中的所有项目以及其他可能需要先进技术的CCNE提供专家支持 特征化或制造支持。