Understanding Complex Gene Editing Systems and RNA Biology in Oxytricha
了解尖毛虫中复杂的基因编辑系统和 RNA 生物学
基本信息
- 批准号:9276953
- 负责人:
- 金额:$ 72.92万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-07-01 至 2022-06-30
- 项目状态:已结题
- 来源:
- 关键词:AddressArchitectureBiological ModelsBiologyChromatinChromosomal RearrangementComplexDNADependenceDevelopmentDiseaseDistantEpigenetic ProcessEukaryotaEventEvolutionFrequenciesGene RearrangementGenesGeneticGenetic RecombinationGenomeGenome StabilityGenomic InstabilityGoalsHumanInheritedKnowledgeLightMaintenanceMalignant NeoplasmsMolecularMolecular GeneticsOrganismOxytrichaPathway interactionsProcessPublic HealthRNARNA BiochemistryRNA EditingRNA ProcessingRNA SplicingResearchRoleSystemTumor Suppressor GenesUntranslated RNAVariantcancer genomechimeric genechromothripsiscomparative genomicsgenome integrityhuman diseaseinsightmicrobialnoveloverexpressiontooltumor
项目摘要
Understanding Complex Gene Editing Systems and RNA Biology in Oxytricha
Project Summary/Abstract:
The PI's lab studies novel genetic systems in microbial eukaryotes, bringing a strongly molecular and
mechanistic approach to understanding genome evolution and diversity. The surprisingly sophisticated
variations on DNA and RNA processing in microbial eukaryotes display a wide range of genome architectures
and genetic systems. Some pathways erode the notions of a gene (e.g. scrambled genes and RNA editing)
and even Mendelian inheritance, reminding us that a genome sequence can be a far cry from knowledge of
its products. Genome rearrangements occur in diverse organisms, and contribute to many human diseases,
especially cancer—a disease of the genome, but the extreme level of programmed DNA rearrangements and
dependence on chromosomal rearrangements for correct development in the ciliate Oxytricha make it an
ideal model system to study genome remodeling and the roles of RNA in epigenetic control of this process.
The proposed research will focus on understanding the molecular mechanism and evolutionary origin of this
remarkable phenomenon. Goals for the next five years include obtaining a more detailed understanding of
the interactions between small and long noncoding RNAs, both with each other and together with the
rearranging genome. Tools from molecular genetics, RNA biochemistry, and chromatin biology provide the
platform for functional studies, while comparative genomics of closely and more distantly related species will
provide insight into the evolutionary origins of scrambled genomes and complex genetic architectures in the
Oxytricha lineage, addressing the basic questions of how they rearrange during development and how they
arose during evolution.
理解尖毛藻中复杂的基因编辑系统和RNA生物学
项目概要/摘要:
PI的实验室研究微生物真核生物中的新型遗传系统,带来了强烈的分子和
理解基因组进化和多样性的机械方法。令人惊讶的复杂
微生物真核生物中DNA和RNA加工的变异显示出广泛的基因组结构
基因系统。一些途径削弱了基因的概念(例如,乱序基因和RNA编辑)
甚至孟德尔遗传,提醒我们,基因组序列可以是一个遥远的知识,
其产品。基因组重排发生在不同的生物体中,并导致许多人类疾病,
尤其是癌症--一种基因组疾病,但程序化DNA重排的极端水平,
依赖于染色体重排的正确发展的纤毛尖毛类,使之成为一个
理想的模型系统来研究基因组重塑和RNA在这一过程的表观遗传控制中的作用。
拟议的研究将侧重于了解这一分子机制和进化起源,
一个非常显著的现象。未来五年的目标包括更详细地了解
小的和长的非编码RNA之间的相互作用,无论是彼此之间还是与
重组基因组来自分子遗传学、RNA生物化学和染色质生物学的工具提供了
功能研究的平台,而比较基因组学的密切和更遥远的相关物种将
提供了深入了解混乱的基因组和复杂的遗传结构的进化起源,
Oxytricha谱系,解决了它们在发育过程中如何重新排列以及它们如何
是在进化过程中产生的。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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LAURA F LANDWEBER其他文献
LAURA F LANDWEBER的其他文献
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{{ truncateString('LAURA F LANDWEBER', 18)}}的其他基金
Understanding Complex Genome Editing and RNA Biology in Oxytricha
了解尖毛虫中复杂的基因组编辑和 RNA 生物学
- 批准号:
10632000 - 财政年份:2017
- 资助金额:
$ 72.92万 - 项目类别:
Understanding Complex Genome Editing and RNA Biology in Oxytricha
了解尖毛虫中复杂的基因组编辑和 RNA 生物学
- 批准号:
10810440 - 财政年份:2017
- 资助金额:
$ 72.92万 - 项目类别:
Understanding Complex Gene Editing Systems and RNA Biology in Oxytricha
了解尖毛虫中复杂的基因编辑系统和 RNA 生物学
- 批准号:
10198942 - 财政年份:2017
- 资助金额:
$ 72.92万 - 项目类别:
Understanding Complex Genome Editing and RNA Biology in Oxytricha
了解尖毛虫中复杂的基因组编辑和 RNA 生物学
- 批准号:
10823943 - 财政年份:2017
- 资助金额:
$ 72.92万 - 项目类别:
Understanding Complex Genome Editing and RNA Biology in Oxytricha
了解尖毛虫中复杂的基因组编辑和 RNA 生物学
- 批准号:
10415638 - 财政年份:2017
- 资助金额:
$ 72.92万 - 项目类别:
RNA Biology in Oxytricha: a Complex Unicellular Model
尖毛虫中的 RNA 生物学:复杂的单细胞模型
- 批准号:
8888050 - 财政年份:2015
- 资助金额:
$ 72.92万 - 项目类别:
UNDERSTANDING COMPLEX GENE EDITING SYSTEMS IN PROTISTS
了解原生生物的复杂基因编辑系统
- 批准号:
6526065 - 财政年份:1999
- 资助金额:
$ 72.92万 - 项目类别:
Understanding Complex Gene Editing Systems in Protists
了解原生生物中复杂的基因编辑系统
- 批准号:
7736832 - 财政年份:1999
- 资助金额:
$ 72.92万 - 项目类别:
UNDERSTANDING COMPLEX GENE EDITING SYSTEMS IN PROTISTS
了解原生生物的复杂基因编辑系统
- 批准号:
6182038 - 财政年份:1999
- 资助金额:
$ 72.92万 - 项目类别:
"Understanding Complex Gene Editing Systems in Protists"
“了解原生生物的复杂基因编辑系统”
- 批准号:
8581603 - 财政年份:1999
- 资助金额:
$ 72.92万 - 项目类别:
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