The PDX Integrator- Re-purposing KOMP2 informatics to widely disseminate data from Patient Derived Xenografts

PDX Integrator - 重新利用 KOMP2 信息学来广泛传播来自患者来源的异种移植物的数据

• 批准号: 9260869
• 负责人: Helen Elizabeth Parkinson
• 金额: $ 38.35万
• 依托单位: EUROPEAN MOLECULAR BIOLOGY LABORATORY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-15 至 2021-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9260869
• 关键词: American Association of Cancer Research; Archives; Atlases; Automobile Driving; Biological; Biological Assay; Cancer Biology; Cancer Model; Cancer Patient; Common Data Element; Communities; Community Outreach; Complex; Computer software; Data; Data Set; Data Sources; Databases; Development; Disease Progression; Educational workshop; End Point Assay; Engraftment; Environment; Feedback; Funding; Gene Expression; Grant; Graph; Human; Image; Imagery; Immunocompromised Host; Informatics; International; Intuition; Knockout Mice; Knowledge; Learning; Libraries; Link; Location; Maps; Measures; Metadata; Modeling; Molecular Classification of Tumors; Mouse Strains; Mus; Mutant Strains Mice; Mutation; NCI Thesaurus; Oncogenic; Patients; Pharmaceutical Preparations; Pharmacotherapy; Physiological; Procedures; Publications; Research; Research Infrastructure; Research Personnel; Resources; Scientist; Secure; Site; Standardization; Testing; Therapeutic; To specify; Training; Transplantation; Tumor Biology; Work; Xenograft Model; Xenograft procedure; anticancer research; data acquisition; data modeling; data resource; data visualization; experience; genomic data; implantation; informatics infrastructure; meetings; mouse model; neoplasm resource; oncology; phenome; prevent; prototype; public health relevance; repository; response; social media; software development; success; tool; treatment response; tumor; tumor growth; tumor progression; user-friendly

 DESCRIPTION (provided by applicant): Patient Derived Xenografts are a critical and growing resource for cancer biology. They inform the understanding of cancer progression, treatment and represent a valuable and under integrated resource. These data consist of complex Meta data related to the tumor and its progression in mouse model. Omics, drug, assay and image data provide rich characterization of PDXs and offer integration potential with existing tools, dat archives and analysis platforms. The PDX Integrator will build on existing infrastructure developed for the Knockout Mouse Project 2 and has four tasks: 1) Identify key determinants in PDX models, map to existing data standards and work with the community to define, extend and where necessary modify existing standards 2) Extend the existing KOMP2 data acquisition software to acquire, validate and load PDX associated data 3) Deploy the PDX Integrator to provide user friendly overviews of PDX data including biological image data and graphical visualization of end-point data by adapting the KOMP2 resource data visualization and presentation tools. 4) Targeted community outreach during all stages of the project to determine and prioritize requirements, guide development and promote the PDX Integrator.

 描述（由申请人提供）：患者来源的异种移植物是癌症生物学的关键和不断增长的资源。他们告知癌症进展，治疗的理解，并代表了一个宝贵的和整合资源。这些数据包括与肿瘤及其在小鼠模型中的进展相关的复杂Meta数据。组学、药物、分析和图像数据提供了丰富的PDX表征，并提供了与现有工具、数据档案和分析平台的集成潜力。PDX Integrator将建立在为Knockout Mouse Project 2开发的现有基础设施上，并有四项任务：1）确定PDX模型中的关键决定因素，映射到现有的数据标准，并与社区合作定义，扩展和必要时修改现有的标准2）扩展现有的KOMP2数据采集软件，以获取，验证和加载PDX相关数据3）部署PDX Integrator，通过调整KOMP2资源数据可视化和呈现工具，提供用户友好的PDX数据概览，包括生物图像数据和终点数据的图形可视化。4)在项目的所有阶段进行有针对性的社区外展，以确定需求并确定其优先级，指导开发并推广PDX Integrator。