Using electrical nerve stimulation to control atrial fibrillation.

使用电神经刺激来控制心房颤动。

• 批准号: 9807603
• 负责人: PENG-SHENG CHEN
• 金额: $ 70.43万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-23 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9807603
• 关键词: Acute; Atrial Fibrillation; Chronic; Clinical Trials; Electroacupuncture; Frequencies; Future; Human; Nerve; Output; Patients; Skin; Testing; Transcutaneous Electric Nerve Stimulation; Ventricular; conventional therapy; subcutaneous

Study Plan: Using electrical nerve stimulation to control atrial fibrillation Aim 1 will test the hypothesis that subcutaneous (Aim 1A) and transcutaneous (Aim 1B) electrical nerve stimulation are effective in reducing the frequencies of paroxysmal atrial fibrillation (AF) and the ventricular rate in patients with severe symptomatic AF unresponsive to conventional therapies. Aim 2 will test the hypothesis that in healthy subjects, electroacupuncture or TENS at LI-4 and LI-11 can acutely activate or suppress skin sympathetic nerve activity (SKNA). We further hypothesize that chronic TENS will reduce sympathetic output in humans. If confirmed, repeated TENS may be used in the future clinical trials to control AF.

研究计划：使用神经电刺激控制房颤 目标1将检验皮下（目标1A）和经皮（目标1B） 电神经刺激可有效降低阵发性心房颤动的频率， 严重症状性房颤患者的房颤（AF）和心室率对 传统疗法。 目标2将检验以下假设：在健康受试者中，LI-4和LI-4处的电针或TENS LI-11可以急性激活或抑制皮肤交感神经活动（SKNA）。我们进一步 假设慢性TENS将减少人类的交感神经输出。如果得到证实， 重复的TENS可以在未来的临床试验中用于控制AF。