Using electrical nerve stimulation to control atrial fibrillation.
Using electrical nerve stimulation to control atrial fibrillation.
批准号:
9807603
负责人:
PENG-SHENG CHEN
金额:
$70.43万
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
已结题
起止时间:
2019-07-23 至 2020-06-30
中文摘要
研究计划:使用神经电刺激控制房颤
目标1将检验皮下(目标1A)和经皮(目标1B)
电神经刺激可有效降低阵发性心房颤动的频率,
严重症状性房颤患者的房颤(AF)和心室率对
传统疗法。
目的2将检验以下假设:在健康受试者中,在LI-4和
LI-11可以急性激活或抑制皮肤交感神经活动(SKNA)。我们进一步
假设慢性TENS将减少人类的交感神经输出。如果得到证实,
重复的TENS可以在未来的临床试验中用于控制AF。
英文摘要
Study Plan: Using electrical nerve stimulation to control atrial fibrillation
Aim 1 will test the hypothesis that subcutaneous (Aim 1A) and transcutaneous (Aim 1B)
electrical nerve stimulation are effective in reducing the frequencies of paroxysmal atrial
fibrillation (AF) and the ventricular rate in patients with severe symptomatic AF unresponsive to
conventional therapies.
Aim 2 will test the hypothesis that in healthy subjects, electroacupuncture or TENS at LI-4 and
LI-11 can acutely activate or suppress skin sympathetic nerve activity (SKNA). We further
hypothesize that chronic TENS will reduce sympathetic output in humans. If confirmed,
repeated TENS may be used in the future clinical trials to control AF.
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会议论文
Using electrical nerve stimulation to control atrial fibrillation
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批准号:10397354
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项目类别:
-
资助金额:$93.73万
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财政年份:2020
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负责人:PENG-SHENG CHEN
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依托单位:
SK current and ventricular arrhythmias.
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批准号:10164095
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项目类别:
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资助金额:$56.18万
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财政年份:2017
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负责人:PENG-SHENG CHEN
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依托单位:
Subcutaneous nerve stimulation for arrhythmia control.
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批准号:9405146
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项目类别:
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资助金额:$67.65万
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财政年份:2017
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负责人:PENG-SHENG CHEN
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依托单位:
SK Current, beta-3 adrenoceptor activation and Sex Differences in Ventricular Arrhythmogenesis
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批准号:10734708
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项目类别:
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资助金额:$59.43万
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财政年份:2017
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负责人:PENG-SHENG CHEN
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依托单位:
Autonomic Nerve Activity and Paroxysmal Atrial Fibrillation
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批准号:7822294
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项目类别:
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资助金额:$1.79万
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财政年份:2009
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负责人:PENG-SHENG CHEN
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依托单位:
WAVE DYNAMICS IN NORMAL AND DISEASED RABBIT HEARTS
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批准号:7108467
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项目类别:
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资助金额:$35.9万
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财政年份:2005
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负责人:PENG-SHENG CHEN
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依托单位:
Fibrillation and Defibrillation
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批准号:7171857
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项目类别:
-
资助金额:$35.91万
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财政年份:2005
-
负责人:PENG-SHENG CHEN
-
依托单位:
Fibrillation and Defibrillation
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批准号:7500776
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项目类别:
-
资助金额:$35.91万
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财政年份:2005
-
负责人:PENG-SHENG CHEN
-
依托单位:
Fibrillation and Defibrillation
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批准号:7741761
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项目类别:
-
资助金额:$38.5万
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财政年份:2005
-
负责人:PENG-SHENG CHEN
-
依托单位:
Fibrillation and Defibrillation
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批准号:7012199
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项目类别:
-
资助金额:$38.08万
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财政年份:2005
-
负责人:PENG-SHENG CHEN
-
依托单位:
Fibrillation and Defibrillation
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批准号:7923953
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项目类别:
-
资助金额:$38.26万
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财政年份:2005
-
负责人:PENG-SHENG CHEN
-
依托单位:
Fibrillation and Defibrillation
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批准号:6849511
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项目类别:
-
资助金额:$39.0万
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财政年份:2005
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负责人:PENG-SHENG CHEN
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依托单位:
Thoracic Veins and Sustained Atrial Fibrillation
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批准号:6637740
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项目类别:
-
资助金额:$36.08万
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财政年份:2002
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负责人:PENG-SHENG CHEN
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依托单位:
Thoracic Veins and Sustained Atrial Fibrillation
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批准号:6531379
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项目类别:
-
资助金额:$37.4万
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财政年份:2002
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负责人:PENG-SHENG CHEN
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依托单位:
REENTRANT WAVEFRONTS IN VENTRICULAR FIBRILLATION
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批准号:6564938
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项目类别:
-
资助金额:$23.8万
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财政年份:2002
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负责人:PENG-SHENG CHEN
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依托单位:
Autonomic Nerve Activity and Paroxysmal Atrial Fibrillation
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批准号:7492935
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项目类别:
-
资助金额:$37.75万
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财政年份:2002
-
负责人:PENG-SHENG CHEN
-
依托单位:
Thoracic Veins and Sustained Atrial Fibrillation
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批准号:6921915
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项目类别:
-
资助金额:$36.08万
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财政年份:2002
-
负责人:PENG-SHENG CHEN
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依托单位:
Autonomic Nerve Activity and Paroxysmal Atrial Fibrillation
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批准号:7921900
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项目类别:
-
资助金额:$7.92万
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财政年份:2002
-
负责人:PENG-SHENG CHEN
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依托单位:
Autonomic Nerve Activity and Paroxysmal Atrial Fibrillation
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批准号:8193778
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项目类别:
-
资助金额:$38.5万
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财政年份:2002
-
负责人:PENG-SHENG CHEN
-
依托单位:
Thoracic Veins and Sustained Atrial Fibrillation
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批准号:6787644
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项目类别:
-
资助金额:$36.08万
-
财政年份:2002
-
负责人:PENG-SHENG CHEN
-
依托单位:
海外基金