Using electrical nerve stimulation to control atrial fibrillation

使用电神经刺激来控制心房颤动

• 批准号: 10397354
• 负责人: PENG-SHENG CHEN
• 金额: $ 93.73万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10397354
• 关键词: Using; electrical; nerve; stimulation; control

Study Plan: Using electrical nerve stimulation to control atrial fibrillation Aim 1 will test the hypothesis that subcutaneous (Aim 1A) and transcutaneous (Aim 1B) electrical nerve stimulation are effective in reducing the frequencies of paroxysmal atrial fibrillation (AF) and the ventricular rate in patients with severe symptomatic AF unresponsive to conventional therapies. Aim 2 will test the hypothesis that in healthy subjects, electroacupuncture or TENS at LI-4 and LI-11 can acutely activate or suppress skin sympathetic nerve activity (SKNA). We further hypothesize that chronic TENS will reduce sympathetic output in humans. If confirmed, repeated TENS may be used in the future clinical trials to control AF.

研究计划：使用电神经刺激控制心房颤动 目标1将检验皮下(目标1A)和经皮(目标1B)的假设 电刺激能有效降低阵发性心房颤动的发生频率 严重症状性房颤无反应患者的房颤和心室率 传统疗法。 目标2将检验这一假设，即在健康受试者中，电针或TENS在LI-4和 Li-11对皮肤交感神经活动(SKNA)有明显的激活或抑制作用。我们进一步 假设慢性TENS会减少人类的交感神经输出。如果得到确认， 重复的TENS可用于未来的临床试验以控制房颤。

项目成果

Neural Remodeling After Myocardial Infarction: The Importance of Heterogeneity.

心肌梗死后的神经重塑：异质性的重要性。

• DOI: 10.1016/j.jacep.2023.05.027
• 发表时间: 2023
• 期刊: JACC. Clinical electrophysiology
• 作者: Chen,Peng-Sheng;Fishbein,MichaelC
• 通讯作者: Fishbein,MichaelC

Sympathetic toggled sinus rate acceleration as a mechanism of sustained sinus tachycardia in chronic orthostatic intolerance syndrome.

交感神经窦性心率加速是慢性直立不耐受综合征持续窦性心动过速的机制。

• DOI: 10.1016/j.hrthm.2022.08.015
• 发表时间: 2022
• 期刊: Heart rhythm
• 影响因子: 5.5
• 作者: Hwang,Daerin;Liu,Xiao;Rosenberg,Carine;Lee,Andrew;Borle,Sanjana;Ricafrente,JoselynQ;Wei,Janet;Shufelt,Chrisandra;Chen,LanS;Li,Xiaochun;Goldhaber,JoshuaI;BaireyMerz,CNoel;Chen,Peng-Sheng
• 通讯作者: Chen,Peng-Sheng

The regulation of the small-conductance calcium-activated potassium current and the mechanisms of sex dimorphism in J wave syndrome.

J波综合征小电导钙激活钾电流的调节及性别二态性机制

• DOI: 10.1007/s00424-020-02500-3
• 发表时间: 2021-03
• 期刊: Pflugers Archiv : European journal of physiology
• 作者: Chen M;Fei Y;Chen TZ;Li YG;Chen PS
• 通讯作者: Chen PS

Simultaneous activation of the small conductance calcium-activated potassium current by acetylcholine and inhibition of sodium current by ajmaline cause J-wave syndrome in Langendorff-perfused rabbit ventricles.

• DOI: 10.1016/j.hrthm.2020.07.036
• 发表时间: 2021-01
• 期刊: Heart rhythm
• 影响因子: 5.5
• 作者: Fei YD;Chen M;Guo S;Ueoka A;Chen Z;Rubart-von der Lohe M;Everett TH 4th;Qu Z;Weiss JN;Chen PS
• 通讯作者: Chen PS

Deep learning evaluation of echocardiograms to identify occult atrial fibrillation.

超声心动图的深度学习评估以识别隐匿性心房颤动。

• DOI: 10.1038/s41746-024-01090-z
• 发表时间: 2024
• 期刊: NPJ digital medicine
• 影响因子: 15.2
• 作者: Yuan,Neal;Stein,NathanR;Duffy,Grant;Sandhu,RoopinderK;Chugh,SumeetS;Chen,Peng-Sheng;Rosenberg,Carine;Albert,ChristineM;Cheng,Susan;Siegel,RobertJ;Ouyang,David
• 通讯作者: Ouyang,David