Using electrical nerve stimulation to control atrial fibrillation

使用电神经刺激来控制心房颤动

• 批准号: 10397354
• 负责人: PENG-SHENG CHEN
• 金额: $ 93.73万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10397354
• 关键词: Using; electrical; nerve; stimulation; control

Study Plan: Using electrical nerve stimulation to control atrial fibrillation Aim 1 will test the hypothesis that subcutaneous (Aim 1A) and transcutaneous (Aim 1B) electrical nerve stimulation are effective in reducing the frequencies of paroxysmal atrial fibrillation (AF) and the ventricular rate in patients with severe symptomatic AF unresponsive to conventional therapies. Aim 2 will test the hypothesis that in healthy subjects, electroacupuncture or TENS at LI-4 and LI-11 can acutely activate or suppress skin sympathetic nerve activity (SKNA). We further hypothesize that chronic TENS will reduce sympathetic output in humans. If confirmed, repeated TENS may be used in the future clinical trials to control AF.

研究计划：使用电神经刺激控制心房颤动 AIM 1将检验地下（AIM 1A）和经皮（AIM 1B）的假设 电神经刺激可有效降低阵发性心房的频率 严重症状AF的患者的纤颤（AF）和心室率无反应 常规疗法。 AIM 2将检验以下假设：在健康受试者中，在LI-4和 Li-11可以急性激活或抑制皮肤交感神经活性（SKNA）。我们进一步 假设慢性数TEN将减少人类的交感神经产出。如果确认， 在将来的临床试验中可以使用重复数TENS来控制AF。

项目成果

Neural Remodeling After Myocardial Infarction: The Importance of Heterogeneity.

心肌梗死后的神经重塑：异质性的重要性。

• DOI: 10.1016/j.jacep.2023.05.027
• 发表时间: 2023
• 期刊: JACC. Clinical electrophysiology
• 作者: Chen,Peng-Sheng;Fishbein,MichaelC
• 通讯作者: Fishbein,MichaelC

Sympathetic toggled sinus rate acceleration as a mechanism of sustained sinus tachycardia in chronic orthostatic intolerance syndrome.

交感神经窦性心率加速是慢性直立不耐受综合征持续窦性心动过速的机制。

• DOI: 10.1016/j.hrthm.2022.08.015
• 发表时间: 2022
• 期刊: Heart rhythm
• 影响因子: 5.5
• 作者: Hwang,Daerin;Liu,Xiao;Rosenberg,Carine;Lee,Andrew;Borle,Sanjana;Ricafrente,JoselynQ;Wei,Janet;Shufelt,Chrisandra;Chen,LanS;Li,Xiaochun;Goldhaber,JoshuaI;BaireyMerz,CNoel;Chen,Peng-Sheng
• 通讯作者: Chen,Peng-Sheng

Simultaneous activation of the small conductance calcium-activated potassium current by acetylcholine and inhibition of sodium current by ajmaline cause J-wave syndrome in Langendorff-perfused rabbit ventricles.

• DOI: 10.1016/j.hrthm.2020.07.036
• 发表时间: 2021-01
• 期刊: Heart rhythm
• 影响因子: 5.5
• 作者: Fei YD;Chen M;Guo S;Ueoka A;Chen Z;Rubart-von der Lohe M;Everett TH 4th;Qu Z;Weiss JN;Chen PS
• 通讯作者: Chen PS

Deep learning evaluation of echocardiograms to identify occult atrial fibrillation.

超声心动图的深度学习评估以识别隐匿性心房颤动。

• DOI: 10.1038/s41746-024-01090-z
• 发表时间: 2024
• 期刊: NPJ digital medicine
• 影响因子: 15.2
• 作者: Yuan,Neal;Stein,NathanR;Duffy,Grant;Sandhu,RoopinderK;Chugh,SumeetS;Chen,Peng-Sheng;Rosenberg,Carine;Albert,ChristineM;Cheng,Susan;Siegel,RobertJ;Ouyang,David
• 通讯作者: Ouyang,David

The regulation of the small-conductance calcium-activated potassium current and the mechanisms of sex dimorphism in J wave syndrome.

J波综合征小电导钙激活钾电流的调节及性别二态性机制

• DOI: 10.1007/s00424-020-02500-3
• 发表时间: 2021-03
• 期刊: Pflugers Archiv : European journal of physiology
• 作者: Chen M;Fei Y;Chen TZ;Li YG;Chen PS
• 通讯作者: Chen PS