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Translational models of brain activation patterns during nicotine self-administration and reinstatement

尼古丁自我给药和恢复过程中大脑激活模式的转化模型

基本信息

批准号：
9249013
负责人：
Stephen John Kohut
金额：
$ 17.94万
依托单位：
MCLEAN HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-04-01 至 2020-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9249013
关键词：
Address Agonist Amygdaloid structure Anterior Area Attenuated Award Behavior Behavioral Brain Brain imaging Brain region Cardiovascular system Cessation of life Chantix Clinical Complement Cost of Illness Coupled Cues Data Data Analyses Detection Development Dorsal Dose Drug Addiction Drug Modelings Drug abuse Drug effect disorder Extinction (Psychology)Foundations Funding Future General Hospitals Goals Habenula Hypothalamic structure Image Image Analysis Imaging Techniques Insula of Reil Knowledge Laboratories Lung diseases Macaca Macaca mulatta Magnetic Resonance Magnetic Resonance Imaging Malignant Neoplasms Massachusetts Measures Mediating Mentored Research Scientist Development Award Mentors Methodology Modeling Mus Neurobiology Neurons Neurosciences Research Nicotine Nicotine Dependence Nucleus Accumbens Pattern Pharmaceutical Preparations Pharmacology Phase Preparation Process Relapse Research Research Personnel Research Project Grants Research Proposals Research Training Resolution Rewards Scientist Self Administration Series Signal Transduction Societies Supervision Testing Thalamic structure Time Training Training Programs United States Ventral Tegmental Area Work Writing addiction awake base career career development cue reactivity design drug of abuse drug reinforcement economic cost effective therapy experience experimental study imaging study innovation interpeduncular nucleus investigator training man meetings multidisciplinary neural correlate neuroimaging nonhuman primate novel pre-clinical programs public health relevance relating to nervous system response skills smoking cessation tool treatment strategy varenicline

项目摘要

DESCRIPTION (provided by applicant): Neuroimaging methodologies have become increasingly important tools in neuroscience research, providing a means for understanding the neural substrates related to drug action. This K01 Award will provide support and protected time for Dr. Stephen Kohut to obtain additional experience and mentoring that will complement and expand his existing expertise in preclinical IV drug self-administration and medication testing by acquiring new skills in pharmacologic magnetic resonance imaging (phMRI). During the proposed award period the PI will first complete an intensive training program to develop the core skills and knowledge necessary to design, conduct, and analyze phMRI studies. Training will occur at the McLean Imaging Center and Massachusetts General Hospital and will involve coursework and seminars, and discussions and meetings with a world-renowned mentoring team that will facilitate completion of an innovative research project. A major strength of the research project is that it will optimize the PI's training experience through a systematic series f experiments evaluating neuronal function during the phases of drug addiction typically modeled in the laboratory including IV self-administration (i.e., drug-taking) and reinstatement (i.e., relapse) and the effects of novel treatment approaches (pharmacological and/or behavioral) in non-human primates (NHP). Another major strength of the research plan, which will have a major impact on the field, is that it involves the use of awake, behaving NHP to study the functional consequences of nicotine self-administration and reinstatement and how they are altered during treatment. Functional brain activity in multiple brain regions will be directly relaed to ongoing "real time" behavior that can be measured within and across behavioral sessions. Focused research training in phMRI will occur at 3 Tesla (3T) through the Research Plan, but the PI will also receive training on a state-of-the-art, ultra-high field 9.4T magnet, large enough to accommodate NHP. The combination of training at clinical field strength (3T) coupled with training at ultra-high field strength (9.4T) will equip the Candidate with the knowledge and skills necessary to become an R01-funded independent investigator at the forefront of truly translational addiction research relating behavior and brain function. Overall, this training experience will allow the Candidate to develop a novel investigative approach for examining how novel treatments influence the various neuronal effects of nicotine and other drugs of abuse during periods of drug-taking and relapse, and will establish the PI as an independent scientist who is qualified to conduct highly translational addiction research that will address the need for highly trained investigators who can explore the neural correlates of drug abuse and addiction.