Illuminating the functions of CACNA2D4 in the brain
阐明 CACNA2D4 在大脑中的功能
基本信息
- 批准号:9813213
- 负责人:
- 金额:$ 15.45万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-08-15 至 2021-07-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAffectiveAnimal ModelAntibodiesAnxietyBehaviorBehavioralBipolar DisorderBrainCAV1 geneCell membraneCellsCognitiveComplexDefectDiseaseEpilepsyEtiologyFailureFutureGenesGeneticGenetic TranscriptionGenetic studyGoalsHuman GeneticsImmunohistochemistryImpairmentIn Situ HybridizationIon Channel ProteinKnockout MiceLightMaintenanceMental DepressionMissionModelingMusMutationNervous system structureNeuronsNeurophysiology - biologic functionOutcomeOutcomes ResearchPatientsPhenotypePlayPresynaptic TerminalsProcessProtein FamilyProteinsResearchRetinaRetinal PhotoreceptorsRoleSchizophreniaShapesShort-Term MemorySignal TransductionSiteStructureTimeVariantVisionVisualautism spectrum disorderbasedensitydesignendophenotypeexperimental studyextracellularhuman diseaseinsightknockout animalloss of functionloss of function mutationmembermouse modelneural circuitneuropsychiatric disorderneurotransmitter releasenovelpainful neuropathypolyclonal antibodypresynapticreceptorsynaptogenesistoolvoltage
项目摘要
Project Summary
Variants in the genes that encode voltage-gated Ca2+ channels are consistently and robustly
associated with schizophrenia, bipolar disorder, and autism spectrum disorder. One of these
genes is CACNA2D4, an IDG-elibigle gene that encodes an extracellular Ca2+ channel
subunit (2-4) expressed in both the brain and retina. In the case of the retina, it has been
established that 2-4 is required for normal vision. By contrast, the role of this protein in the
brain remains understudied; we known neither where in the brain it acts nor what functions it
may have there. The long-term goal of this project is to understand how genetic alterations
in Cav-channel contributes to the complex etiology of neuropsychiatric disorders. The overall
objective of the proposed research is to establish the cellular distribution of 2-4 in the
mouse brain and which behaviors are disrupted in mice lacking this protein. The specific
aims are to (1) define the neural circuits that may be regulated by 2–4 in the mouse brain
and (2) identify cognitive/affective phenotypes in 2-4 knock-out mice. To accomplish these
aims, we will use antibodies against 2–4 in immunohistochemical analyses of mouse
brain, and behavioral analyses designed to uncover alterations in cognitive or affective
function in mice.
项目摘要
编码电压门控钙通道的基因的变异是始终如一且强劲的
与精神分裂症、双相情感障碍和自闭症谱系障碍有关。这其中的一个
基因是CACNA2D4,一个编码细胞外钙通道的IDG-eligigle基因
亚基(2,-4)在脑和视网膜中均有表达。就视网膜而言,它一直是
已确定正常视力需要2-4。相比之下,这种蛋白质在细胞内的作用
大脑仍然缺乏研究;我们既不知道它在大脑中的作用,也不知道它的功能是什么
可能就在那里。这个项目的长期目标是了解基因改变是如何
在Cav-通道中,神经精神障碍的复杂病因起着重要作用。整体而言
本研究的目的是建立-2-4在人卵巢癌组织中的细胞分布。
缺乏这种蛋白质的小鼠的大脑和哪些行为受到干扰。具体的
目的是(1)确定小鼠大脑中可能受2-4调控的神经回路
以及(2)确定2-4基因敲除小鼠的认知/情感表型。要实现这些目标
目的:我们将使用抗-2-4抗体对小鼠进行免疫组织化学分析。
大脑,以及旨在揭示认知或情感变化的行为分析
在小鼠身上起作用。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
AMY LEE其他文献
AMY LEE的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('AMY LEE', 18)}}的其他基金
Modulation of Cav 1.3 L-type Ca2+ channels by PDZ-protein interactions
PDZ-蛋白质相互作用对 Cav 1.3 L 型 Ca2 通道的调节
- 批准号:
7581009 - 财政年份:2009
- 资助金额:
$ 15.45万 - 项目类别:
Modulation of Cav 1.3 L-type Ca2+ channels by PDZ-protein interactions
PDZ-蛋白质相互作用对 Cav 1.3 L 型 Ca2 通道的调节
- 批准号:
8270567 - 财政年份:2009
- 资助金额:
$ 15.45万 - 项目类别:
Modulation of Cav 1.3 L-type Ca2+ channels by PDZ-protein interactions
PDZ-蛋白质相互作用对 Cav 1.3 L 型 Ca2 通道的调节
- 批准号:
7798590 - 财政年份:2009
- 资助金额:
$ 15.45万 - 项目类别:
相似海外基金
Affective Virality on Social Media: The Role of Culture and Ideal Affect
社交媒体上的情感病毒传播:文化和理想情感的作用
- 批准号:
2214203 - 财政年份:2022
- 资助金额:
$ 15.45万 - 项目类别:
Standard Grant
'Essaying Affect: the contemporary essay as a place of affective possibility'
“散文情感:当代散文作为情感可能性的场所”
- 批准号:
2438692 - 财政年份:2020
- 资助金额:
$ 15.45万 - 项目类别:
Studentship
Influence of Physical Activity on Daily Positive Affect & Affective Neural Activity in Preschoolers
体力活动对日常积极影响的影响
- 批准号:
10231121 - 财政年份:2018
- 资助金额:
$ 15.45万 - 项目类别:
Influence of Physical Activity on Daily Positive Affect & Affective Neural Activity in Preschoolers
体力活动对日常积极影响的影响
- 批准号:
10475608 - 财政年份:2018
- 资助金额:
$ 15.45万 - 项目类别:
Influence of Physical Activity on Daily Positive Affect & Affective Neural Activity in Preschoolers
体力活动对日常积极影响的影响
- 批准号:
10474838 - 财政年份:2018
- 资助金额:
$ 15.45万 - 项目类别:
Affect- and Psychotechnolog Studies. Emergent Technologies of Affective and Emotional (Self-)Control
影响和心理技术研究。
- 批准号:
279966032 - 财政年份:2015
- 资助金额:
$ 15.45万 - 项目类别:
Scientific Networks
Does minute listeners' head movement affect affective aspects of human spatial hearing perception?
听众的微小头部运动是否会影响人类空间听觉感知的情感方面?
- 批准号:
26540093 - 财政年份:2014
- 资助金额:
$ 15.45万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
RI: Small: An Affect-Adaptive Spoken Dialogue System that Responds Based on User Model and Multiple Affective States
RI:Small:基于用户模型和多种情感状态进行响应的情感自适应口语对话系统
- 批准号:
0914615 - 财政年份:2009
- 资助金额:
$ 15.45万 - 项目类别:
Standard Grant
Affective Rendering ? Toward the Realization of Affect Adapted Image Synthesis
情感渲染?
- 批准号:
21300033 - 财政年份:2009
- 资助金额:
$ 15.45万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
A Study by Means of Analysis of Structure of Covariunce, on Factors which Affect Japanese Language Acquisition and Mother Tongue Maintenance of Children from Overseas-an Integral Study of Cognitive Linguistic / Affective / Socio Cultural Factors-
协方差结构分析影响海外儿童日语习得和母语维持的因素研究-认知语言/情感/社会文化因素的综合研究-
- 批准号:
11480051 - 财政年份:1999
- 资助金额:
$ 15.45万 - 项目类别:
Grant-in-Aid for Scientific Research (B)














{{item.name}}会员




