Integrating Neurobiology and Neuroimaging into Research on Addiction and PTSD

将神经生物学和神经影像学整合到成瘾和创伤后应激障碍的研究中

• 批准号: 9313226
• 负责人: SUDIE E BACK
• 金额: $ 15.59万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9313226
• 关键词: Address; Affect; Aftercare; Alcohol consumption; Area; Award; Behavior Therapy; Chronic Disease; Clinical; Clinical Psychology; Clinical Research; Cognitive Therapy; Collaborations; Comorbidity; Consultations; Cues; Data; Data Set; Dedications; Development; Development Plans; Disease; Drug abuse; Drug usage; Educational workshop; Evidence based intervention; Evidence based treatment; Faculty; Family; Feeling suicidal; Foundations; Freedom; Functional Magnetic Resonance Imaging; Funding; Future; Goals; Growth; HIV risk; Health; Health Expenditures; Homelessness; Human; Image; Image Analysis; Impairment; Independent Scientist Award; Individual; Institutes; Interdisciplinary Study; Interview; Knowledge; Laboratories; Learning; Legal; Literature; Magnetic Resonance Imaging; Medical; Memory; Mental Depression; Mental Health; Mental disorders; Mentors; Mentorship; Methodology; Military Personnel; National Institute of Drug Abuse; Neurobiology; Neurosciences; Nightmare; Outcome; Participant; Patient Care; Pharmaceutical Preparations; Post-Traumatic Stress Disorders; Protocols documentation; Psychiatry; Psychologist; Psychotherapy; Public Health; Randomized Controlled Trials; Readiness; Reading; Reporting; Research; Research Design; Research Peer Review; Research Personnel; Research Support; Risk Behaviors; Science; Scientist; Services; Severities; Signal Transduction; Solid; Stress; Structure; Study Section; Substance Use Disorder; Suicide attempt; Supervision; Symptoms; Time; Training; Training Activity; Trauma; Treatment outcome; Unemployment; Universities; Veterans; addiction; base; career; career development; clinical diagnostics; cognitive development; comparative efficacy; data acquisition; disorder later incidence prevention; experience; faculty support; improved; knowledge base; multidisciplinary; neuroimaging; neuromechanism; novel; operation; programs; public health relevance; reduced substance use; research and development; safety and feasibility; satisfaction; skills; stress disorder; success; symptomatology; theories; traumatic event; treatment adherence; tutoring

 DESCRIPTION (provided by applicant): This K02 Independent Scientist Award will significantly expand my potential to make important contributions to the field of drug abuse by increasing my knowledge of the neurobiology of addictions and allowing me to obtain expertise in neuroimaging and image analysis methodology. Over the past 17 years, my program of research has focused on substance use disorders (SUD), stress, and co-occurring posttraumatic stress disorder (PTSD), with a particular focus on the development of theory-based, concurrent behavioral interventions for comorbid SUD/PTSD. As a licensed clinical psychologist, my training and background has afforded me skills in research design, structured clinical and diagnostic interviews, conduct of randomized controlled trials, psychotherapy development, and human laboratory paradigms. In the last 20 years, extraordinary methodologic advances have led to incredible growth in understanding the neurobiologic underpinnings of addictions and other psychiatric disorders. The Psychiatry and Neuroscience Departments at MUSC have a constellation of faculty who have been leaders in research in this area. There has also been exponential growth in neuroimaging expertise on the MUSC campus, providing an opportunity for me to learn from and collaborate with world-renowned experts. My ongoing NIDA-sponsored R01 is a randomized controlled trial (RCT) of integrated treatment for SUD and PTSD among Veterans (R01 DA030143). Through collaborations with the MUSC imaging group, a protocol to obtain functional magnetic resonance imaging (fMRI) before and after treatment was added to my R01 project to permit examination of neural mechanisms underlying SUD/PTSD comorbidity and identify potential targets for treatment. However, my lack of formal training in neurobiology, neuroimaging and image analysis methodology will limit my ability to realize the full potential of the data collected. Thus, the primary career development goals of this K02 application are: (1) To obtain training in the neurobiology of both SUD and PTSD in order to better understand the neurobiologic SUD/PTSD interface; (2) To gain a solid foundation in neuroimaging and image analysis methodology in order to apply these skills to the analysis of the fMRI data from my current R01, other neuroimaging data available at my institute, and future research efforts; and (3) To continue professional development in areas critical to academic success, such as, mentorship of junior scientists and multidisciplinary collaborations. These goals represent a logical and synergistic expansion of my current expertise. The training provided will enhance the value of currently funded projects as well as those that are under review. Although my existing skill set will allow me to accomplish the Specific Aims of my current R01, I need additional training to fully utilize the neuroimaging data and to ask novel and meaningful questions that are on the cutting edge of drug abuse research. The K02 award will allow me to benefit from formal coursework and workshops, directed readings, individual tutoring and consultation with leaders in the field, hands-on training in brai imaging data acquisition, MRI methodology (e.g., functional and structural MRI, BOLD signal activation), image analysis methodology, and supervised practical experience analyzing relevant datasets. In summary, the overarching goal of the proposed K02 is to further my multidisciplinary independent program of research aimed at the development of evidence-based interventions for SUD and co-occurring PTSD. This award will provide me with the protected time necessary to fully engage in the training activities outlined in the career development plan, enabling me to take full advantage of expertise on the MUSC campus to enhance my skill set and knowledge base in order to move my research program forward in ways not currently possible without additional training.

 描述（由申请人提供）：这个 K02 独立科学家奖将通过增加我对成瘾神经生物学的了解并让我获得神经影像和图像分析方法方面的专业知识，显着扩大我在药物滥用领域做出重要贡献的潜力。在过去的 17 年里，我的研究项目主要集中在物质使用障碍 (SUD)、压力和同时发生的创伤后应激障碍 (PTSD)，特别关注针对共病 SUD/PTSD 开发基于理论的同步行为干预措施。作为一名有执照的临床心理学家，我的培训和背景为我提供了研究设计、结构化临床和诊断访谈、随机对照试验的进行、心理治疗开发和人类实验室范例方面的技能。在过去的 20 年里，非凡的方法学进步使得人们对成瘾和其他精神疾病的神经生物学基础的理解取得了令人难以置信的进展。 MUSC 的精神病学和神经科学系拥有一批在该领域研究领域处于领先地位的教师。 MUSC 校园的神经影像专业知识也呈指数级增长，为我提供了向世界知名专家学习和合作的机会。我正在进行的 NIDA 赞助的 R01 是一项针对退伍军人 SUD 和 PTSD 综合治疗的随机对照试验 (RCT) (R01 DA030143)。通过与 MUSC 成像小组的合作，我的 R01 项目中添加了治疗前后获得功能磁共振成像 (fMRI) 的协议，以便检查 SUD/PTSD 共病的神经机制并确定潜在的治疗目标。然而，我缺乏神经生物学、神经影像学和图像分析方法方面的正式培训，这将限制我充分发挥所收集数据潜力的能力。因此，本次K02申请的主要职业发展目标是：（1）获得SUD和PTSD神经生物学方面的培训，以便更好地理解神经生物学SUD/PTSD界面； (2) 在神经影像和图像分析方法方面打下坚实的基础，以便将这些技能应用于我当前 R01 的 fMRI 数据、我研究所可用的其他神经影像数据以及未来的研究工作的分析； (3) 继续在对学术成功至关重要的领域进行专业发展，例如对初级科学家的指导和多学科合作。这些目标代表了我当前专业知识的逻辑和协同扩展。提供的培训将提高当前资助项目以及正在审查的项目的价值。虽然我现有的技能将使我能够实现当前 R01 的具体目标，但我需要额外的培训才能充分利用神经影像数据并提出药物滥用研究前沿的新颖且有意义的问题。 K02 奖将使我受益于正式课程和研讨会、定向阅读、个人辅导和与该领域领导者的咨询、脑成像数据采集的实践培训、MRI 方法（例如功能和结构 MRI、BOLD 信号激活）、图像分析方法以及分析相关数据集的监督实践经验。总之，拟议的 K02 的总体目标是进一步推进我的多学科独立研究计划，旨在开发针对 SUD 和同时发生的 PTSD 的循证干预措施。该奖项将为我提供充分参与职业发展计划中概述的培训活动所需的受保护时间，使我能够充分利用 MUSC 校园的专业知识来增强我的技能和知识基础，以便以目前在没有额外培训的情况下不可能实现的方式推进我的研究计划。