Effect of Alcohol Use on Waterpipe Smoking Patterns and Toxicant Exposure

饮酒对水烟吸烟模式和有毒物质暴露的影响

• 批准号: 9350154
• 负责人: Eleanor Ladd Schneider Leavens
• 金额: $ 4.35万
• 依托单位: OKLAHOMA STATE UNIVERSITY STILLWATER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-15 至 2018-08-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9350154
• 关键词: Acute; Address; Air; Alcohol consumption; Alcohols; Aromatic Polycyclic Hydrocarbons; Benzene; Breathing; Carbon Monoxide; Cardiovascular Diseases; Charcoal; Cigarette; Community Health; Crossover Design; Dependence; Devices; Drug Interactions; Exhalation; Exposure to; Flavoring; Foundations; Health; Heating; Heavy Metals; Hour; Investigation; Knowledge; Laboratory Study; Learning; Literature; Lung diseases; Maintenance; Malignant Neoplasms; Measures; Mediating; Methods; Nicotine; Outcome; Palate; Patient Self-Report; Pattern; Pharmaceutical Preparations; Placebo Control; Placebos; Plasma; Public Health; Randomized; Reporting; Research; Role; Sales; Serum; Smoke; Smoker; Smoking; Smoking Behavior; Tars; Time; Tobacco; Tobacco use; Toxicant exposure; Training; Water; alcohol abstinence; alcohol effect; cigarette smoking; cigarette smoking; experience; hookah; innovation; interdisciplinary collaboration; novel; primary outcome; respiratory; satisfaction; secondary outcome; smoke inhalation; social; tobacco abstinence; toxicant; willingness; young adult

Project Title: Effect of Alcohol Use on Waterpipe Smoking Patterns and Toxicant Exposure Project Summary/ Abstract: Waterpipe (WP) smoking in the US is on the rise and beginning to overtake cigarettes as the most popular method of tobacco use among young adults. Unfortunately, WP smoking is associated with many of the same negative health outcomes as cigarettes such as cancer, lung disease, respiratory illness, and cardiovascular disease. The co-occurrence of alcohol use and WP smoking is quite common among young adults. Relative to those who do not use WP, WP smokers are estimated to be more than twice as likely to use alcohol and frequently consume alcohol immediately before or during a WP smoking session. Of concern, the cigarette smoking literature suggests that smokers smoke more cigarettes when they drink alcohol and have a more difficult time abstaining from smoking, resulting in more exposure to nicotine and tobacco-related toxicants. These findings cannot be directly applied to WP smoking due to unique aspects of WP smoking (e.g., smoking patterns, smoke may be easier to inhale, WP is typically smoked in groups). To date, no study has experimentally and systematically investigated the impact of alcohol on WP smoking behaviors, resultant exposure to tobacco-related toxicants, or abuse liability. The proposed study will provide this needed scientific evidence. Using a randomized crossover-design, 40 current WP smokers will complete two counterbalanced WP smoking sessions (alcohol vs. placebo) that are preceded by 24 hours of alcohol abstinence and 12-hour tobacco abstinence. Sessions will be separated by a standard 48-hour washout period, and WP tobacco nicotine levels will be held constant across sessions. Measures of smoking behavior (puff topography) and acute toxicant exposure (CO boost and plasma nicotine) will be collected, in addition to self-report measures of abuse liability, intentions for continued use, and importance of concurrent alcohol consumption for using WP. If alcohol consumption were determined to influence users to initially try WP, increase their willingness to continue to use the product, and/or make it more palatable to puff more frequently or take longer/deeper puffs, then concurrent alcohol use would be contributing to the initiation and maintenance of WP dependence. This innovative study, in its systematic examination of the impact of co-use of alcohol and WP, will provide the scientific foundation needed to establish effective regulatory strategies for the distribution and sales of WP tobacco and alcohol. In addition, this project will serve as an incredibly valuable training experience by providing an opportunity to learn new assessments of WP smoking and drug-drug interactions while learning from leading experts in the field of WP smoking and gaining an appreciation for interdisciplinary collaboration.

项目名称：酒精使用对水管吸烟模式和有毒物质暴露的影响 项目概要/摘要： 在美国，水管（WP）吸烟呈上升趋势，并开始超过香烟成为最受欢迎的吸烟方式。 年轻人的烟草使用方法。不幸的是，WP吸烟与许多相同的 吸烟会对健康产生负面影响，例如癌症、肺病、呼吸道疾病和心血管疾病 疾病酒精使用和WP吸烟的共同发生在年轻人中相当普遍。相对于 那些不使用WP的人，WP吸烟者估计使用酒精的可能性是其他人的两倍多， 在WP吸烟之前或期间经常饮酒。令人担忧的是，香烟 吸烟文献表明，吸烟者在喝酒时吸烟更多， 很难戒烟，导致更多的尼古丁和烟草相关的有毒物质的接触。 由于WP吸烟的独特方面（例如，吸烟 烟雾可能更容易吸入，WP通常是分组吸烟）。到目前为止，没有任何研究 实验和系统地研究了酒精对WP吸烟行为的影响， 暴露于烟草相关的有毒物质，或滥用倾向。这项研究将提供必要的科学依据。 证据使用随机交叉设计，40名目前的WP吸烟者将完成两个平衡 WP吸烟阶段（酒精与安慰剂），之前有24小时的酒精戒断和12小时 戒烟会议将由一个标准的48小时洗脱期分开，WP烟草 尼古丁水平将在整个疗程中保持不变。吸烟行为的测量（抽吸地形）和 除了自我报告的指标外，还将收集急性毒物暴露（CO升高和血浆尼古丁） 滥用倾向，继续使用的意图，以及同时饮酒对使用WP的重要性。如果 酒精消费决定影响用户最初尝试WP，增加他们的意愿， 继续使用该产品，和/或使其更可口以更频繁地抽吸或进行更长/更深的抽吸， 那么同时饮酒将有助于WP依赖的开始和维持。这 创新的研究，在其共同使用酒精和WP的影响系统的检查，将提供 为可湿性粉剂的分销和销售制定有效的监管战略所需的科学基础 烟草和酒精。此外，该项目将作为一个非常宝贵的培训经验， 提供学习WP吸烟和药物相互作用的新评估的机会，同时学习 来自WP吸烟领域的领先专家，并获得跨学科合作的赞赏。