INSPPIRE to Study Pediatric Chronic Pancreatitis
INSPPIRE 研究小儿慢性胰腺炎
基本信息
- 批准号:9352341
- 负责人:
- 金额:$ 42.01万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-09-28 至 2020-08-31
- 项目状态:已结题
- 来源:
- 关键词:Abdominal PainAcuteAddressAdultAnxietyCalcium-Sensing ReceptorsCarboxypeptidaseCationsCharacteristicsChildChildhoodClinicalCognitive TherapyControl GroupsCystic FibrosisDNA Sequence AlterationDataDevelopmentDiabetes MellitusDiagnosticDiseaseDisease ProgressionEmotionalEndocrineEnrollmentEnvironmental Risk FactorEpidemiologyExocrine pancreatic insufficiencyFoundationsFrequenciesFunctional disorderGene FrequencyGene MutationGenesGeneticGenotypeGoalsGrowthHigh PrevalenceHospitalizationHybridsImpaired healthIncidenceInterdisciplinary StudyInternationalInternetKnowledgeLaboratoriesManuscriptsMeasuresMental DepressionModalityNatural HistoryNutritionalOnset of illnessOutcomePainPain managementPancreasPancreatitisPhenotypePopulationProblem behaviorProceduresPrognostic FactorRadiology SpecialtyRandomized Controlled TrialsRecurrenceRegistriesResearch PersonnelRisk FactorsRoleSerine ProteaseSerine Proteinase InhibitorsSeverity of illnessSiteTestingTrypsinogenUnited States National Institutes of HealthWorkacute pancreatitisbasebehavioral healthburden of illnesschronic painchronic pancreatitischymotrypsin Cclinical practiceclinically relevantcohortdata registryearly onsetgenetic risk factorhealth care service utilizationhealth related quality of lifeimprovedinnovationpediatric patientsprogramsprospectivepublic health relevancerepositorysocioeconomics
项目摘要
DESCRIPTION (provided by applicant): Acute pancreatitis (AP) is increasingly recognized in children, with an incidence approaching that of adults. Most children with pancreatitis have a single, mild, acute episode that resolves without complications. However, a subset of children with AP develops recurrent episodes (defined as acute recurrent pancreatitis or ARP) and some progress to chronic pancreatitis (CP). Few studies have been performed to characterize ARP and CP in children. We recognized that the lack of a well-phenotyped pediatric cohort presented a major obstacle in understanding the pathophysiology of CP and its sequelae. To address this knowledge gap, we have formed INSPPIRE (INternational Study Group of Pediatric Pancreatitis: In search for a cuRE), composed of 18 participating sites. Results from 301 pediatric patients enrolled into our study revealed a high frequency of pancreatitis-associated gene mutations and substantial disease burden in children with CP. The objective of this application is to determine the natural history of pediatric CP, identify risk factors and genetic modifiers for its onset and sequelae and develop approaches to improve clinical outcomes. The overall hypothesis of this proposal is that pediatric CP has unique characteristics that determine disease onset and sequelae. Our specific aims are: 1) Characterize pediatric CP, determine predictors of disease severity and progression from ARP to CP; 2) Define the role of genetic mutations in early onset CP and identify disease modifiers; 3) Determine the efficacy of early pain management using cognitive-behavioral intervention on pediatric CP. Our long-term goal is to develop diagnostic modalities, prognostic factors and innovative treatment approaches for pediatric ARP and CP.
描述(由申请人提供):急性胰腺炎(AP)在儿童中越来越多地被认识到,其发病率接近成人。大多数儿童胰腺炎有一个单一的,轻微的,急性发作,解决没有并发症。然而,一部分AP患儿会反复发作(定义为急性复发性胰腺炎或阿普),并在一定程度上进展为慢性胰腺炎(CP)。很少有研究被用来描述儿童的阿普和CP。我们认识到,缺乏一个良好的表型儿科队列提出了一个主要的障碍,在了解CP的病理生理及其后遗症。为了解决这一知识缺口,我们成立了INSPPIRE(国际儿童胰腺炎研究小组:寻找治愈方法),由18个参与研究中心组成。来自301名儿童患者的研究结果显示,胰腺炎相关基因突变的频率很高,CP儿童的疾病负担很大。本申请的目的是确定小儿CP的自然史,确定其发病和后遗症的风险因素和遗传修饰因子,并开发改善临床结局的方法。该建议的总体假设是,小儿CP具有决定疾病发作和后遗症的独特特征。我们的具体目标是:1)表征小儿CP,确定疾病严重程度和从阿普进展到CP的预测因素; 2)定义基因突变在早发CP中的作用,并确定疾病修饰因子; 3)确定使用认知行为干预对小儿CP进行早期疼痛管理的疗效。我们的长期目标是为小儿阿普和CP开发诊断模式、预后因素和创新治疗方法。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Aliye Uc其他文献
Aliye Uc的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Aliye Uc', 18)}}的其他基金
INSPPIRE to Study Pediatric Chronic Pancreatitis
INSPPIRE 研究小儿慢性胰腺炎
- 批准号:
9045340 - 财政年份:2015
- 资助金额:
$ 42.01万 - 项目类别:
INSPPIRE to Study Pediatric Chronic Pancreatitis
INSPPIRE 研究小儿慢性胰腺炎
- 批准号:
9237999 - 财政年份:2015
- 资助金额:
$ 42.01万 - 项目类别:
INSPPIRE to Study Pediatric Chronic Pancreatitis
INSPPIRE 研究小儿慢性胰腺炎
- 批准号:
10012208 - 财政年份:2015
- 资助金额:
$ 42.01万 - 项目类别:
INSPPIRE TO STUDY ACUTE RECURRENT AND CHRONIC PANCREATITIS IN CHILDREN
启发研究儿童急性复发性和慢性胰腺炎
- 批准号:
8541852 - 财政年份:2012
- 资助金额:
$ 42.01万 - 项目类别:
INSPPIRE TO STUDY ACUTE RECURRENT AND CHRONIC PANCREATITIS IN CHILDREN
启发研究儿童急性复发性和慢性胰腺炎
- 批准号:
8854592 - 财政年份:2012
- 资助金额:
$ 42.01万 - 项目类别:
INSPPIRE TO STUDY ACUTE RECURRENT AND CHRONIC PANCREATITIS IN CHILDREN
启发研究儿童急性复发性和慢性胰腺炎
- 批准号:
8359486 - 财政年份:2012
- 资助金额:
$ 42.01万 - 项目类别:
Characterization of Pancreatic Disease in a Novel Porcine Cystic Fibrosis Model
新型猪囊性纤维化模型中胰腺疾病的表征
- 批准号:
7697083 - 财政年份:2009
- 资助金额:
$ 42.01万 - 项目类别:
Characterization of Pancreatic Disease in a Novel Porcine Cystic Fibrosis Model
新型猪囊性纤维化模型中胰腺疾病的表征
- 批准号:
7934538 - 财政年份:2009
- 资助金额:
$ 42.01万 - 项目类别:
Regulation of heme uptake in intestinal epithelial cells
肠上皮细胞血红素摄取的调节
- 批准号:
7018313 - 财政年份:2006
- 资助金额:
$ 42.01万 - 项目类别:
Regulation of heme uptake in intestinal epithelial cells
肠上皮细胞血红素摄取的调节
- 批准号:
7190046 - 财政年份:2006
- 资助金额:
$ 42.01万 - 项目类别:
相似海外基金
Transcriptional assessment of haematopoietic differentiation to risk-stratify acute lymphoblastic leukaemia
造血分化的转录评估对急性淋巴细胞白血病的风险分层
- 批准号:
MR/Y009568/1 - 财政年份:2024
- 资助金额:
$ 42.01万 - 项目类别:
Fellowship
Combining two unique AI platforms for the discovery of novel genetic therapeutic targets & preclinical validation of synthetic biomolecules to treat Acute myeloid leukaemia (AML).
结合两个独特的人工智能平台来发现新的基因治疗靶点
- 批准号:
10090332 - 财政年份:2024
- 资助金额:
$ 42.01万 - 项目类别:
Collaborative R&D
Acute senescence: a novel host defence counteracting typhoidal Salmonella
急性衰老:对抗伤寒沙门氏菌的新型宿主防御
- 批准号:
MR/X02329X/1 - 财政年份:2024
- 资助金额:
$ 42.01万 - 项目类别:
Fellowship
Cellular Neuroinflammation in Acute Brain Injury
急性脑损伤中的细胞神经炎症
- 批准号:
MR/X021882/1 - 财政年份:2024
- 资助金额:
$ 42.01万 - 项目类别:
Research Grant
KAT2A PROTACs targetting the differentiation of blasts and leukemic stem cells for the treatment of Acute Myeloid Leukaemia
KAT2A PROTAC 靶向原始细胞和白血病干细胞的分化,用于治疗急性髓系白血病
- 批准号:
MR/X029557/1 - 财政年份:2024
- 资助金额:
$ 42.01万 - 项目类别:
Research Grant
Combining Mechanistic Modelling with Machine Learning for Diagnosis of Acute Respiratory Distress Syndrome
机械建模与机器学习相结合诊断急性呼吸窘迫综合征
- 批准号:
EP/Y003527/1 - 财政年份:2024
- 资助金额:
$ 42.01万 - 项目类别:
Research Grant
FITEAML: Functional Interrogation of Transposable Elements in Acute Myeloid Leukaemia
FITEAML:急性髓系白血病转座元件的功能研究
- 批准号:
EP/Y030338/1 - 财政年份:2024
- 资助金额:
$ 42.01万 - 项目类别:
Research Grant
STTR Phase I: Non-invasive focused ultrasound treatment to modulate the immune system for acute and chronic kidney rejection
STTR 第一期:非侵入性聚焦超声治疗调节免疫系统以治疗急性和慢性肾排斥
- 批准号:
2312694 - 财政年份:2024
- 资助金额:
$ 42.01万 - 项目类别:
Standard Grant
ロボット支援肝切除術は真に低侵襲なのか?acute phaseに着目して
机器人辅助肝切除术真的是微创吗?
- 批准号:
24K19395 - 财政年份:2024
- 资助金额:
$ 42.01万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Acute human gingivitis systems biology
人类急性牙龈炎系统生物学
- 批准号:
484000 - 财政年份:2023
- 资助金额:
$ 42.01万 - 项目类别:
Operating Grants