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INSPPIRE to Study Pediatric Chronic Pancreatitis

INSPPIRE 研究小儿慢性胰腺炎

基本信息

批准号：
10012208
负责人：
Aliye Uc
金额：
$ 27.9万
依托单位：
UNIVERSITY OF IOWA
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-28 至 2020-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10012208
关键词：
Abdominal Pain Acute Address Adult Anxiety Calcium-Sensing Receptors Carboxypeptidase Cations Characteristics Child Childhood Clinical Cognitive Therapy Control Groups Cystic Fibrosis DNA Sequence Alteration Data Development Diabetes Mellitus Diagnostic Disease Disease Progression Emotional Endocrine Enrollment Environmental Risk Factor Epidemiology Exocrine pancreatic insufficiency Foundations Frequencies Functional disorder Gene Frequency Gene Mutation Genes Genetic Genotype Goals Growth High Prevalence Hospitalization Hybrids Impaired health Incidence Interdisciplinary Study International Internet Knowledge Laboratories Manuscripts Measures Mental Depression Modality Natural History Nutritional Onset of illness Outcome Pain Pain management Pancreas Pancreatitis Pediatric cohort Phenotype Population Problem behavior Procedures Prognostic Factor Radiology Specialty Randomized Controlled Trials Recurrence Registries Research Personnel Risk Factors Role Serine Protease Serine Proteinase Inhibitors Severity of illness Site Testing Trypsinogen United States National Institutes of Health Work acute pancreatitis base behavioral health burden of illness chronic pain chronic pancreatitis chymotrypsin C clinical practice clinically relevant cohort data registry early onset genetic risk factor health care service utilization health related quality of life improved innovation pediatric patients programs prospective public health relevance repository socioeconomics

项目摘要

DESCRIPTION (provided by applicant): Acute pancreatitis (AP) is increasingly recognized in children, with an incidence approaching that of adults. Most children with pancreatitis have a single, mild, acute episode that resolves without complications. However, a subset of children with AP develops recurrent episodes (defined as acute recurrent pancreatitis or ARP) and some progress to chronic pancreatitis (CP). Few studies have been performed to characterize ARP and CP in children. We recognized that the lack of a well-phenotyped pediatric cohort presented a major obstacle in understanding the pathophysiology of CP and its sequelae. To address this knowledge gap, we have formed INSPPIRE (INternational Study Group of Pediatric Pancreatitis: In search for a cuRE), composed of 18 participating sites. Results from 301 pediatric patients enrolled into our study revealed a high frequency of pancreatitis-associated gene mutations and substantial disease burden in children with CP. The objective of this application is to determine the natural history of pediatric CP, identify risk factors and genetic modifiers for its onset and sequelae and develop approaches to improve clinical outcomes. The overall hypothesis of this proposal is that pediatric CP has unique characteristics that determine disease onset and sequelae. Our specific aims are: 1) Characterize pediatric CP, determine predictors of disease severity and progression from ARP to CP; 2) Define the role of genetic mutations in early onset CP and identify disease modifiers; 3) Determine the efficacy of early pain management using cognitive-behavioral intervention on pediatric CP. Our long-term goal is to develop diagnostic modalities, prognostic factors and innovative treatment approaches for pediatric ARP and CP.