Novel Neuromodulatory Intervention in the Rehabilitation of Pediatric Hemiparesis

小儿偏瘫康复中的新型神经调节干预

• 批准号: 9293908
• 负责人: Bernadette Therese Gillick
• 金额: $ 13.08万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-26 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9293908
• 关键词: Adult; Adverse event; Advisory Committees; Age; Applications Grants; Area; Behavior Therapy; Behavioral; Brain; Caring; Cerebral Palsy; Certification; Characteristics; Child; Childhood; Clinic; Clinical; Clinical Research; Clinical Trials; Corticospinal Tracts; Coupling; Development; Development Plans; Diagnosis; Diffusion Magnetic Resonance Imaging; Doctor of Philosophy; Electrophysiology (science); Etiology; Goals; Grant; Hand functions; Impairment; Incidence; Individual; Injury; Intervention; Knowledge; Lead; Lesion; Limb structure; Live Birth; Longevity; Manuscripts; Measures; Mentors; Motor; Motor Cortex; Motor Evoked Potentials; Motor Pathways; Neurologic; Neurologic Deficit; Neuronal Plasticity; Neurorehabilitation; Outcome; Painless; Paresis; Persons; Physiologic pulse; Preparation; Prevalence; Quality of life; Randomized; Rehabilitation Research; Rehabilitation therapy; Reporting; Research; Research Design; Research Personnel; Research Project Grants; Running; Safety; Scientist; Seizures; Serious Adverse Event; Side; Stroke; Structure; Techniques; Testing; Therapeutic Intervention; Time; Training; Transcranial magnetic stimulation; Translational Research; Translations; United States; United States National Institutes of Health; Upper Extremity; Work; base; behavioral outcome; career; career development; clinically relevant; constraint induced movement therapy; cost; design; experience; functional outcomes; group intervention; hand rehabilitation; hemiparesis; improved; improved outcome; innovation; interest; life time cost; meetings; motor control; motor function improvement; motor learning; motor recovery; neuroimaging; neuroregulation; new technology; novel; perinatal stroke; portability; predictive marker; public health relevance; repetitive transcranial magnetic stimulation; research and development; response; secondary analysis; therapy design

DESCRIPTION (provided by applicant): This project is designed to train to independence Bernadette Gillick, PhD, MSPT, PT as a rehabilitation scientist and to advance rehabilitation research in children with neurologic deficits. Dr. Gillick is a developing rehabilitation scientist with over two decades of clinical experience; with research interest both in the reorganization of the developing brain after neurologic insult or injury, and in the influence of electrophysiologic and behavioral interventions on neurorecovery. Dr. Gillick's career development objectives include expanding her knowledge of running clinical trials, mastering techniques to investigate brain reorganization and creating novel interventions designed to enhance functional motor recovery. Since last submission, Dr. Gillick has reassembled a comprehensive team of mentors and a research advisory committee to direct and guide her training. The training plan includes formal meetings with mentors, didactic training with a Certificate in Clinical Research, national meeting presentations, preparation of grant applications and manuscripts. The research project takes Dr. Gillick's work in a direction not yet studied-the use of a novel form of non-invasive brain stimulation in pediatric rehabilitation. Through her prior experience, she has learned that electrophysiologic and behavioral interventions can have a beneficial synergistic effect. She has also recently completed a safety pilot in the use of a novel form of non-invasive brain stimulation. Based on these promising findings Dr. Gillick proposes to combine interventions that, with a more thorough understanding of their effects, can conveniently reach the clinical setting and will cost less. The integration of this novel rehabilitation approach may lead to improved motor function for individuals throughout their lifetimes. The advanced support provided by the K01 career development training and research of Dr. Gillick will contribute to the NIH by producing an independent scientist able to conduct clinically relevant and translational research in pediatric neurorecovery.

描述（由申请人提供）：该项目旨在培养独立伯纳黛特吉利克博士，MSPT，PT作为康复科学家，并推进神经功能缺损儿童的康复研究。吉利克博士是一位发展中的康复科学家 具有二十多年的临床经验;研究兴趣包括神经损伤或损伤后发育中大脑的重组，以及电生理和行为干预对神经恢复的影响。Gillick博士的职业发展目标包括扩大她在开展临床试验方面的知识，掌握研究大脑重组的技术，以及创造旨在增强功能性运动恢复的新型干预措施。自上次提交以来，Gillick博士重新组建了一个全面的导师团队和一个研究咨询委员会来指导和指导她的培训。培训计划包括与导师的正式会议，临床研究证书的教学培训，国家会议演讲，赠款申请和手稿的准备。该研究项目将吉利克博士的工作引向了一个尚未研究的方向--在儿科康复中使用一种新型的非侵入性脑刺激。通过她以前的经验，她已经了解到，电生理和行为干预可以有一个有益的协同效应。她最近还完成了一项使用新型非侵入性脑刺激的安全试验。基于这些有希望的发现，Gillick博士建议将联合收割机干预措施结合起来，通过更彻底地了解其效果，可以方便地达到临床环境并且成本更低。这种新型康复方法的整合可能会改善运动功能个人的一生。Gillick博士的K 01职业发展培训和研究提供的先进支持将通过培养一名能够在儿科神经恢复方面进行临床相关和转化研究的独立科学家，为NIH做出贡献。