Modeling Core

生物学中的许多重大、突出的问题都涉及复杂的、高度交互的过程。这不是什么地方 在人类健康领域，疾病的严重程度可能取决于社会气候、个人 行为和以前的接触情况。由于生物技术的进步，现在有可能研究 复杂的生物过程达到了二三十年前无法想象的数量和功能细节的水平。 然而，这项任务非常复杂，因为这些过程本身跨越了传统 科学学科，几乎没有专门的研究人员做好充分准备单独回答这些问题。显然有一种 非常需要跨学科的研究。不太清楚的是，如何在相称的水平上实现这一点 面对我们面临的复杂问题。我们对这一挑战的解决方案的核心是建模核心。这个 建模核心是一个研究空间，是围绕核心研究员核心安排的研究人员，以及 智力交流的文化都是为了解决复杂的问题。建模核心的焦点 最初将是该中心的项目，每个项目都调查构成病毒联合- 感染。随着时间的推移，核心将扩大到包括处理新的生物医学问题的新研究人员， 开发新的方法来解决这些问题，并受益于跨学科 核心内部的动力学。我们将通过实现以下目标来实现这一愿景：1)建立核心： 人员、研究空间、文化和评估策略；2)参与综合建模 支持个人研究项目和3)通过扩展核心服务和开发 研讨会。跨学科研究解决跨越多个生物学层面的复杂问题 这需要各领域深入交流思想，才能产生真正的见解。这个 建模核心是一种创新的方式，通过提取以下三个关键特征来推动跨学科研究 这种交流：联系的共同语言，互动的空间，以及参与者的多样性。

Many of the big, outstanding problems in biology involve complex, highly interactive processes. Nowhere is this more true than in the field of human health where disease severity can depend on social climate, individual behavior and previous exposures. Because of advances in biotechnology, it is now possible to investigate complex biological processes to a level of quantitative and functional detail unimaginable 20 or 30 years ago. However, the task is greatly complicated by the fact that the processes themselves cut across traditional scientific disciplines, leaving few specialized researchers fully prepared to answer them alone. There is clearly a great need for interdisciplinary research. What is less clear is how to achieve this at a level commensurate with the complexity of the problems we face. Central to our solution to this challenge is the Modeling Core. The Modeling Core is a research space, an arrangement of researchers around a nucleus of core fellows, and a culture of intellectual exchange all geared toward solving complex problems. The focus of the Modeling Core will initially be the projects of this center, each of which investigates complex interactions that underlie viral co- infection. With time, the core will expand to include new investigators tackling new biomedical problems, developing new methodological approaches to address them, and benefiting from the interdisciplinary dynamics within the core. We will achieve this vision through realizing the following aims: 1) establish the core: the people, its research space, the culture, and a strategy for assessment, 2) engage in integrative modeling that supports individual research projects and 3) promote outreach by extending core services and developing workshops. Interdisciplinary research addresses complex problems spanning multiple levels of biological organization, and it requires a deep exchange of ideas among fields to generate genuine insights. The Modeling Core is an innovative way to power interdisciplinary research by distilling the three critical features of this exchange: a shared language for connecting, a space for interaction, and a diversity of participants.