Modeling Core

生物学中许多重大的、突出的问题都涉及复杂的、高度互动的过程。没有什么地方 在人类健康领域，疾病的严重程度可能取决于社会气候、个人 行为和之前的暴露由于生物技术的进步，现在可以研究 复杂的生物过程，达到了二三十年前无法想象的定量和功能细节的水平。 然而，这项任务非常复杂，因为这些进程本身跨越了传统的 科学学科，留下几个专门的研究人员充分准备单独回答他们。显然 对跨学科研究的巨大需求。不太清楚的是，如何在一个相称的水平上实现这一目标 我们所面临的问题的复杂性。我们解决这一挑战的核心是建模核心。的 建模核心是一个研究空间，是研究人员围绕核心研究员核心的安排，也是一个 知识交流的文化都是为了解决复杂的问题。建模核心的重点 最初将是这个中心的项目，每个项目都研究病毒协同作用的基础复杂的相互作用， 感染随着时间的推移，核心将扩大到包括新的研究人员解决新的生物医学问题， 制定新的方法来解决这些问题，并从跨学科的 核心内的动态。我们将通过实现以下目标来实现这一愿景：1）建立核心： 人，它的研究空间，文化和评估策略，2）从事综合建模 3）通过扩展核心服务和开发 工作坊.跨学科研究解决了跨越生物学多个层面的复杂问题。 它需要各领域之间深入交流思想，以产生真正的见解。的 建模核心是一种创新的方式，通过提取的三个关键特征来推动跨学科研究 这种交流：一种连接的共享语言，一个互动的空间，以及参与者的多样性。

Many of the big, outstanding problems in biology involve complex, highly interactive processes. Nowhere is this more true than in the field of human health where disease severity can depend on social climate, individual behavior and previous exposures. Because of advances in biotechnology, it is now possible to investigate complex biological processes to a level of quantitative and functional detail unimaginable 20 or 30 years ago. However, the task is greatly complicated by the fact that the processes themselves cut across traditional scientific disciplines, leaving few specialized researchers fully prepared to answer them alone. There is clearly a great need for interdisciplinary research. What is less clear is how to achieve this at a level commensurate with the complexity of the problems we face. Central to our solution to this challenge is the Modeling Core. The Modeling Core is a research space, an arrangement of researchers around a nucleus of core fellows, and a culture of intellectual exchange all geared toward solving complex problems. The focus of the Modeling Core will initially be the projects of this center, each of which investigates complex interactions that underlie viral co- infection. With time, the core will expand to include new investigators tackling new biomedical problems, developing new methodological approaches to address them, and benefiting from the interdisciplinary dynamics within the core. We will achieve this vision through realizing the following aims: 1) establish the core: the people, its research space, the culture, and a strategy for assessment, 2) engage in integrative modeling that supports individual research projects and 3) promote outreach by extending core services and developing workshops. Interdisciplinary research addresses complex problems spanning multiple levels of biological organization, and it requires a deep exchange of ideas among fields to generate genuine insights. The Modeling Core is an innovative way to power interdisciplinary research by distilling the three critical features of this exchange: a shared language for connecting, a space for interaction, and a diversity of participants.