Modeling Core

建模核心

• 批准号: 8811796
• 负责人: Michelle M Wiest
• 金额: $ 67.47万
• 依托单位: UNIVERSITY OF IDAHO
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-03-15 至 2020-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8811796
• 关键词: Address; Administrator; Area; Attention; Behavior; Biological; Biological Models; Biological Process; Biology; Biotechnology; Cell Nucleus; Communication; Communities; Complex; Consultations; Data; Discipline; Drug Formulations; Educational workshop; Ensure; Experimental Designs; Face; Faculty; Fostering; Goals; Health; Housing; Human; Individual; Interdisciplinary Study; Language; Left; Modeling; Nature; Participant; Play; Positioning Attribute; Postdoctoral Fellow; Process; Research; Research Personnel; Research Project Grants; Resources; Role; Sampling; Services; Severity of illness; Social Environment; Solutions; Specialist; Staging; Time; Training; Viral; Vision; Visit; Work; biological research; co-infection; graduate student; improved; innovation; insight; interdisciplinary collaboration; interest; meetings; member; outreach; skills; success

Many of the big, outstanding problems in biology involve complex, highly interactive processes. Nowhere is this more true than in the field of human health where disease severity can depend on social climate, individual behavior and previous exposures. Because of advances in biotechnology, it is now possible to investigate complex biological processes to a level of quantitative and functional detail unimaginable 20 or 30 years ago. However, the task is greatly complicated by the fact that the processes themselves cut across traditional scientific disciplines, leaving few specialized researchers fully prepared to answer them alone. There is clearly a great need for interdisciplinary research. What is less clear is how to achieve this at a level commensurate with the complexity of the problems we face. Central to our solution to this challenge is the Modeling Core. The Modeling Core is a research space, an arrangement of researchers around a nucleus of core fellows, and a culture of intellectual exchange all geared toward solving complex problems. The focus of the Modeling Core will initially be the projects of this center, each of which investigates complex interactions that underlie viral co- infection. With time, the core will expand to include new investigators tackling new biomedical problems, developing new methodological approaches to address them, and benefiting from the interdisciplinary dynamics within the core. We will achieve this vision through realizing the following aims: 1) establish the core: the people, its research space, the culture, and a strategy for assessment, 2) engage in integrative modeling that supports individual research projects and 3) promote outreach by extending core services and developing workshops. Interdisciplinary research addresses complex problems spanning multiple levels of biological organization, and it requires a deep exchange of ideas among fields to generate genuine insights. The Modeling Core is an innovative way to power interdisciplinary research by distilling the three critical features of this exchange: a shared language for connecting, a space for interaction, and a diversity of participants.

生物学中许多重大、突出的问题都涉及复杂、高度互动的过程。这哪里都没有 比人类健康领域更真实，在人类健康领域，疾病的严重程度可能取决于社会气候、个人 行为和之前的暴露情况。由于生物技术的进步，现在可以研究 复杂的生物过程达到了 20 或 30 年前难以想象的定量和功能细节水平。 然而，由于流程本身跨越了传统的流程​​，因此任务变得非常复杂。 科学学科，很少有专业研究人员完全准备好单独回答这些问题。明显有 非常需要跨学科研究。不太清楚的是如何在相称的水平上实现这一目标 我们面临的问题的复杂性。我们应对这一挑战的解决方案的核心是建模核心。这 建模核心是一个研究空间，研究人员围绕核心研究员的核心进行安排，以及 知识交流文化都是为了解决复杂的问题。建模核心的重点 最初将是该中心的项目，每个项目都研究病毒共存背后的复杂相互作用 感染。随着时间的推移，核心将扩大到包括解决新生物医学问题的新研究人员， 开发新的方法来解决这些问题，并从跨学科的研究中受益 核心内的动力。我们将通过实现以下目标来实现这一愿景： 1）建立核心： 人员、研究空间、文化和评估策略，2）参与综合建模 支持个人研究项目，3) 通过扩展核心服务和开发来促进外展 研讨会。跨学科研究解决跨越多个生物学层面的复杂问题 组织，并且需要领域之间深入的思想交流才能产生真正的见解。这 核心建模是一种创新方法，通过提炼跨学科研究的三个关键特征来推动跨学科研究 这种交流：用于联系的共享语言、互动的空间以及参与者的多样性。