The Relationships Between Vortices, Acoustics, and Vibration in Vocal Fold Asymmetries

声带不对称中涡流、声学和振动之间的关系

• 批准号: 9233068
• 负责人: Siddarth Mitter Khosla
• 金额: $ 57.68万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-18 至 2020-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9233068
• 关键词: Acoustics; Address; Affect; Canis familiaris; Clinical; Computer software; Consensus; Dimensions; Elasticity; Environment; Geometry; Height; Image; Implant; Inferior; Larynx; Left; Length; Lip structure; Loudness; Measurement; Measures; Mechanics; Medial; Methodology; Methods; Modeling; Operative Surgical Procedures; Oral cavity; Paralysed; Patients; Positioning Attribute; Procedures; Process; Production; Scientist; Shapes; Surface; Techniques; Tissue Model; Tissues; Velocimetries; Voice; Work; base; design; glottis; innovation; insight; operation; particle; pressure; public health relevance; rate of change; therapy design; two-dimensional; vibration; vocal cord

 DESCRIPTION (provided by applicant): Unilateral vocal fold paralysis (UVFP) can present with structural asymmetries in left-right position of the membranous folds, vocal fold height, length, tension, and arytenoid position. Surgically there is often controversy on how to restore optimal vocal function. Work in our previous R01 showed vortices form in the superior aspect of the divergent glottis during closing, and are associated with changes in the flow rate such as greater flow skewing (previously thought to be only caused by increased vocal tract inertance), and with favorable effects on loudness and intelligibility. Thus we hypothesize a better understanding of these vortices, and their effect on flow rate and acoustics, will open up a new paradigm to evaluate and design new surgical interventions for unilateral paralysis and other conditions featuring structural asymmetries. So far our findings are based on two-dimensional (2D) measurements whereas intraglottal geometry and flow rate change in all three-dimensions (3D). The extention of our technique from 2D to 3D will allow completion of the following specific aims: Specific Aim 1. Using a combination of computational and excised canine larynx models, characterize the effects of vocal tract inertance, intraglottal vortices and tissue elasticity on te medial surface dynamics of the folds, volumetric flow rate at the glottal exit, and acoustics in th following models: 1A. Excised canine larynx with relative symmetry in vocal fold length, height, and stiffness. 1B. Excised canine larynx with asymmetries in vocal fold length, height, and stiffness. 1C. Excised canine larynges that have a Thyroplasty Type I with various implant shapes and degrees of infraglottal medialization. 1D. Excised canine larynges that have Thyroplasty Type I with and without arytenoid adduction. Specific Aim 2. Volumetric flow rate will be measured directly at the glottal exit using volumetric particle imaging velocimetry and indirectly at the mouth using inverse filtering in an excised canine larynx model with a mechanical vocal tract.