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The Relationship between Vortices, Acoustics, and Vibration in Vocal Fold Assymet

声带不对称中涡流、声学和振动之间的关系

基本信息

批准号：
8525380
负责人：
Siddarth Mitter Khosla
金额：
$ 37.06万
依托单位：
UNIVERSITY OF CINCINNATI
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-18 至 2015-03-18
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8525380
关键词：
Acoustics Affect Animal Model Area Behavior Canis familiaris Cicatrix Clinical Clinical Data Complex Data Diagnostic Diagnostic Procedure Elasticity Engineering Environment Foundations Goals Grant Health Height Human Image Intervention Knowledge Larynx Lead Left Length Measures Medial Medical Methodology Modeling Modification Motion Noise Operative Surgical Procedures Outcome Paralysed Paresis Pathology Patients Phonation Polyps Positioning Attribute Principal Investigator Procedures Production Qualifying Relative (related person)Research Resolution Restaurants Severities Speed Structure Surface Techniques Technology Telephone Testing Tissues Voice Voice Disorders Work abstracting clinical decision-making clinically relevant clinically significant effective therapy improved in vivo Model innovation interest novel pressure sound vibration vocal cord

项目摘要

Project Summary/Abstract Many voice disorders feature structural vocal fold asymmetries, such as a difference in vocal fold left-right position, height, length or stiffness (e.g. unilateral vocal fold paresis and paralysis, vocal fold polyps, vocal fold scarring, etc.). When the asymmetries are mild, present therapies are effective for most patients. However, when the asymmetries are significant or multiple, outcomes are more uncertain. Such patients represent an important health problem, because the severity of their voice disorder significantly affects them physically, psychologically and economically. In any field, clinical decision-making about intervention strategies depends on a combination of clinical outcome data and the understanding of underlying mechanisms. For these patients, both because clinical data are limited and because the problems are so complex, scientific understanding of how structural asymmetries affect vocal fold vibration and voice production is particularly important. It has long been acknowledged that vortices, or areas of rotational motion, occur in the laryngeal airflow, but their relevance has not been clear. Using well-established experimental and theoretical approaches from engineering, we have found evidence that vortical structures are particularly relevant in cases of vocal fold asymmetries. In this previous work, supported by a K-8 grant to the principal investigator, our team has measured velocity fields of phonatory airflow in excised canine larynges, with particular interest in quantifying vortices. Our completed studies (Khosla et al., 2007, 2008a and 2009; Murugappan, Khosla et al., 2009) provide a supportive foundation to the overarching hypothesis of this application, which is: glottal airflow contains certain vortical structures that significantly contribute to the acoustics; and that in certain laryngeal pathologies, these vortical structures are reduced or eliminated. It is the modification and/or suppression of these vortices that contribute to abnormal voice production. Treatments that most effectively restore specific vortices will have the best voice outcomes. In order to test the central hypothesis, we propose to organize our study around the following specific aims. Excised canine and human larynges will be used for all aims. Specific Aim 1 - Using computational and validated excised hemilarynx models, characterize the effects of vortices and tissue elasticity on vocal fold vibration and acoustics. Specific Aim 2 - Vortices, tissue elasticity, vocal fold vibration and acoustics will be measured as functions of different, clinically relevant structural asymmetries. Specific Aim 3 -The change in structural asymmetries, vibratory asymmetries and acoustics will be measured after a single procedure or a combination of the following procedures for unilateral vocal fold paralysis: Thyroplasty Type 1, Adduction Arytenopexy and Cricothyroid Subluxation

项目总结/文摘