New mechanism of commensal bacteria interaction with host immunity

共生细菌如何与宿主沟通以改变免疫力，目前还不完全清楚。 在这里，我们建议描述一种以前未知的细菌之间交流的途径 真核宿主及其在介导黏膜相关免疫调节作用中的作用 共生关系。为了确定流程的性质，我们将确定参与和需求的特征 通过化学和遗传方法相结合的多种内吞途径。我们还将 在一种新的体外系统中产生并检查这些相互作用。 如果成功，我们的研究将揭示一种新的运送细菌抗原的机制 肠道中共系膜特异性T细胞的激活和/或细菌分子的传递 免疫调节。

How commensal bacteria communicate with the host to modify immunity is incompletely understood. Here we propose to characterize a previously unrecognized pathway of communication between bacteria and the eukaryotic host and its role in mediating immunomodulatory effects of mucosa-associated commensals. To identify the nature of the process we will characterize the involvement and requirement of various endocytic pathways by a combination of chemical and genetic approaches. We will also generate and examine these interactions in a novel in vitro system. If successful, our studies will uncover a novel mechanism for delivery of bacterial antigens for activation of commensal-specific T cells in the intestine, and/or for delivery of bacterial molecules for immune modulation.