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New mechanism of commensal bacteria interaction with host immunity

共生菌与宿主免疫相互作用的新机制

基本信息

批准号：
9317868
负责人：
Ivaylo Ivanov Ivanov
金额：
$ 24万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-02-01 至 2019-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9317868
关键词：
Adherence Adhesions Antigen-Presenting Cells Antigens Bacteria Bacterial Antigens Bacterial Proteins Biological Process CD4 Positive T Lymphocytes Carrier Proteins Cell membrane Cells Clathrin Collection Communication Cytoplasm Endocytic Vesicle Endocytosis Epithelial Epithelial Cells Eukaryotic Cell Feces Gastrointestinal tract structure Generations Gram-Negative Bacteria Human Immune response Immunity In Vitro Individual Inflammation Injection of therapeutic agent Intestines Mediating Mediator of activation protein Membrane Microbe Molecular Morphology Mouse Strains Mucosal Immunity Mucous Membrane Mucous body substance Nature Organism Pathway interactions Peptides Phagocytosis Physiological Play Process Production Proteins Reactive Oxygen Species Role Route Secretory Immunoglobulin A Surface Symbiosis Synapses System T-Lymphocyte Tissues Toxin Vesicle Virus antimicrobial chemical genetics commensal microbes cytokine experimental study genetic approach glycosylation immunoregulation in vivo innate immune function interest intestinal homeostasis microbial microbiota novel pathogen protein transport receptor response tool

项目摘要

How commensal bacteria communicate with the host to modify immunity is incompletely understood. Here we propose to characterize a previously unrecognized pathway of communication between bacteria and the eukaryotic host and its role in mediating immunomodulatory effects of mucosa-associated commensals. To identify the nature of the process we will characterize the involvement and requirement of various endocytic pathways by a combination of chemical and genetic approaches. We will also generate and examine these interactions in a novel in vitro system. If successful, our studies will uncover a novel mechanism for delivery of bacterial antigens for activation of commensal-specific T cells in the intestine, and/or for delivery of bacterial molecules for immune modulation.

共生细菌如何与宿主沟通以改变免疫力，目前还不完全清楚。在这里，我们建议描述一种以前未知的细菌之间交流的途径真核宿主及其在介导黏膜相关免疫调节作用中的作用共生关系。为了确定流程的性质，我们将确定参与和需求的特征通过化学和遗传方法相结合的多种内吞途径。我们还将在一种新的体外系统中产生并检查这些相互作用。如果成功，我们的研究将揭示一种新的运送细菌抗原的机制肠道中共系膜特异性T细胞的激活和/或细菌分子的传递免疫调节。