权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Magnetic Resonance Elastography of the Brain

大脑磁共振弹性成像

基本信息

批准号：
9193077
负责人：
SAMUEL PATZ
金额：
$ 22.06万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-12-15 至 2018-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9193077
关键词：
Achievement Affect Alzheimer&apos s Disease Alzheimer&apos s disease model American Appearance Area Biological Markers Blood Vessels Brain Brain Diseases Brain imaging Complement Corpus Callosum Custom Data Quality Deposition Diagnosis Diagnostic Diagnostic radiologic examination Disease Disease Progression Disease model Drug Modelings Early Diagnosis Elasticity Glioblastoma Glioma Goals Histologic Human Image Imaging technology Impaired cognition Implant Longevity Magnetic Resonance Elastography Magnetic Resonance Imaging Malignant Glioma Malignant neoplasm of brain Maps Methodology Methods Modeling Molecular Morphology Mus Neurofibrillary Tangles Noise Nude Mice Palpation Pathologic Processes Pathology Patients Perfusion Primary Brain Neoplasms Property Proteins Public Health Quality of life Recurrence Research Resolution Signal Transduction Solid Neoplasm Stem cells Structure Techniques Testing Therapeutic Intervention Time Tissues Tumor Burden Tumor Cell Invasion Vascular Proliferation Vascularization base bevacizumab brain tissue cancer type chemotherapy contrast imaging conventional therapy cytotoxic drug distribution follow-up humanized mouse imaging approach imaging modality improved longitudinal analysis molecular marker mouse model neuron loss neuropathology novel novel therapeutics outcome forecast physical property prognostic public health relevance relating to nervous system response standard of care temozolomide treatment response tumor tumor growth tumor microenvironment tumor progression viscoelasticity

项目摘要

DESCRIPTION (provided by applicant): The goal of this exploratory proposal is to validate magnetic resonance elastography (MRE) as a method that provides unique information about the progression of neuropathologies and, importantly, their response to therapy. Our team is one of the few worldwide that has established non-invasive mouse brain MRE using a customized setup with the highest spatial resolution and signal to noise ratio in the field. We hypothesize that this unique structural information (akin to a non-invasive intracranial "palpation") will allow one to follow changes in pathological processes that affect brain tissue elasticity, and even detect the appearance of "compartments" with different physical properties during disease progression, which could help to model drug distribution and tailor therapies. We propose to study two neuropathologies that produce extensive changes in neural tissue morphology and physical properties, but with vastly different origins and time course. Alzheimer's disease (AD) will be studied in Aim 1. AD is a devastating disease affecting an estimated 5.2 million Americans and is an enormous public health issue. It is an example of a neuropathology in which brain stiffness may change slowly over time due to plaque deposition, formation of protein tangles, slow neuronal death and vascular changes. Malignant brain tumors (gliomas) will be studied in Aim 2. These fast growing tumors are the most common primary brain tumors and one of the types of cancer with the worst prognosis. Gliomas are an example where local changes in stiffness are rapidly expected due to tumor growth and vascular proliferation, and where changes in stiffness can provide information about response to therapy and vascular normalization. We will study the temporal progression of both diseases using MRE and will correlate our radiographic results with well-defined histological features and molecular markers in the diseased tissues, with the goal of establishing the value of MRE as a novel, high-contrast, imaging approach with diagnostic value. Moreover, in our glioma models we will study changes in elasticity (MRE) compared to tissue perfusion (DCE-MRI) resulting from conventional chemotherapeutic approaches (cytotoxic and anti-angiogenic), which will also be correlated with histological and molecular changes after imaging. This will allow us to establish the relevance of MRE for prognostic follow-up after tumor therapy. Successful achievement of these Specific Aims will allow us to demonstrate MRE as a novel brain imaging modality that can complement MRI to provide more comprehensive information about progression and response to therapy in these and other neural diseases.

描述（由申请人提供）：本探索性提案的目的是验证磁共振弹性成像（MRE）作为一种提供有关神经病理学进展的独特信息的方法，重要的是，其对治疗的反应。我们的团队是世界上少数几个使用定制设置建立非侵入性小鼠大脑MRE的团队之一，该设置具有该领域最高的空间分辨率和信噪比。我们假设这种独特的结构信息（类似于非侵入性颅内“触诊”）将允许人们跟踪影响脑组织弹性的病理过程的变化，甚至检测疾病进展期间具有不同物理特性的“隔间”的外观，这可能有助于建模药物分布和定制治疗。我们建议研究两种神经病理学，产生广泛的神经组织形态和物理特性的变化，但有很大的不同的起源和时间过程。将在目标1中研究阿尔茨海默病（AD）。AD是一种毁灭性的疾病，影响着大约520万美国人，是一个巨大的公共卫生问题。这是一个神经病理学的例子，其中脑硬度可能会随着时间的推移缓慢变化，这是由于斑块沉积、蛋白质缠结的形成、缓慢的神经元死亡和血管变化。将在目标2中研究恶性脑肿瘤（神经胶质瘤）。这些快速生长的肿瘤是最常见的原发性脑肿瘤，也是预后最差的癌症类型之一。神经胶质瘤是一个例子，其中由于肿瘤生长和血管增殖，刚度的局部变化是迅速预期的，并且其中刚度的变化可以提供关于对治疗的反应和血管正常化的信息。我们将使用MRE研究这两种疾病的时间进展，并将我们的放射学结果与病变组织中明确的组织学特征和分子标记物相关联，目的是建立MRE作为一种新型的高对比度成像方法的诊断价值。此外，在我们的神经胶质瘤模型中，我们将研究与常规化疗方法（细胞毒性和抗血管生成）引起的组织灌注（DCE-MRI）相比的弹性变化（MRE），这也将与成像后的组织学和分子变化相关。这将使我们能够建立MRE与肿瘤治疗后预后随访的相关性。这些特定目标的成功实现将使我们能够证明MRE作为一种新型的脑成像方式，可以补充MRI，以提供有关这些和其他神经疾病的进展和治疗反应的更全面的信息。