2017 Stress Proteins in Growth, Development and Disease GRC/GRS: Maintaining proteostasis over a lifetime.

2017 生长、发育和疾病中的应激蛋白 GRC/GRS：一生中维持蛋白质稳态。

• 批准号: 9389763
• 负责人: KEVIN ANTHONY MORANO
• 金额: $ 1.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9389763
• 关键词: Address; Aging; Alzheimer' s Disease; Area; Attention; Biological Models; Biology; Biomedical Research; Biophysics; Cardiovascular Diseases; Cattle; Cell Aging; Cell Proliferation; Cellular Stress; Cellular biology; Collaborations; Country; Creutzfeldt-Jakob Syndrome; Defect; Development; Diabetes Mellitus; Disease; Ensure; Environment; Epigenetic Process; Europe; Evaluation; Gene Activation; Gene Expression; Gene Expression Regulation; Gene Mutation; Generations; Genes; Genetic Transcription; Germany; Goals; Growth and Development function; Health; Heat shock proteins; Human; Huntington Disease; Inherited; Intervention; Investigation; Link; Liver diseases; Longevity; Maine; Maintenance; Malignant Neoplasms; Metabolic Diseases; Metabolism; Modality; Molecular Chaperones; Neurodegenerative Disorders; Oral; Organism; Oxidative Stress; Parkinson Disease; Participant; Pharmacology; Physiological; Physiology; Play; Postdoctoral Fellow; Protein Biosynthesis; Proteins; Proteome; Quality Control; Radiation induced damage; Regulation; Request for Applications; Research; Research Personnel; Resort; Ribosomes; Rivers; Role; Science; Scientist; Series; Signal Transduction; Site; Stress; Structure; Students; System; Techniques; Temperature; Time; Training; Underrepresented Minority; Universities; Woman; Work; biological adaptation to stress; career; career development; collaborative environment; combat; gene product; graduate student; human disease; innovation; medical schools; meetings; polyglutamine; polypeptide; posters; prevent; prion-based; programs; protein aggregation; protein degradation; protein folding; protein function; protein misfolding; proteostasis; proteotoxicity; response; stress protein; success; symposium

PROJECT SUMMARY The cellular proteome is constantly exposed to a wide variety of proteotoxic stress conditions over a lifetime. These include external stresses, such as elevated temperatures and radiation damage as well as physiological stresses encountered during cellular proliferation and differentiation, such as oxidative stress, or challenges to protein folding caused by inherited gene mutations. A hallmark of stressed cells and organisms is the deployment of a comprehensive stress response essential for the maintenance of protein homeostasis that includes increased synthesis of molecular chaperones that aid in the folding of nascent polypeptides and prevent protein misfolding and aggregation. The protein quality control and stress protection machineries require strict signaling modalities and transcriptional programs, many of which are altered in a number of disease states, including cancer, cardiovascular disease, metabolic disease (e.g., diabetes) and liver disease. Modulation of the stress response also plays a critical role in life-span regulation and aging- related disorders such as Alzheimer's, Parkinson's, Huntington's diseases as well as prion-based disease. The 2017 Gordon Research Conference on "Stress Proteins in Growth, Development and Disease" will highlight the most recent advances in biomedical research of stress biology and stress-related diseases. This conference, the ninth in this series, will be held July 9-14 at the Sunday River Resort in Newry, Maine. The chair is Kevin Morano (UTHealth McGovern Medical School, Houston) and the vice-chair is Elke Deuerling (University of Konstanz, Germany). Special emphasis will be placed on diverse model systems that are being used to investigate stress sensing, signaling and regulation of gene expression, including epigenetic mechanisms. Cutting-edge work on spatial quality control and management of protein misfolding at the ribosome will be highlighted. Connections between compartmental protein folding status and disease will be explored. The conference's collegial and scholarly environment encourages vigorous discussions of exciting developments related to several areas of stress research. To promote the development of junior investigators in the field, a Gordon Research Seminar will be added July 8-9, immediately preceding the GRC. Additionally, we will continue recent meeting innovations of poster teaser talks, career roundtable discussions, programming focused on women investigators in the field. The formal scientific program, limited attendance and organized but informal opportunities for interaction make this meeting a preeminent conference promoting deeper understanding of the versatile roles of stress proteins in human health, aging and disease.

项目总结 细胞蛋白质组在一生中不断地暴露在各种各样的蛋白毒性应激条件下。 这些包括外部压力，如温度升高和辐射损害以及 在细胞增殖和分化过程中遇到的生理压力，如氧化应激， 或遗传基因突变对蛋白质折叠的挑战。压力过大的细胞和 生物体是一种综合的应激反应，对维持蛋白质是必不可少的 动态平衡，包括增加分子伴侣的合成，帮助新生细胞折叠 多肽和防止蛋白质错误折叠和聚集。蛋白质质量控制与应激保护 机器需要严格的信号模式和转录程序，其中许多都会在 疾病状态的数量，包括癌症、心血管疾病、代谢性疾病(如糖尿病)和 肝病。应激反应的调节在寿命调节和衰老中也发挥着关键作用。 相关的疾病，如阿尔茨海默氏症、帕金森氏症、亨廷顿病以及基于蛋白的疾病。 2017戈登研究会议的主题是《生长、发育和疾病中的应激蛋白》 重点介绍应激生物学和应激相关疾病的生物医学研究的最新进展。这 会议是本系列的第九次，将于7月9日至14日在缅因州纽里的周日河度假村举行。这个 主席是凯文·莫拉诺(休斯顿大学健康麦戈文医学院)，副主席是埃尔克·杜尔林 (德国康斯坦茨大学)。将特别强调不同的模型系统，这些系统正在 用于研究压力感应、信号和基因表达的调节，包括表观遗传学 机制。在空间质量控制和蛋白质错误折叠管理方面的前沿工作 核糖体将突出显示。隔室蛋白折叠状态和疾病之间的联系将是 探索过了。会议的大学和学术环境鼓励对激动人心的 与压力研究的几个领域相关的发展。促进初级侦查员队伍建设 在这一领域，戈登研究研讨会将于7月8日至9日在GRC之前增加。另外， 我们将继续最近的会议创新，海报预告片演讲，职业圆桌讨论， 方案的重点是该领域的女调查员。正式的科学计划，有限的出席人数 有组织但非正式的互动机会使这次会议成为一次卓越的会议，以促进 更深入地了解应激蛋白在人类健康、衰老和疾病中的多种作用。