2017 Stress Proteins in Growth, Development and Disease GRC/GRS: Maintaining proteostasis over a lifetime.

2017 生长、发育和疾病中的应激蛋白 GRC/GRS：一生中维持蛋白质稳态。

• 批准号: 9389763
• 负责人: KEVIN ANTHONY MORANO
• 金额: $ 1.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9389763
• 关键词: Address; Aging; Alzheimer' s Disease; Area; Attention; Biological Models; Biology; Biomedical Research; Biophysics; Cardiovascular Diseases; Cattle; Cell Aging; Cell Proliferation; Cellular Stress; Cellular biology; Collaborations; Country; Creutzfeldt-Jakob Syndrome; Defect; Development; Diabetes Mellitus; Disease; Ensure; Environment; Epigenetic Process; Europe; Evaluation; Gene Activation; Gene Expression; Gene Expression Regulation; Gene Mutation; Generations; Genes; Genetic Transcription; Germany; Goals; Growth and Development function; Health; Heat shock proteins; Human; Huntington Disease; Inherited; Intervention; Investigation; Link; Liver diseases; Longevity; Maine; Maintenance; Malignant Neoplasms; Metabolic Diseases; Metabolism; Modality; Molecular Chaperones; Neurodegenerative Disorders; Oral; Organism; Oxidative Stress; Parkinson Disease; Participant; Pharmacology; Physiological; Physiology; Play; Postdoctoral Fellow; Protein Biosynthesis; Proteins; Proteome; Quality Control; Radiation induced damage; Regulation; Request for Applications; Research; Research Personnel; Resort; Ribosomes; Rivers; Role; Science; Scientist; Series; Signal Transduction; Site; Stress; Structure; Students; System; Techniques; Temperature; Time; Training; Underrepresented Minority; Universities; Woman; Work; biological adaptation to stress; career; career development; collaborative environment; combat; gene product; graduate student; human disease; innovation; medical schools; meetings; polyglutamine; polypeptide; posters; prevent; prion-based; programs; protein aggregation; protein degradation; protein folding; protein function; protein misfolding; proteostasis; proteotoxicity; response; stress protein; success; symposium

PROJECT SUMMARY The cellular proteome is constantly exposed to a wide variety of proteotoxic stress conditions over a lifetime. These include external stresses, such as elevated temperatures and radiation damage as well as physiological stresses encountered during cellular proliferation and differentiation, such as oxidative stress, or challenges to protein folding caused by inherited gene mutations. A hallmark of stressed cells and organisms is the deployment of a comprehensive stress response essential for the maintenance of protein homeostasis that includes increased synthesis of molecular chaperones that aid in the folding of nascent polypeptides and prevent protein misfolding and aggregation. The protein quality control and stress protection machineries require strict signaling modalities and transcriptional programs, many of which are altered in a number of disease states, including cancer, cardiovascular disease, metabolic disease (e.g., diabetes) and liver disease. Modulation of the stress response also plays a critical role in life-span regulation and aging- related disorders such as Alzheimer's, Parkinson's, Huntington's diseases as well as prion-based disease. The 2017 Gordon Research Conference on "Stress Proteins in Growth, Development and Disease" will highlight the most recent advances in biomedical research of stress biology and stress-related diseases. This conference, the ninth in this series, will be held July 9-14 at the Sunday River Resort in Newry, Maine. The chair is Kevin Morano (UTHealth McGovern Medical School, Houston) and the vice-chair is Elke Deuerling (University of Konstanz, Germany). Special emphasis will be placed on diverse model systems that are being used to investigate stress sensing, signaling and regulation of gene expression, including epigenetic mechanisms. Cutting-edge work on spatial quality control and management of protein misfolding at the ribosome will be highlighted. Connections between compartmental protein folding status and disease will be explored. The conference's collegial and scholarly environment encourages vigorous discussions of exciting developments related to several areas of stress research. To promote the development of junior investigators in the field, a Gordon Research Seminar will be added July 8-9, immediately preceding the GRC. Additionally, we will continue recent meeting innovations of poster teaser talks, career roundtable discussions, programming focused on women investigators in the field. The formal scientific program, limited attendance and organized but informal opportunities for interaction make this meeting a preeminent conference promoting deeper understanding of the versatile roles of stress proteins in human health, aging and disease.

项目概要 细胞蛋白质组在一生中不断暴露于各种蛋白毒性应激条件下。 这些包括外部应力，例如高温和辐射损伤以及 细胞增殖和分化过程中遇到的生理应激，例如氧化应激， 或由遗传基因突变引起的蛋白质折叠挑战。应激细胞的标志和 生物体部署全面的应激反应对于维持蛋白质至关重要 稳态，包括增加有助于新生折叠的分子伴侣的合成 多肽并防止蛋白质错误折叠和聚集。蛋白质质量控​​制和应激保护 机器需要严格的信号传导模式和转录程序，其中许多在 疾病状态的数量，包括癌症、心血管疾病、代谢疾病（例如糖尿病）和 肝脏疾病。应激反应的调节在寿命调节和衰老方面也起着至关重要的作用 相关疾病，如阿尔茨海默病、帕金森病、亨廷顿病以及朊病毒疾病。 2017年戈登研究会议“生长、发育和疾病中的应激蛋白”将 重点介绍应激生物学和应激相关疾病的生物医学研究的最新进展。这 这是该系列会议的第九次会议，将于 7 月 9 日至 14 日在缅因州纽里的周日河度假村举行。这 主席是 Kevin Morano（UTHealth 麦戈文医学院，休斯顿），副主席是 Elke Deuerling （德国康斯坦茨大学）。将特别强调正在开发的各种模型系统 用于研究基因表达的应激感知、信号传导和调控，包括表观遗传 机制。蛋白质错误折叠空间质量控制和管理的前沿工作 核糖体将被突出显示。区室蛋白质折叠状态与疾病之间的联系将是 探索过。会议的学术和学术环境鼓励对令人兴奋的问题进行激烈的讨论 与压力研究的几个领域相关的进展。促进初级研究者的发展 在现场，戈登研究研讨会将于 7 月 8 日至 9 日在 GRC 之前举行。此外， 我们将继续近期的会议创新，包括海报预告讲座、职业圆桌讨论、 规划的重点是该领域的女性调查员。正式的科学计划，有限的出席人数 以及有组织但非正式的互动机会使本次会议成为一次卓越的会议，促进 更深入地了解应激蛋白在人类健康、衰老和疾病中的多种作用。