Research Coordinating Unit for Testing Multi-Level Interventions to Improve Blood Pressure Control in Minority Racial/Ethnic, Low Socioeconomic Status, and/or Rural Populations

 描述(由申请人提供)：Westat很高兴根据RFA-HL-15-031申请担任研究协调单位(RCU)，以支持高血压差异减少计划伙伴关系(HDRPP)的目标以及本协议所要求的行政、沟通和研究活动。作为这一研究伙伴关系的成员，RCU将与UH2/UH3调查人员、计划工作人员和计划指导委员会(PSC)合作，建立和培育一种合作和富有成效的学习文化，致力于满足计划的规划和实施里程碑，在可行的情况下协调设计元素，并向利益相关者和消费者生成和分享相关证据。Westat的临床试验领域拥有超过25年的协调和执行联邦资助的与患者、医疗保健提供者和政策制定者相关的临床研究的经验。我们一直是许多大型、多地点和多学科临床研究项目的协调中心，涉及广泛的健康和疾病重点领域。Westat推荐的RCU团队提供强大的后勤和技术能力，以及一支主题专家(SME)团队，他们深入了解PCORI的使命和目标，了解以患者为中心的结果研究(PCOR)、比较有效性研究(CER)以及患者和利益相关者参与原则，并了解以社区为基础的高血压管理的复杂性和挑战。提议的首席调查员Paula Darby Lipman博士，与初级保健实践研究网络(PBRN)进行干预研究，在PCOR的基础设施建设项目上合作，目前是NHLBI务实试验评估和管理协调中心的PI。与她一起工作的还有Westat的预防医学专家(Marget Krauss医学博士)、PCOR和利益相关者参与方法专家(Jennifer Huang博士)、健康差距和少数群体健康专家(Brenda Leath医学博士)，以及经验丰富的项目经理Lauren Laimon女士。RCU的愿景是支持HDRPP的目标，即通过协调调查人员、PSC、PCORI和国家卫生研究院之间的研究和沟通相关活动，缩小高危人群对高血压的认识、诊断、治疗和结果方面的差距。

 DESCRIPTION (provided by applicant): Westat is pleased to apply in response to RFA-HL-15-031 to serve as the Research Coordinating Unit (RCU) in support of the Hypertension Disparities Reduction Program Partnership (HDRPP) goals and the administrative, communication, and research activities required under this agreement. As a member of this research partnership, the RCU will work with UH2/UH3 investigators, program staff, and the Program Steering Committee (PSC) to establish and nurture a cooperative and productive learning culture committed to meeting the program's planning and implementation milestones, harmonizing design elements where feasible, and generating and sharing relevant evidence to stakeholders and consumers. The Clinical Trials Area of Westat has over 25 years' experience coordinating and conducting federally sponsored clinical research relevant to patients, healthcare providers, and policymakers. We have served as the coordinating center for many large, multi-site, and multidisciplinary clinical research programs across a broad range of health and disease focus areas. Westat's proposed RCU team offers strong logistical and technical capabilities, as well as a team of subject matter experts (SMEs) with in-depth appreciation of PCORI's mission and goals, knowledge of patient- centered outcomes research (PCOR), comparative effectiveness research (CER), and patient and stakeholder engagement principles, and an understanding of the complexity and challenges of community-based management of hypertension. Proposed Principal Investigator (PI) Paula Darby Lipman, PhD, has conducted intervention research with primary care practice-based research networks (PBRNs), collaborated on infrastructure building projects in PCOR, and is currently PI for the NHLBI Pragmatic Trials Evaluation and Administration Coordinating Center. She is joined by Westat experts in preventive medicine (Margot Krauss, MD), PCOR and stakeholder engagement methodology (Jennifer Huang, PhD), and health disparities and minority health (Brenda Leath, MHSA), and an experienced project manager, Ms. Lauren Laimon. The vision for the RCU is to support the HDRPP goal of reducing the gap in hypertension awareness, diagnosis, treatment, and outcomes among high-risk populations through the coordination of research- and communications- related activities between and among the investigators, the PSC, PCORI, and the National Institutes of Health.