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MRI-Guided Irreversible Electroporation Ablation for Liver Tumors

MRI-Guided Irreversible Electroporation Ablation for Liver Tumors
MRI 引导不可逆电穿孔消融治疗肝脏肿瘤
批准号:
9314545
负责人:
Zhuoli Zhang
金额:
$34.72万
依托单位国家:
美国
项目类别:
财政年份:
2015
资助国家:
美国
项目状态:
已结题
起止时间:
2015-07-01 至 2019-06-30

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英文摘要
 DESCRIPTION (provided by applicant): Irreversible electroporation (IRE) is a powerful new ablation technology that overcomes many of the primary limitations of thermal ablation approaches. However, for accurate, early prediction of treatment response, follow-up imaging methods must permit in vivo discrimination of irreversibly electroporated tissues from adjacent inadequately treated, reversibly electroporated tissues. Our most recent studies have demonstrated that quantitative MRI methods can detect electroporation-induced alterations to the cell membrane in both tumor and normal tissues. We will develop a powerful new MRI-guided IRE approach permitting a) pre- procedural planning to predict IRE ablation volumes, b) intra-procedural monitoring of tissue response and c) early post-procedural identification of inadequately treated (reversibly electroporated) tissues. Our ultimate goal is to achieve complete treatment of targeted tumors while avoiding excessive damage to adjacent liver tissues. The proposed pre-clinical project will address the following Specific Aims in a well-established rabbit liver tumor model: Specific Aim 1: To develop pre-procedural planning techniques to more accurately predict IRE ablation volumes. Specific Aim 2: To develop intra-procedural imaging methods for immediate functional monitoring of tumor tissue response. Specific Aim 3: To develop post-procedural imaging methods for early identification of inadequately treated, reversibly electroporated tumor tissues.
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MRI-Guided Dendritic-Cell-Based Vaccine Immunotherapy for Pancreatic Cancer
  • 批准号:
    10336295
  • 项目类别:
  • 资助金额:
    $34.28万
  • 财政年份:
    2021
  • 负责人:
    Zhuoli Zhang
  • 依托单位:
MRI-Guided Dendritic-Cell-Based Vaccine Immunotherapy for Pancreatic Cancer
MRI-Guided Dendritic-Cell-Based Vaccine Immunotherapy for Pancreatic Cancer
MRI-Guided Dendritic-Cell-Based Vaccine Immunotherapy for Pancreatic Cancer
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