权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Restoring oscillations underlying adaptive control in schizophrenia with direct current

用直流电恢复精神分裂症自适应控制的振荡

基本信息

批准号：
9344699
负责人：
SOHEE PARK
金额：
$ 39.23万
依托单位：
VANDERBILT UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-07 至 2021-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9344699
关键词：
Adaptive Behaviors Affect Anodes Area Attention Behavior Behavioral Brain Brain Diseases Brain region Cognitive Cognitive deficits Conflict (Psychology)Coupled Data Disease Electric Stimulation Electrical Stimulation of the Brain Electroencephalogram Exhibits Failure Feedback Frequencies Functional disorder Goals Gold Habits Hallucinations Health Care Costs Impaired cognition Impairment Individual Intervention Lead Link Measurement Measures Medial Methods Modeling Neurons Neurosciences Occupational Occupations Outcome Patients Pattern Pharmaceutical Preparations Phase Population Process Protocols documentation Public Health Research Schizophrenia Sensory Signal Transduction Stimulus System Techniques Time Translating United States Work behavior measurement cognitive ability cognitive control cognitive function cognitive process cost disability flexibility frontal lobe improved insight prevent programs psychotic symptoms response restoration social success tool

项目摘要

PROJECT SUMMARY Schizophrenia is a severe and debilitating disorder that affects about 51 billion people worldwide, and costs more than $60 billion annually in United States (Salomon and al., 2013). Despite the more spectacular psychotic symptoms of schizophrenia (e.g., hallucinations), it is the cognitive impairments that largely drive the poor outcomes from the illness, such as preventing patients from keeping jobs, due to the inability of medications to effectively treat these cognitive impairments (Gold and Weinberger, 1995; Green, 1996; Elvevag and Goldberg, 2000). Failures of adaptive control are a hallmark of the cognitive impairments in schizophrenia. Adaptive control allows healthy individuals to follow rules and to override compelling competing responses. Impairments of adaptive control result in errors and an inability to change following negative feedback. In systems neuroscience, a growing body of evidence demonstrates that adaptive control processes are supported by oscillatory activity in the healthy brain (Luu et al., 2003; Wang et al., 2005; Cavanagh et al., 2009; van Driel et al., 2012; Anguera et al., 2013; Narayanan et al., 2013; Cavanagh and Frank, 2014), and that certain patterns of oscillatory dynamics might be useful for understanding the cognitive impairments in schizophrenia (Ford and Mathalon, 2008; Uhlhaas and Singer, 2010; Lesh et al., 2011). In this project, we propose to use a causal neuroscientific technique, noninvasive electrical brain stimulation, combined with measurements of electroencephalographic oscillations to determine whether modifying certain oscillatory rhythms in patients with schizophrenia can improve cognitive abilities. Our preliminary data are highly encouraging and indicate that we can selectively manipulate the phase of oscillatory activity and cause improvements in the adaptive control exhibited by patients with schizophrenia. The goals of our research are to use the tools and insights from basic neuroscience to gain a deeper understanding the cognitive impairments in schizophrenia, and achieve concrete translational progress toward a non-pharmacological therapy for boosting cognitive function in schizophrenia. 1

项目总结