Leveraging Established Fetal Primate Models to Expedite ZIKV Investigations

利用已建立的胎儿灵长类动物模型加快 ZIKV 研究

基本信息

  • 批准号:
    9543066
  • 负责人:
  • 金额:
    $ 10.04万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-08-01 至 2018-07-31
  • 项目状态:
    已结题

项目摘要

SUMMARY / ABSTRACT The outbreak of Zika virus (ZIKV) and the alarming rise in fetal brain malformations highlight ZIKV as an urgent public health concern. ZIKV has recently met Shephard's criteria for teratogenic classification because of the brain anomalies reported. This application addresses the direct relationship between ZIKV infection and fetal brain development using our established fetal primate model of intrauterine pathogenesis. The studies outlined in this application leverage our prior discoveries and collaborative investigations on neural precursor cell function in relation to microglia in the fetal primate brain, and our expertise in primate development, imaging, virology, and immunology. Our track record and experienced team provides the means to pursue the goals of this proposal—understanding the mechanism(s) of ZIKV teratogenesis—and the steps necessary to progress to studies focused on interventions. Our goal is to determine how ZIKV alters cortical development by capitalizing on our team's essential expertise and research experiences to address this urgent public health concern rapidly and effectively through the following Specific Aims: (1) Define the impact of fetal ZIKV on neural precursor cells and cortical development, and (2) Determine the impact of fetal ZIKV infection on fetal and maternal inflammation and assess if inflammation is predictive of abnormalities in cortical development. These studies will provide new insights into the underpinnings of ZIKV teratogenesis in a primate model with similar neurodevelopmental features when compared to humans, and by efficiently leveraging an existing primate model of fetal viral infection. Overall, these investigations focus on fetal developmental outcomes associated with direct ZIKV infection and will provide the necessary mechanistic understanding and outcome metrics to assess intervention strategies that protect the fetus and newborn from the devastating consequences of ZIKV infection and congenital disease.
摘要/摘要

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Peter A Barry其他文献

Breast cancer outcomes in women with ovarian cancer and a pathogenic germline emBRCA/em mutation
患有卵巢癌和致病性种系 BRCA 突变的女性的乳腺癌结局
  • DOI:
    10.1016/j.ejso.2024.109380
  • 发表时间:
    2025-03-01
  • 期刊:
  • 影响因子:
    2.900
  • 作者:
    Quratul Ain;Rachel L O'Connell;Parinita Swarnkar;Terri McVeigh;Angela George;Marios K Tasoulis;Gerald PH Gui;Jennifer Wiggins;Aadil A Khan;Katherine DC Krupa;Peter A Barry;Susana Banerjee;Jennifer E Rusby
  • 通讯作者:
    Jennifer E Rusby

Peter A Barry的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Peter A Barry', 18)}}的其他基金

Immunologic and virologic determinants of congenital Cytomegalovirus transmission and disease in rhesus monkeys
恒河猴先天性巨细胞病毒传播和疾病的免疫学和病毒学决定因素
  • 批准号:
    9982176
  • 财政年份:
    2019
  • 资助金额:
    $ 10.04万
  • 项目类别:
Immunologic and virologic determinants of congenital Cytomegalovirus transmission and disease in rhesus monkeys
恒河猴先天性巨细胞病毒传播和疾病的免疫学和病毒学决定因素
  • 批准号:
    10215778
  • 财政年份:
    2019
  • 资助金额:
    $ 10.04万
  • 项目类别:
Role of reservoir composition and T cell immunity in HIV rebound kinetics
储库成分和 T 细胞免疫在 HIV 反弹动力学中的作用
  • 批准号:
    9332144
  • 财政年份:
    2017
  • 资助金额:
    $ 10.04万
  • 项目类别:
CMV-vectored Vaccine Approaches to Induce Protective Antibodies to HIV-1 Env
CMV 载体疫苗诱导 HIV-1 包膜保护性抗体的方法
  • 批准号:
    9415296
  • 财政年份:
    2017
  • 资助金额:
    $ 10.04万
  • 项目类别:
Role of reservoir composition and T cell immunity in HIV rebound kinetics
储库成分和 T 细胞免疫在 HIV 反弹动力学中的作用
  • 批准号:
    9530523
  • 财政年份:
    2017
  • 资助金额:
    $ 10.04万
  • 项目类别:
Impact of chronic viral infections and altered microbiota on HIV vaccine efficacy
慢性病毒感染和微生物群改变对艾滋病毒疫苗功效的影响
  • 批准号:
    9078765
  • 财政年份:
    2015
  • 资助金额:
    $ 10.04万
  • 项目类别:
HCMV Vaccine produced from BAC-MVA that Blocks Epithelial and Fibroblast Entry
由 BAC-MVA 生产的 HCMV 疫苗可阻止上皮细胞和成纤维细胞进入
  • 批准号:
    9054798
  • 财政年份:
    2013
  • 资助金额:
    $ 10.04万
  • 项目类别:
HCMV Vaccine produced from BAC-MVA that Blocks Epithelial and Fibroblast Entry
由 BAC-MVA 生产的 HCMV 疫苗可阻止上皮细胞和成纤维细胞进入
  • 批准号:
    8590524
  • 财政年份:
    2013
  • 资助金额:
    $ 10.04万
  • 项目类别:
HCMV Vaccine produced from BAC-MVA that Blocks Epithelial and Fibroblast Entry
由 BAC-MVA 生产的 HCMV 疫苗可阻止上皮细胞和成纤维细胞进入
  • 批准号:
    8839199
  • 财政年份:
    2013
  • 资助金额:
    $ 10.04万
  • 项目类别:
HCMV Vaccine produced from BAC-MVA that Blocks Epithelial and Fibroblast Entry
由 BAC-MVA 生产的 HCMV 疫苗可阻止上皮细胞和成纤维细胞进入
  • 批准号:
    8660624
  • 财政年份:
    2013
  • 资助金额:
    $ 10.04万
  • 项目类别:

相似海外基金

Mechanisms that underlie the life/death decisions in a cell that activated apoptotic caspases
细胞中激活凋亡半胱天冬酶的生/死决策的机制
  • 批准号:
    10607815
  • 财政年份:
    2023
  • 资助金额:
    $ 10.04万
  • 项目类别:
Nuclear and chromatin aberrations during non-apoptotic cell death in C. elegans and mammals
线虫和哺乳动物非凋亡细胞死亡过程中的核和染色质畸变
  • 批准号:
    10723868
  • 财政年份:
    2023
  • 资助金额:
    $ 10.04万
  • 项目类别:
Non-apoptotic functions of caspase-3 in neural development
Caspase-3在神经发育中的非凋亡功能
  • 批准号:
    10862033
  • 财政年份:
    2023
  • 资助金额:
    $ 10.04万
  • 项目类别:
Apoptotic Donor Leukocytes to Promote Kidney Transplant Tolerance
凋亡供体白细胞促进肾移植耐受
  • 批准号:
    10622209
  • 财政年份:
    2023
  • 资助金额:
    $ 10.04万
  • 项目类别:
Design of apoptotic cell mimetic anti-inflammatory polymers for the treatment of cytokine storm
用于治疗细胞因子风暴的模拟凋亡细胞抗炎聚合物的设计
  • 批准号:
    22H03963
  • 财政年份:
    2022
  • 资助金额:
    $ 10.04万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Identifying the mechanisms behind non-apoptotic functions of mitochondrial matrix-localized MCL-1
确定线粒体基质定位的 MCL-1 非凋亡功能背后的机制
  • 批准号:
    10537709
  • 财政年份:
    2022
  • 资助金额:
    $ 10.04万
  • 项目类别:
Environmental Carcinogens Induce Minority MOMP to Initiate Carcinogenesis in Lung Cancer and Mesothelioma whileMaintaining Apoptotic Resistance via Mcl-1
环境致癌物诱导少数 MOMP 引发肺癌和间皮瘤的癌变,同时通过 Mcl-1 维持细胞凋亡抵抗
  • 批准号:
    10356565
  • 财政年份:
    2022
  • 资助金额:
    $ 10.04万
  • 项目类别:
Targeting apoptotic cells to enhance radiotherapy
靶向凋亡细胞以增强放射治疗
  • 批准号:
    10708827
  • 财政年份:
    2022
  • 资助金额:
    $ 10.04万
  • 项目类别:
Activation of non-apoptotic cell death by the DNA damage response
DNA 损伤反应激活非凋亡细胞死亡
  • 批准号:
    10388929
  • 财政年份:
    2022
  • 资助金额:
    $ 10.04万
  • 项目类别:
Role of natural immunity to self apoptotic exosomes in maintaining immune homeostasis
对自凋亡外泌体的自然免疫在维持免疫稳态中的作用
  • 批准号:
    RGPIN-2021-03004
  • 财政年份:
    2022
  • 资助金额:
    $ 10.04万
  • 项目类别:
    Discovery Grants Program - Individual
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了