Colorado Adoption/Twin Study of Lifespan behavioral development & cognitive aging (CATSLife)

科罗拉多州收养/双胞胎终身行为发展研究

• 批准号: 9530326
• 负责人: CHANDRA A REYNOLDS
• 金额: $ 4.75万
• 依托单位: UNIVERSITY OF CALIFORNIA RIVERSIDE
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-01 至 2020-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9530326
• 关键词: Adolescence; Adolescent; Adopted; Adoption; Adult; Affect; Age; Alcohol or Other Drugs use; Alcohols; Alzheimer' s disease risk; Behavioral; Biochemical; Biochemical Markers; Biological; Biological Markers; Birth; Blood; Blood Pressure; Brain; Brain-Derived Neurotrophic Factor; Cereals; Child Development; Childhood; Cognition; Cognitive; Cognitive aging; Colorado; Conceptions; Data; Development; Elderly; Environment; Environmental Risk Factor; Etiology; Functional Magnetic Resonance Imaging; Genes; Genetic; Genetic Risk; Genetic Variation; Genetic study; Goals; Growth; Hand Strength; Health; Health Services; Health behavior; Health education; Hippocampus (Brain); Impaired cognition; Individual; Individual Differences; International; Intervention; Leisure Activities; Life; Life Cycle Stages; Lipids; Longevity; Longitudinal Studies; Longitudinal prospective study; Maintenance; Maps; Measures; Modeling; Nature; Neighborhoods; Outcome; Parents; Participant; Pathway interactions; Pattern; Performance; Phenotype; Physical Function; Physical activity; Positioning Attribute; Research; Serum; Short-Term Memory; Siblings; Signal Transduction; Smoking; Speed; Synaptic plasticity; Testing; Twin Multiple Birth; Twin Studies; Variant; age related cognitive change; base; behavioral study; cognitive ability; cognitive change; cognitive development; cognitive function; cognitive performance; design; developmental genetics; early adolescence; early childhood; emerging adult; executive function; frontal lobe; improved; infancy; innovation; middle age; middle childhood; offspring; physical conditioning; proband; prospective; public health relevance; pulmonary function; skills; social; stem

DESCRIPTION (provided by applicant): Early influences may accumulate over the life course to impact how well we age. However, relatively little is known about the developmental etiologies of individual differences in age- related cognitive change. Thus, the primary objective of the proposed research is to assess the unique saliency of early childhood factors to adult cognitive maintenance and change versus proximal influences and innovations (genetic and environmental) that emerge across development. We will leverage the strengths of two internationally renowned studies of behavioral development, the Colorado Adoption Project (CAP) and the Longitudinal Twin Study (LTS), each with decades of previously collected cognitive and behavioral data spanning infancy to early adulthood, and conduct a new assessment of 776 adoptive and non-adoptive probands and siblings and 824 twins, ranging in age from 28-38 years. The resulting Colorado Adoption/Twin Study of Lifespan behavioral development and cognitive aging (CATSLife) will be the first prospective longitudinal study of the etiologies of behavioral and cognitive changes during the transition to middle adulthood. The aims are to: conduct a genetically sensitive study of individual differences in behavioral and cognitive change at the cusp of middle adulthood, in 1600 participants studied almost yearly from birth to early adulthood; map individual differences in growth and maintenance of cognitive abilities; evaluate and trace measured physical factors and health behaviors, biochemical markers and measured genetic pathways important to sustaining cognitive performance; and track measured environmental factors that might decrease, sustain or boost cognitive performance. The CATSLife will include expanded assessment of cognitive performance, physical functioning and health behaviors, gene pathways, including measured genetic variation in lipid, synaptic plasticity and cell-signaling paths (based on chip array variants), biochemical markers (e.g., serum lipids), and environmental measures (e.g., engagement in leisure activities). We will assess etiologies of changes in physical health and cognitive functioning, and test whether associations across domains change with age due to changes in genetic variation or self-selection of environments. Measured gene pathway sets, and environmental measures, including engagement in leisure activities and neighborhood-level variables, will be evaluated as potential factors underlying dynamics of genetic variation or environmental selection. Thus, the CATSLife will provide an unparalleled opportunity to assess prospectively the etiologies of cognitive change, and test the saliency of early childhood versus proximal influences on the genesis of cognitive decline.

描述（由申请人提供）：早期影响可能会在生命过程中积累，以影响我们的年龄。然而，对年龄相关认知变化的个体差异的发育病因学知之甚少。因此，拟议的研究的主要目标是评估独特的显着性的幼儿因素，以成人认知的维护和变化与近端的影响和创新（遗传和环境），出现在整个发展。我们将利用两项国际知名的行为发展研究的优势，科罗拉多收养项目（CAP）和纵向双胞胎研究（LTS），每个研究都有几十年以前收集的从婴儿期到成年早期的认知和行为数据，并对776名收养和非收养先证者和兄弟姐妹以及824名双胞胎进行新的评估，年龄从28岁到38岁不等。由此产生的科罗拉多终身行为发展和认知老化的收养/双胞胎研究（CATSLife）将是第一个前瞻性的纵向研究的病因学的行为和认知的变化，在过渡到中年。其目的是：对1600名参与者进行从出生到成年早期几乎每年一次的行为和认知变化的个体差异的遗传敏感性研究;绘制认知能力增长和维持的个体差异;评估和跟踪测量的身体因素和健康行为、生物化学标志物和测量的对维持认知能力重要的遗传途径;并跟踪可能降低、维持或提高认知表现的测量环境因素。CATSLife将包括对认知能力、身体功能和健康行为、基因通路（包括测量的脂质遗传变异）、突触可塑性和细胞信号通路（基于芯片阵列变体）、生化标志物（例如，血清脂质），和环境测量（例如，参与休闲活动）。我们将评估身体健康和认知功能变化的病因， 测试跨领域的关联是否因遗传变异或环境自我选择的变化而随年龄变化。测量的基因通路集，和环境措施，包括参与休闲活动和邻里水平的变量，将作为潜在的遗传变异或环境选择的动态因素进行评估。因此，CATSLife将提供一个无与伦比的机会，以前瞻性地评估认知变化的病因，并测试幼儿期的显着性与近端影响认知下降的起源。