Optical Aberration and Visual Performance for Highly Aberrated Eyes

 描述（由申请人提供）：本次竞争性更新的目标是将波前引导巩膜接触镜的实验室研究转化为高度像差眼睛的临床解决方案，将视网膜图像质量恢复到正常或优于正常水平。这将通过识别和消除目前使临床翻译复杂化的障碍来实现。这一目标的完成将使研究小组能够检验以下假设：1）A 成熟视觉系统由于高阶像差的升高，现在习惯性地经历不良视网膜图像质量的人（在形成年龄期间经历了良好的视网膜图像质量）将随着时间的推移适应回到正常水平的视觉表现（视敏度、作为字母大小和立体视敏度的函数的对比敏感度）;和2）与临床上可用的非波前引导的校正相比，由波前引导的校正提供的正常或优于正常的视网膜图像质量改善了具有高度像差眼睛的患者的生活质量。

 DESCRIPTION (provided by applicant): The goal of this competitive renewal is to translate laboratory research on wavefront-guided scleral contact lenses into a clinical solution for highly aberrated eyes that restores retinal image quality to normal or better than normal levels. This will be accomplished by identifying and removing barriers that currently complicate clinical translation. Completion of this goal will allow the research team to test the hypotheses that: 1) A mature visual system (having experienced good retinal image quality during the formative years) that is now habitually experiencing poor retinal image quality due to elevated higher order aberrations will, with time, adapt back to normal levels of visual performance (visual acuity, contrast sensitivity as a function of letter size and stereo-acuity); and 2) normal or better than normal retinal image quality provided by wavefront guided corrections improves quality of life in patients with highly aberrated eyes compared to clinically available non-wavefront guided corrections.