ABERRATIONS OF EYES IN NORMAL AND CLINICAL POPULATIONS

描述：（改编自申请人摘要。）评价 正常和异常角膜的光学质量受到限制 主要用于测量视觉性能 灵敏度、敏锐度和眩光。 虽然这些措施反映了 角膜光学质量，它们不容易反映光学质量的变化。 性能作为瞳孔大小的函数，也不提供具体的洞察力， 导致各种光学改善或缺陷。 具体目标是 本研究旨在开发快速、客观的角膜光学测量方法， 质量，能够预测任何学生的视觉表现变化 兴趣的大小。 这将通过计算 角膜的单色波像差 对正常眼和患有各种疾病的患者的角膜地形图测量 破坏正常角膜地形图的角膜病症。 这些数据 将反过来被用来量化的数量和程度的变化， 高阶像差及其对光学传递的影响 正常眼和受损眼的角膜功能（OTF） 角膜地形图;并预测眼睛视觉的变化 性能作为瞳孔大小的函数。 研究的最终目标 是确定改变的角膜地形图和 视觉功能减弱，从而减轻 角膜治疗旨在改善眼睛的图像质量。

DESCRIPTION: (Adapted from applicant's abstract.) The evaluation of optical quality of the normal and abnormal cornea has been limited principally to measurements of visual performance such as contrast sensitivity, acuity and glare. While these measures reflect aspects of corneal optical quality, they do not readily reflect changes in optical performance as a function of pupil size, nor give insight to the specific cause of the various optical improvements or deficits. The specific aim of this research is to develop fast, objective measures of corneal optical quality, capable of predicting changes in visual performance for any pupil size of interest. This will be accomplished by calculating the monochromatic wave aberrations of the cornea from the state-of-the-art corneal topography measurements on normal eyes and patients having various corneal conditions which disrupt normal corneal topography. These data will in turn be used to quantify the amount and degree of variation in the higher order aberrations and their influence on the optical transfer function (OTF) of the cornea for normal eyes and eyes with disrupted corneal topography; and predict the resulting changes in the eye's visual performance as a function of pupil size. The ultimate goal of the research is to identify the relationship between altered corneal topography and diminished visual function, thus lessening the adverse consequences of corneal therapies designed to improve the image quality of the eye.