FIBER OPTIC RAMAN IMAGER FOR VISUALIZING DENTAL CARIES

用于可视化龋齿的光纤拉曼成像仪

• 批准号: 9442785
• 负责人: Shan Yang
• 金额: $ 13.32万
• 依托单位: JACKSON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-03-01 至 2020-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9442785
• 关键词: Acids; Area; Benchmarking; Clinical; Collection; Complex; Computer software; Custom; Data; Dental; Dental Care; Dental Clinics; Dental Enamel; Dental Implants; Dental caries; Dental crowns; Dentin; Detection; Devices; Diagnosis; Diagnostic; Diagnostic Sensitivity; Disease Progression; Early Diagnosis; Feasibility Studies; Fiber Optics; Gold; Hand; Head; Histology; Image; Imaging Device; Individual; Intervention; Lasers; Lesion; Life; Light; Location; Measurable; Microscope; Minerals; Modality; Optics; Oral; Oral cavity; Oral health; Outcome; Patients; Penetration; Performance; Photons; Pilot Projects; Population; Positioning Attribute; Process; Roentgen Rays; Sampling; Scanning; Sensitivity and Specificity; Severities; Signal Transduction; Speed; Spottings; Surveys; System; Tactile; Technology; Testing; Time; Tooth Loss; Tooth structure; Treatment Cost; Visual; White Spots; base; care costs; clinical application; commercialization; cost; demineralization; early onset; imager; imaging study; imaging system; improved; in vivo; innovation; lens; mineralization; new technology; portability; remineralization; repaired; screening; sound; success; tool; tooth surface

Summary Dental caries is the most significant problem in oral health area. Early detection of caries is highly desired because decays can be reversed by remineralization. When detected later, caries result in costly treatments such as fillings, bridge, crown or dental implants, amounting to thousands of dollars per tooth. Therefore, the reliable diagnosis of decay at the early onset would have a significant impact by curbing the progression of the disease before the advanced stage of tooth decay and, in turn, alleviate the associated dental-care costs. Because early onset lesions are elusive to current technologies, there is great emphasis on developing new technologies for early diagnosis of caries. Raman imaging is promising but it needs to be lower cost and customized for the dental operatory. Raman can detect caries by visualizing changes in the mineralization of decaying enamel. The speed of existing Raman modalities (point by point scan etc.) does not allow a systematic survey of the oral space, and the Raman microscopes are too bulky and complex to be used in the dental operatory. A fiber optic Raman- imaging tool is essential to enable clinical utilization of Raman. The major aim of the proposed pilot study is to develop a Raman imaging device for early detection of caries. Aim 1 will integrate a hand- held fiber optic Raman imager for dental diagnostics. This imager is a portable and automated platform that is an innovative combination of microarray based wide-field excitation and 2D- signal collection optics to generate mineralization distributions of the occlusal, frontal and posterior aspects of the teeth. The system will generate full-field images of teeth surface finding lesions as least 100 µm size in the oral space within 5 minutes. Aim 2 will validate and refine the performance of the imager towards the detection of caries. The limits of detection (size of the lesion and the degree of mineralization) of the system will be assessed and improved by artificially induced lesions of controlled size and severity. The imager will then be tested blindly on sound teeth samples and those with naturally occurring caries lesions to determine its sensitivity and specificity against the gold standard undemineralized histology.

总结 龋病是口腔卫生领域最重要的问题。高度期望龋齿的早期检测 因为衰变可以被矿化逆转。当以后发现时，龋齿导致昂贵的治疗， 作为填充物、牙桥、牙冠或牙科植入物，每颗牙齿价值数千美元。因此，可靠的 在早期发病时诊断出衰变将通过抑制疾病的进展而产生重大影响 在蛀牙的晚期之前，反过来，减轻相关的牙科护理费用。因为早期 发病病变是难以捉摸的，目前的技术，有很大的重点是发展新的技术，为早期 龋齿的诊断拉曼成像是有前途的，但它需要更低的成本和定制的牙科 手术的拉曼可以通过观察腐烂牙釉质的矿化变化来检测龋齿。速度 现有的拉曼模态（逐点扫描等）不允许对口腔空间进行系统的调查， 拉曼显微镜过于庞大和复杂，不能用于牙科手术室。光纤拉曼- 成像工具对于拉曼的临床应用是必不可少的。拟议试点研究的主要目标 目的是研制一种用于早期检测龋齿的拉曼成像装置。目标1将整合一只手- 用于牙科诊断手持光纤拉曼成像仪。这款成像仪是一款便携式自动化平台 这是基于宽场激发和2D信号收集光学器件微阵列的创新组合， 生成牙齿的咬合面、正面和背面的矿化分布。系统将 生成牙齿表面的全视野图像，在5分钟内发现口腔空间中至少100 µm大小的病变。 目标2将验证和完善成像仪检测龋齿的性能。的 将评估系统的检测限（病变大小和矿化程度）， 通过控制大小和严重程度的人工诱导病变来改善。然后，成像器将在以下条件下进行盲测： 健康的牙齿样本和那些自然发生龋齿病变，以确定其敏感性和特异性 与黄金标准的未矿化组织学相比。