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Summary Dental caries is the most significant problem in oral health area. Early detection of caries is highly desired because decays can be reversed by remineralization. When detected later, caries result in costly treatments such as fillings, bridge, crown or dental implants, amounting to thousands of dollars per tooth. Therefore, the reliable diagnosis of decay at the early onset would have a significant impact by curbing the progression of the disease before the advanced stage of tooth decay and, in turn, alleviate the associated dental-care costs. Because early onset lesions are elusive to current technologies, there is great emphasis on developing new technologies for early diagnosis of caries. Raman imaging is promising but it needs to be lower cost and customized for the dental operatory. Raman can detect caries by visualizing changes in the mineralization of decaying enamel. The speed of existing Raman modalities (point by point scan etc.) does not allow a systematic survey of the oral space, and the Raman microscopes are too bulky and complex to be used in the dental operatory. A fiber optic Raman- imaging tool is essential to enable clinical utilization of Raman. The major aim of the proposed pilot study is to develop a Raman imaging device for early detection of caries. Aim 1 will integrate a hand- held fiber optic Raman imager for dental diagnostics. This imager is a portable and automated platform that is an innovative combination of microarray based wide-field excitation and 2D- signal collection optics to generate mineralization distributions of the occlusal, frontal and posterior aspects of the teeth. The system will generate full-field images of teeth surface finding lesions as least 100 µm size in the oral space within 5 minutes. Aim 2 will validate and refine the performance of the imager towards the detection of caries. The limits of detection (size of the lesion and the degree of mineralization) of the system will be assessed and improved by artificially induced lesions of controlled size and severity. The imager will then be tested blindly on sound teeth samples and those with naturally occurring caries lesions to determine its sensitivity and specificity against the gold standard undemineralized histology.
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Role of Water in Dental Hard Tissues
  • 批准号:
    10333042
  • 项目类别:
  • 资助金额:
    $9.74万
  • 财政年份:
    2022
  • 负责人:
    Shan Yang
  • 依托单位:
Role of Water in Dental Hard Tissues
  • 批准号:
    10609409
  • 项目类别:
  • 资助金额:
    $10.98万
  • 财政年份:
    2022
  • 负责人:
    Shan Yang
  • 依托单位:
国内基金
海外基金
层出镰刀菌氮代谢调控因子AreA 介导伏马菌素 FB1 生物合成的作用机理
  • 批准号:
    2021JJ40433
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2021
  • 负责人:
    孙磊
  • 依托单位:
寄主诱导梢腐病菌AreA和CYP51基因沉默增强甘蔗抗病性机制解析
  • 批准号:
    32001603
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    24.0万元
  • 批准年份:
    2020
  • 负责人:
    段真珍
  • 依托单位:
AREA国际经济模型的移植.改进和应用
  • 批准号:
    18870435
  • 项目类别:
    面上项目
  • 资助金额:
    2.0万元
  • 批准年份:
    1988
  • 负责人:
    史树中
  • 依托单位: