Fast Methods for Mapping Focused Ultrasound Pressure Fields

绘制聚焦超声压力场的快速方法

• 批准号: 9388181
• 负责人: William A Grissom
• 金额: $ 23.57万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9388181
• 关键词: 3D ultrasound; Acoustics; Address; Adopted; Benchmarking; Blood - brain barrier anatomy; Clinic; Clinical; Communication; Computer software; Cone; Development; Devices; Dictionary; Dimensions; Drug Delivery Systems; Equation; Equilibrium; Experimental Designs; Fibroid Tumor; Focused Ultrasound; Focused Ultrasound Therapy; Geometry; Goals; Gold; Hour; Image; Imaging Device; In Situ; Lasers; Light; Liquid substance; Location; Magnetic Resonance Imaging; Maps; Measurement; Measures; Methods; Modality; Modeling; Morphologic artifacts; Motion; Needles; Optical Methods; Optics; Pattern; Privatization; Process; Protocols documentation; Radiation; Recording of previous events; Refractive Indices; Research; Resolution; Safety; Sampling; Scanning; Shapes; Ships; Speed; System; Tablets; Techniques; Technology; Therapeutic; Time; Transducers; Translating; Ultrasonic Transducer; Ultrasonography; Validation; Visible Radiation; Water; Work; base; brain surgery; cost; density; design; dosimetry; flexibility; imaging system; innovation; instrument; mathematical model; mathematical theory; portability; pre-clinical; pressure; quality assurance; reconstruction; research and development; simulation; spatiotemporal; theories; tomography; tool; treatment planning; tumor

Project Summary The goal of this R21 EBRG project is to develop new optical methods to map high intensity focused ultrasound (HIFU) pressure fields. The methods would enable simple, fast, and low-cost in situ HIFU beam measurements, which are needed for quality assurance and safety in the clinic, and to accelerate the pace of research and development of new HIFU applications and technologies. An ideal beam mapping instrument would be low cost, capable of rapidly measuring relevant acoustic parameters of clinical HIFU systems in situ between treatments, and usable by nontechnical experts. Needle hydrophones are currently the gold standard tool for mapping HIFU pressure fields, but are poorly suited to the measurement task since they sample only one spatial location at a time, and most can only measure sub- therapeutic pressures. They can be translated in a water tank by a motion stage to produce spatially-resolved pressure maps, but this is a slow and cumbersome measurement that can take several hours to complete. The techniques proposed in this application could meet this clinical need and also provide a fast, flexible, and spatially- resolved beam mapping instrument that would be invaluable for HIFU research since it would enable rapid val- idation and experimental designs that are currently infeasible, such as mapping pressure fields across multiple experimental variables. Standard optical schlieren imaging has a long history in 2D and 3D ultrasound pressure field mapping but has conventionally been applied using sophisticated and expensive high-speed optical setups with limited field-of-view, limited portability and high cost. The methods and devices proposed in this project are instead based on a newer schlieren technique called background oriented schlieren (BOS) imaging, and in their simplest form can be implemented using just a water tank, a tablet PC and a webcam. In essence, BOS trades the sophisticated optical setup for more sophisticated computation, which is a much cheaper commodity. The central innovation in this project is to use BOS imaging to quantitatively map continuous-wave HIFU pressure fields in 2D and 3D. The first Aim is to develop portable hardware for BOS imaging and tomography, that can be used with a wide variety of HIFU systems in situ. The second Aim is to develop the mathematical theory underlying the BOS image formation process for HIFU beam mapping, which is different from conventional BOS imaging since the underlying refractive index field is not static. The third Aim is to develop acquisition and reconstruction methods that produce quantitative spatially-resolved pressure field maps, and validate those maps against simulations and optical hydrophone measurements of state-of-the-art HIFU systems. By developing and disseminating BOS hardware, theory, and methods for quantitative 2D and 3D HIFU beam mapping, this development project will lead to fast, simple and robust devices that can be widely adopted and even shipped with each clinical HIFU system for regular quality assurance and exposimetry measurements.

项目摘要 这个R21 EBRG项目的目标是开发新的光学方法来映射高强度聚焦超声 （HIFU）压力场。该方法将能够实现简单、快速和低成本的原位HIFU束测量， 这是临床质量保证和安全所需的，并加快了研究和 开发新的HIFU应用和技术。 理想的波束成像仪器应是低成本的，能够快速测量相关的声学参数， 治疗之间的临床HIFU系统原位参数，可由非技术专家使用。针 水听器目前是标测HIFU压力场的黄金标准工具，但不适合 测量任务，因为他们一次只采样一个空间位置，而且大多数只能测量亚空间位置。 治疗压力它们可以通过运动台在水箱中平移以产生空间分辨的 压力图，但这是一个缓慢而繁琐的测量，可能需要几个小时才能完成。的 本申请中提出的技术可以满足这种临床需要，并且还提供快速、灵活和空间上- 解决光束映射仪器，这将是非常宝贵的HIFU研究，因为它将使快速瓦尔- 目前不可行的验证和实验设计，例如在多个区域映射压力场 实验变量标准光学纹影成像在2D和3D超声压力方面具有悠久的历史 场映射，但是传统上使用复杂且昂贵的高速光学设置来应用 具有有限的视场、有限的便携性和高成本。本项目提出的方法和装置是 而是基于称为背景定向纹影（BOS）成像的较新的纹影技术，并且在其 最简单的形式可以使用水箱，平板电脑和网络摄像头来实现。本质上，BOS交易 复杂的光学装置用于更复杂的计算，这是一种便宜得多的商品。 该项目的核心创新是使用BOS成像来定量映射连续波HIFU 二维和三维的压力场。第一个目标是开发用于BOS成像和断层扫描的便携式硬件， 其可以与多种HIFU系统原位使用。第二个目标是发展数学 HIFU束映射的BOS成像过程的理论基础，这不同于传统的 BOS成像，因为底层折射率场不是静态的。第三个目标是发展收购 和重建方法，产生定量的空间分辨压力场图，并验证这些 与最先进的HIFU系统的模拟和光学水听器测量进行映射。发展中 和传播BOS硬件，理论和定量2D和3D HIFU束映射的方法， 开发项目将导致快速，简单和强大的设备，可以广泛采用，甚至装运 与每个临床HIFU系统一起进行定期质量保证和曝光测量。