Interdisciplinary Translational Pre/Postdoctoral Program in Cancer Nanotechnology

癌症纳米技术跨学科转化博士前/博士后项目

• 批准号: 9325470
• 负责人: Sunil Krishnan
• 金额: $ 47.61万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9325470
• 关键词: Malignant Neoplasms; Nanotechnology; programs

 DESCRIPTION (provided by applicant): In the last decade there has been an exponential growth in nanotechnology research in cancer demonstrating that nanotechnology could provide unique and otherwise unattainable solutions to cancer management including very early cancer detection, accurate molecular specific diagnosis and treatment that diminishes side effects. However, achieving this promise is extremely challenging because it requires overcoming multiple constraints imposed by translational barriers in clinical applications of nanomaterials that is multiplied by complexity of cancer biology. Currently, there is a growing gap between new discoveries coming at a fast pace from academic labs and their translation into clinic. Therefore, there is an urgent need in addressing this gap in cancer nanotechnology translational pipeline. To this end, we have designed a novel training program to educate future leaders in the broad field of nanotechnology with specific interests in cancer-related applications, who are keenly aware of the needs and demands of clinical environment as well as of major challenges of translational research. We believe that the only way to train cancer translation minded Ph.D. researchers is to insert them into the environment of an outstanding cancer center. Therefore, our program is based on a close collaboration between The University of Texas MD Anderson Cancer Center and Rice University. As part of our program, we have developed a comprehensive plan for recruiting trainees from underrepresented minority groups that are historically underrepresented in health-related research, including women, minority individuals, and individuals with disabilities. Our training program includes multidisciplinary mentorship of translational research projects combined with multidisciplinary, hands-on coursework and seminar experiences. All trainees will work with at least two program faculty mentors (one from Rice and one from MD Anderson) to define and carry out an independent research problem. Didactic coursework will prepare them to contribute to research projects that directly address barriers to translation of nanotechnology-based approaches and to develop the skills needed to define and lead such projects. Incoming trainees will participate in a unique 2-week-long boot camp in "Cancer Management and Nanotechnology" that provides an overview of current opportunities and barriers in the field. Trainees will develop foundational background in the field by taking four courses related to translational cancer or nanotechnology topics. Trainees will gain an appreciation for federal resources to assist in cancer nanotechnology research by taking a trip to the NCI Nanotechnology Characterization Lab. Finally, trainees will gain important lab management skills by participating in a short hands-on course providing an introduction to laboratory and project management. At the end of the program, fellows will have a deep understanding of translational research in cancer nanotechnology, with the most important component being the demonstrated ability to carry out independent translational research in this challenging multidisciplinary field.

 描述(申请人提供)：在过去的十年中，纳米技术在癌症方面的研究呈指数级增长，表明纳米技术可以为癌症管理提供独特的、否则无法实现的解决方案，包括非常早期的癌症检测、准确的分子特异性诊断和减少副作用的治疗。然而，实现这一承诺是极其具有挑战性的，因为它需要克服纳米材料临床应用中翻译障碍施加的多重限制，而翻译障碍又增加了癌症生物学的复杂性。目前，来自学术实验室的快速新发现与转化为临床的新发现之间的差距越来越大。因此，迫切需要解决癌症纳米技术转化管道中的这一缺口。为此，我们设计了一项新颖的培训计划，以培养未来纳米技术领域的领导者，他们对癌症相关应用具有特定的兴趣，他们敏锐地意识到临床环境的需求和要求，以及翻译研究的主要挑战。我们认为，培养具有癌症翻译思维的博士研究人员的唯一方法是将他们插入到一个杰出的癌症中心的环境中。因此，我们的项目是基于德克萨斯大学MD安德森癌症中心和莱斯大学的密切合作。作为我们计划的一部分，我们制定了一项全面的计划，从代表不足的少数群体中招募受训人员，这些群体在与健康相关的研究中历来代表不足，包括妇女、少数族裔个人和残疾个人。我们的培训计划包括对翻译研究项目的多学科指导，结合多学科、实践课程和研讨会经验。所有受训人员将与至少两名项目教师导师(一名来自莱斯，一名来自MD Anderson)合作，以定义和开展独立研究问题。授课课程将使他们做好准备，为直接解决纳米技术方法翻译障碍的研究项目做出贡献，并发展定义和领导此类项目所需的技能。即将到来的学员将参加一个为期两周的独特的“癌症管理和纳米技术”新兵训练营，该训练营概述了该领域当前的机会和障碍。学员将发展该领域的基础背景 通过参加四门与转化性癌症或纳米技术相关的课程。学员将通过参观NCI纳米技术表征实验室获得联邦资源来协助癌症纳米技术研究。最后，学员将通过参加一个介绍实验室和项目管理的短期实践课程，获得重要的实验室管理技能。在项目结束时，研究人员将对癌症纳米技术中的翻译研究有深入的了解，其中最重要的组成部分是证明有能力在这个具有挑战性的多学科领域开展独立的翻译研究。