Bridging the Gap to Enhance Clinical Research Program (BIGGER)

弥合差距，加强临床研究计划（BIGGER）

• 批准号: 9228683
• 负责人: VIVIAN H CHU
• 金额: $ 9.74万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-15 至 2021-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9228683
• 关键词: Acceleration; Address; Affect; African American; Area; Arts; Attention; Cardiac; Cardiovascular Diseases; Cardiovascular system; Caring; Cause of Death; Child; Clinical; Clinical Research; Communication; Complement; Databases; Drug Kinetics; Education; Educational Curriculum; Educational workshop; Effectiveness; Enrollment; Ensure; Environment; Faculty; Fostering; Funding; Future; Genetic Markers; Goals; Grant; Health; Health Professional; Health Sciences; Heart Diseases; Heart failure; High School Student; Implantable Defibrillators; Individual; Infective endocarditis; Interview; Investigation; Leadership; Learning; Medical; Medical Students; Mentors; Mentorship; Methods; North Carolina; Online Systems; Participant; Pharmaceutical Preparations; Population Heterogeneity; Positioning Attribute; Prevention; Principal Investigator; Public Health; Recruitment Activity; Research; Research Ethics; Research Infrastructure; Research Institute; Research Methodology; Resources; Review Literature; Running; Schools; Science; Scientist; Solid; Structure; Students; Training; Training Programs; Training Support; Underrepresented Minority; Underrepresented Students; United States; United States National Institutes of Health; Universities; Vulnerable Populations; Work; Writing; base; cardiovascular risk factor; career; career development; college; congenital heart disorder; curriculum development; ethnic diversity; experience; faculty mentor; hands on research; health disparity; high school; improved; knowledge base; medical schools; member; method development; mid-career faculty; older patient; programs; public health relevance; racial disparity; racial diversity; research and development; skills; success; summer research; symposium; tool development; undergraduate student

Project Summary/Abstract The BrIdGing the Gap to Enhance Clinical Research Program (referred to henceforth as the “BIGGER” program) will provide a high-quality research experience for students in their gap year, defined as the period after college graduation and prior to enrollment in graduate/professional school. The program will comprise a partnership between Duke University, the University of North Carolina, and North Carolina Central University (the nation’s first liberal arts college founded for African Americans) to enhance the diversity of the clinical research workforce, thereby ensuring that health concerns of underrepresented minorities remain a part of the national research agenda. Students will be exposed to a hands-on research experience that will encourage future research careers, and they will obtain career development tools to foster professional success. The program will expand and complement NIH-sponsored training resources already in place at Duke University under the leadership of the principal investigators, Dr. Kevin Thomas and Dr. Vivian Chu. This leadership structure synergistically combines scientific expertise and connections in cardiovascular disease (Dr. Thomas) with clinical research and career development curriculum expertise (Dr. Chu). In addition, the Duke Clinical Research Institute (DCRI) offers formal educational and support programs for junior faculty, fellows, residents, medical students, undergraduates, and high school students, with funding from internal DCRI resources as well as the NIH. The proposed program represents a unique piece in a continuum of NIH-supported training at the DCRI that runs the gamut from the high school-level to mid-career faculty. While the proportion of gap-year students is increasing, there are limited opportunities for these students to engage in a meaningful, career development experience. This program will be ideally positioned to fill this need using an established educational infrastructure with a track record of successful trainees. The program will take place over 6 months. Each participant will be paired with a senior Duke faculty mentor and will be integrated into the work of the mentor’s team for a collaborative research experience. Participants will work on an individual scholarly project, which will be original and hypothesis-driven. For the first 3 weeks of the program, trainees will work with their faculty mentors to develop a solid knowledge base of a specific clinical question based on a thorough review of the literature. During weeks 4-22, the trainees will develop a 6- page thesis consisting of a description of the research question, specific aims, methods, and figures/tables for the study. Throughout the program, didactics will focus on clinical research methods, research ethics, and writing skills and will be taught by Duke faculty and a dedicated medical writer. Trainees will work with their mentors throughout the course of the program to review their progress and the scientific validity of their work. At the conclusion of the program, trainees will present the results of their work to the faculty and staff at the DCRI. Finally, trainees will be followed for 10 years using a web-based database to assess the effectiveness of the training program. The proposed program will result in an improved, more diverse pipeline of future scientists whose practical experience in clinical research will facilitate their entry into research careers.

项目总结/摘要 弥合差距加强临床研究项目（以下简称“BIGGER”） 计划）将为学生提供高质量的研究经验，在他们的差距年，定义为期间 大学毕业后和研究生/专业学校入学前。该计划将包括一个 杜克大学、北卡罗来纳州大学和北卡罗来纳州中央大学之间的合作关系 (the美国第一所为非洲裔美国人建立的文科学院），以提高临床医学的多样性。 研究队伍，从而确保代表性不足的少数群体的健康问题仍然是研究的一部分， 国家研究议程。学生将接触到一个动手的研究经验，将鼓励 未来的研究职业，他们将获得职业发展工具，以促进专业成功。的 该计划将扩大和补充美国国立卫生研究院赞助的杜克大学已有的培训资源 在主要研究者Kevin托马斯博士和Vivian Chu博士的领导下。这种领导 在心血管疾病中，结构协同地结合了科学专门知识和联系（托马斯博士） 临床研究和职业发展课程的专业知识（朱博士）。此外，杜克临床 研究所（DCRI）为初级教师，研究员，居民， 医学生、本科生和高中生，由DCRI内部资源提供资金， 以及NIH。拟议的计划是一个独特的一块在一个连续的NIH支持的培训， DCRI涵盖了从高中到职业中期的所有教师。而间隔年的比例 学生越来越多，但这些学生从事有意义的职业的机会有限， 发展经验。该计划将是理想的定位，以填补这一需要使用一个既定的 教育基础设施，有成功受训者的记录。 该计划将持续6个月。每位参与者将与一位资深杜克教师导师配对 并将融入导师团队的工作中，以获得合作研究的经验。参与者 将致力于一个个人的学术项目，这将是原创和假设驱动。在最初的3周里， 在该计划中，学员将与他们的教师导师一起工作，以发展一个具体的坚实的知识基础。 基于对文献的全面回顾的临床问题。在第4-22周，学员将制定一个6- 一页论文，包括研究问题的描述，具体目标，方法和图表/表格， 书房在整个计划中，教学法将侧重于临床研究方法，研究伦理， 写作技巧，并将由杜克教师和一个专门的医学作家教。学员将与他们的 导师在整个计划的过程中，以审查他们的进展和他们的工作的科学有效性。 在该计划结束时，学员将向教师和工作人员介绍他们的工作成果， DCRI。最后，将使用一个基于网络的数据库对受训人员进行为期10年的跟踪，以评估 培训计划。拟议的计划将导致一个更好的，更多样化的未来管道 临床研究的实际经验将有助于他们进入研究生涯的科学家。