2016 Mutagenesis Gordon Research Conference and Gordon Research Seminar

2016年诱变戈登研究会议暨戈登研究研讨会

• 批准号: 9122639
• 负责人: Karlene A Cimprich
• 金额: $ 1.1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-01 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9122639
• 关键词: Academia; Address; Age; Aging; Animal Model; Antibody Affinity; Antigens; Area; Automobile Driving; Base Pairing; Biochemistry; Bioinformatics; Biological; Biological Models; Biology of Aging; Cellular biology; Chemicals; Childhood; Collaborations; Complex; DNA; DNA Damage; DNA Modification Process; DNA Repair; DNA Sequence; DNA biosynthesis; DNA damage checkpoint; Development; Discipline; Disease; Ensure; Epigenetic Process; Eukaryota; Evolution; Exposure to; Fertilization; Fostering; Genetic; Genetic Transcription; Genome; Genome Stability; Genomic Instability; Germ-Line Mutation; Government; Health; Hong Kong; Human; Immune system; Immunoglobulin Genes; Immunology; Inherited; Knowledge; Laboratories; Lead; Maintenance; Malignant Neoplasms; Metabolic; Molecular; Mutagenesis; Mutation; Nerve Degeneration; Outcome; Participant; Play; Postdoctoral Fellow; Process; Radiation; Rare Diseases; Recording of previous events; Research; Research Institute; Research Personnel; Role; Schedule; Scientist; Signal Transduction; Staging; Stress; Structure; Students; Study models; System; Therapeutic; Time; Toxicogenetics; Work; abstracting; age related; cancer cell; carcinogenesis; career; disorder risk; frontier; gene function; genome analysis; genome integrity; genome sequencing; human disease; insight; interest; meetings; nervous system disorder; novel; novel strategies; novel therapeutic intervention; posters; programs; public health relevance; repaired; structural biology; symposium; tool; whole genome

 DESCRIPTION (provided by applicant): The 2016 Gordon Research Conference on Mutagenesis will focus on conserved molecular mechanisms of mutagenesis, and how these mechanisms contribute to human diseases such as ageing and cancer. Mutations are changes in DNA sequence, which range from single base pair alterations to complex genome rearrangements, which are hallmarks of cancer cells. Metabolic and environmental stresses are major contributors to mutagenesis and leads to the increased risk of disease, including accelerated aging and age- related diseases such as cancer and neurodegeneration. Moreover, germ line mutations confer inherited diseases including a wide range of rare diseases and childhood disorders. Conversely, mutagenesis also plays a positive biological role in driving diversity and promoting speciation. Mutagenic mechanisms are also essential for the development of the human immune system, in which the evolution of high-affinity antibodies following exposure to a new antigen depends on the targeted mutation of immunoglobulin genes. The GRC will highlight new work encompassing a broad range of approaches, from mechanistic studies of mutagenesis, to the recent revolution in whole-genome analysis, to new therapeutic approaches. The 37 confirmed speakers and discussion leaders cover all the topics above, and these participants represent laboratories in academia, government, and research institutes. An additional 8 speakers will be selected from the submitted abstracts, and these talks will be interspersed in the schedule to ensure that the latest developments are included, and that new investigators are optimally represented on Program. The schedule is organized into an opening keynote session followed by daily morning and afternoon sessions entitled (1) Genome instability driven by transcription/replication collisions; (2) Replication stress, ageing and cancer; (3) DNA repair and mutagenesis; (4) Error-prone DNA replication and repair; (5) Ageing and cancer-associated DNA repair processes; (6) Complex genome alterations; (7) DNA secondary structures and repair; and (8) Mutational signatures in ageing and cancer. The schedule also provides ample time for vibrant group discussions and daily poster sessions will enable the presentation of work in progress and facilitate key interactions among students, postdoctoral fellows, new investigators, and more senior figures in the field. Key objectives are to explore current knowledge at the frontier of mutagenesis research, with emphasis on molecular mechanisms and novel approaches to studying these mechanisms; to define therapeutic strategies to enhance the maintenance of genomic integrity and to take advantage of mutagenesis in the treatment of disease; to stimulate novel collaborations, especially exploiting work across different experimental systems and disciplines; and to enhance and promote the careers of young scientists and encourage their continuation in the field. The venue has cutting-edge meeting facilities and breakout spaces, which will enhance scientific interactions, provide full access and support to the conference, and are a significant attraction for potential attendees.

 描述（申请人提供）：2016年戈登突变研究会议将重点关注保守的突变分子机制，以及这些机制如何导致衰老和癌症等人类疾病。突变是DNA序列的变化，其范围从单碱基对改变到复杂的基因组重排，这是癌细胞的标志。代谢和环境压力是诱变的主要因素，并导致疾病风险增加，包括加速衰老和年龄相关疾病，如癌症和神经变性。此外，种系突变赋予遗传性疾病，包括广泛的罕见疾病和儿童疾病。相反，诱变在推动多样性和促进物种形成方面也发挥着积极的生物学作用。致突变机制对于人类免疫系统的发育也是必不可少的，其中暴露于新抗原后高亲和力抗体的进化取决于免疫球蛋白基因的靶向突变。GRC将突出新的工作，包括广泛的方法，从诱变的机理研究，到最近的全基因组分析革命，再到新的治疗方法。37位已确认的演讲者和讨论负责人涵盖了上述所有主题，这些参与者代表了学术界，政府和研究机构的实验室。将从提交的摘要中选出另外8位演讲者，这些演讲将穿插在时间表中，以确保包括最新的发展，并确保新的研究人员在计划中得到最佳代表。日程安排为开幕主旨会议，随后是每天上午和下午的会议，题目是：（1）转录/复制碰撞驱动的基因组不稳定性;（2）复制压力、衰老和癌症;（3）DNA修复和诱变;（4）易出错的DNA复制和修复;（5）衰老和与癌症有关的DNA修复过程;（6）复杂的基因组改变;（7）DNA二级结构和修复;（8）衰老和癌症中的突变特征。该时间表还为充满活力的小组讨论提供了充足的时间，每天的海报会议将使正在进行的工作得以展示，并促进学生，博士后研究员，新研究人员和该领域更高级人物之间的关键互动。主要目标是探索诱变研究前沿的现有知识，重点是分子机制和研究这些机制的新方法;确定治疗策略，以加强基因组完整性的维护，并利用诱变治疗疾病;促进新的合作，特别是利用不同实验系统和学科的工作;并加强和促进青年科学家的职业生涯，鼓励他们继续在该领域工作。该场地拥有先进的会议设施和分组讨论空间，这将加强科学互动，为会议提供全面的访问和支持，并对潜在的与会者具有重要的吸引力。